Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems

Effect of abiotic elicitation and pathway precursors feeding over terpenoid indole alkaloids production in multiple shoot and callus cultures of Catharanthus roseus

(2019) Abhishek Sharma et al.   BIOLOGIA

GATA and PIF transcription factors regulate light-induced vindoline biosynthesis in Catharanthus roseus

(2019) Yongliang Liu et al.   PLANT PHYSIOLOGY

EASI Transformation: An Efficient Transient Expression Method for Analyzing Gene Function in Catharanthus roseus Seedlings

(2019) Samuel Mortensen et al.   Frontiers in Plant Science

An engineered combinatorial module of transcription factors boosts production of monoterpenoid indole alkaloids in Catharanthus roseus

(2018) Fabian Schweizer et al.   METABOLIC ENGINEERING

Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol

(2018) Mohd Zuwairi Saiman et al.   PLANT CELL TISSUE AND ORGAN CULTURE

A BAHD acyltransferase catalyzing 19-O -acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids

(2018) Inês Carqueijeiro et al.   PLANT JOURNAL

Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus

(2018) Abhishek Sharma et al.   PROTOPLASMA

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

(2018) Sarma R. Kumar et al.   Frontiers in Plant Science

Optimization of a Bacopa monnieri-based genetic transformation model for testing the expression efficiency of pathway gene constructs of medicinal crops

(2017) Abhishek Sharma et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Genetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of Catharanthus roseus

(2017) Abhishek Sharma et al.   PROTOPLASMA

Discovery and metabolic engineering of iridoid/secoiridoid and monoterpenoid indole alkaloid biosynthesis

(2016) Antje M. K. Thamm et al.   PHYTOCHEMISTRY REVIEWS

The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus

(2016) Alex Van Moerkercke et al.   PLANT JOURNAL

Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2

(2016) Liu Dong Hui et al.   AFRICAN JOURNAL OF BIOTECHNOLOGY

Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism

(2015) Anna Stavrinides et al.   CHEMISTRY & BIOLOGY

Transgenic studies for modulating terpenoid indole alkaloids pathway in Catharanthus roseus: present status and future options

(2015) Priyanka Verma et al.   PHYTOCHEMISTRY REVIEWS

Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites

(2015) Qifang Pan et al.   PHYTOCHEMISTRY REVIEWS

Genome-guided investigation of plant natural product biosynthesis

(2015) Franziska Kellner et al.   PLANT JOURNAL

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

(2015) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering overexpression of ORCA3 and strictosidine glucosidase in Catharanthus roseus hairy roots increases alkaloid production

(2015) Jiayi Sun et al.   PROTOPLASMA

Metabolic engineering approaches for production of biochemicals in food and medicinal plants

(2014) Sarah A. Wilson et al.   CURRENT OPINION IN BIOTECHNOLOGY

A look inside an alkaloid multisite plant: the Catharanthus logistics

(2014) Vincent Courdavault et al.   CURRENT OPINION IN PLANT BIOLOGY

Morphogenetic and chemical stability of long-term maintainedAgrobacterium-mediated transgenicCatharanthus roseusplants

(2014) Priyanka Verma et al.   NATURAL PRODUCT RESEARCH

7-Deoxyloganetic acid synthase catalyzes a key 3 step oxidation to form 7-deoxyloganetic acid in Catharanthus roseus iridoid biosynthesis

(2014) Vonny Salim et al.   PHYTOCHEMISTRY

Alkaloids as drug leads – A predictive structural and biodiversity-based analysis

(2014) Vafa Amirkia et al.   Phytochemistry Letters

Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16  hydroxylase from Bupleurum falcatum

(2014) T. Moses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over-expression of Catharanthus roseus tryptophan decarboxylase and strictosidine synthase in rol gene integrated transgenic cell suspensions of Vinca minor

(2014) Priyanka Verma et al.   PROTOPLASMA

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae

(2014) Elena Fossati et al.   Nature Communications

(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

(2014) Akira Nakagawa et al.   Scientific Reports

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway

(2013) Chun Li et al.   BMC PLANT BIOLOGY

Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides

(2013) Zhubo Dai et al.   METABOLIC ENGINEERING

A 7-Deoxyloganetic Acid Glucosyltransferase Contributes a Key Step in Secologanin Biosynthesis in Madagascar Periwinkle

(2013) K. Asada et al.   PLANT CELL

ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus

(2013) F. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants

(2012) Quan Wang et al.   BMC BIOTECHNOLOGY

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

(2012) Fernando Geu-Flores et al.   NATURE

Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus

(2011) Monika Jaggi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Agrobacterium tumefaciens-mediated transgenic plant production via direct shoot bud organogenesis from pre-plasmolyzed leaf explants of Catharanthus roseus

(2011) Priyanka Verma et al.   BIOTECHNOLOGY LETTERS

A Stereoselective Hydroxylation Step of Alkaloid Biosynthesis by a Unique Cytochrome P450 inCatharanthus roseus

(2011) Lesley-Ann Giddings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of a heterologous pathway for the production of flavonoids from glucose

(2011) Christine Nicole S. Santos et al.   METABOLIC ENGINEERING

The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

(2011) N. Suttipanta et al.   PLANT PHYSIOLOGY

Overexpression of transcriptional factor ORCA3 increases the accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots

(2011) K. X. Tang et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root culture

(2010) Mei-Liang Zhou et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots

(2010) Christie A.M. Peebles et al.   METABOLIC ENGINEERING

Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production

(2010) Cui-Ting Wang et al.   PLANT CELL REPORTS

Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

(2010) Waleerat Banyai et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Metabolic flux analysis as a tool in metabolic engineering of plants

(2008) Jörg Schwender   CURRENT OPINION IN BIOTECHNOLOGY

Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time

(2008) Christie A.M. Peebles et al.   METABOLIC ENGINEERING

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA