Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis

Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation

(2021) Rosa Direito et al.   Pharmaceutics

Immunomodulatory Effects of Dietary Polyphenols

(2021) Hira Shakoor et al.   Nutrients

Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9/NF-kB Signaling Axis

(2021) Constanze Buhrmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased Level of Tumor Necrosis Factor-Alpha (TNF-α) Leads to Downregulation of Nitrergic Neurons Following Bilateral Cavernous Nerve Injury and Modulates Penile Smooth Tone

(2021) Hotaka Matsui et al.   Journal of Sexual Medicine

Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis

(2021) Jie Huang et al.   Frontiers in Immunology

Management of Rheumatoid Arthritis: An Overview

(2021) Andrei-Flavius Radu et al.   Cells

Resveratrol counteracts IL‐1β‐mediated impairment of extracellular matrix deposition in 3D articular chondrocyte constructs

(2020) Sebastian Frischholz et al.   Journal of Tissue Engineering and Regenerative Medicine

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

(2020) Gyrid Nygaard et al.   Nature Reviews Rheumatology

Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis

(2020) Yen-Ju Lin et al.   Cells

Efficacy and mechanisms of dietary polyphenols in mitigating rheumatoid arthritis

(2020) Lindsey M. Christman et al.   Journal of Functional Foods

Could Polyphenols Help in the Control of Rheumatoid Arthritis?

(2019) Sung et al.   MOLECULES

Electrochemical strategies for gallic acid detection: Potential for application in clinical, food or environmental analyses

(2019) Mihaela Badea et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study

(2018) Hani M. Khojah et al.   CLINICAL RHEUMATOLOGY

Physical activity and Mediterranean diet based on olive tree phenolic compounds from two different geographical areas have protective effects on early osteoarthritis, muscle atrophy and hepatic steatosis

(2018) Marta Anna Szychlinska et al.   EUROPEAN JOURNAL OF NUTRITION

Antioxidant and hepatoprotective activity of cinnamaldehyde against isoniazid induced hepatotoxicity

(2018) Ramesh Kumar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis

(2018) Raveendhara R. Bannuru et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of MAPKs activation

(2018) Lin Du et al.   Journal of Functional Foods

Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes

(2018) Mohammad Y. Ansari et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Natural Products for Promoting Joint Health and Managing Osteoarthritis

(2018) Yves Henrotin et al.   Current Rheumatology Reports

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral Administration of a Chemically Modified Curcumin, TRB-N0224, Reduced Inflammatory Cytokines and Cartilage Erosion in a Rabbit ACL Transection Injury Model

(2018) Josephine R. Coury et al.   Cartilage

Resveratrol inhibits urban particulate matter-induced COX-2/PGE 2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB

(2017) Ming-Horng Tsai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anti-inflammatory effects of polyphenols in arthritis

(2017) Francesca Oliviero et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

(2017) Yulong Wei et al.   Molecular Medicine Reports

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti-Inflammatory M2 State

(2017) Laura Dugo et al.   Oxidative Medicine and Cellular Longevity

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes

(2017) Nazir M. Khan et al.   Scientific Reports

Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

(2016) Erin E. Mulvihill et al.   Annual Review of Nutrition

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms

(2016) Silvia Cetrullo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Greater flavonoid intake is associated with improved CVD risk factors in US adults

(2016) Kijoon Kim et al.   BRITISH JOURNAL OF NUTRITION

Inhibitory effects of alternaramide on inflammatory mediator expression through TLR4-MyD88-mediated inhibition of NF-кB and MAPK pathway signaling in lipopolysaccharide-stimulated RAW264.7 and BV2 cells

(2016) Wonmin Ko et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

(2016) Sunmin Park et al.   Genes and Nutrition

A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression

(2016) Qiuhong Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The role of the p53 tumor suppressor in metabolism and diabetes

(2016) Che-Pei Kung et al.   JOURNAL OF ENDOCRINOLOGY

Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes

(2016) Abdul Haseeb et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of Natural Stilbenes in the Prevention of Cancer

(2016) J. Antoni Sirerol et al.   Oxidative Medicine and Cellular Longevity

Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases

(2016) Md. Asiful Islam et al.   Oxidative Medicine and Cellular Longevity

Long-Term Effects of (–)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats

(2016) Anna Leichsenring et al.   PLoS One

Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption

(2016) Elsa Mével et al.   Scientific Reports

Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver

(2016) Ľudmila Pašková et al.   Journal of Immunology Research

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

(2016) Sunmin Park et al.   Genes and Nutrition

Autophagy and mitochondrial dysfunction in adjuvant-arthritis rats treatment with resveratrol

(2016) Junqiang Zhang et al.   Scientific Reports

Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis

(2015) Vishnu N. Badavath et al.   ARCHIV DER PHARMAZIE

Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway

(2015) So-Youn Min et al.   Journal of Inflammation-London

Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation

(2015) Yilmaz Ucuncu et al.   LIFE SCIENCES

Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig

(2015) M.-N. Horcajada et al.   OSTEOARTHRITIS AND CARTILAGE

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases

(2015) César Pacheco-Tena et al.   Journal of Immunology Research

Regulation of Dendritic Cell Function by Dietary Polyphenols

(2014) Manuela del Cornò et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis

(2014) María Ángeles Rosillo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

Chlorogenic Acid Inhibits Osteoclast Differentiation and Bone Resorption by Down-Regulation of Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Nuclear Factor of Activated T Cells c1 Expression

(2013) Sung Chul Kwak et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo

(2013) Dinorah Jean-Gilles et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Rheumatoid Factors: Clinical Applications

(2013) Francesca Ingegnoli et al.   DISEASE MARKERS

The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect

(2013) Kyoung-Su Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

(E)-3-(3,4-Dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one ameliorates the collagen-arthritis via blocking ERK/JNK and NF-κB signaling pathway

(2013) Xiuxia Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes

(2013) Burkhard Kloesch et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression

(2013) Giuseppe Musumeci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway

(2013) Jing Tian et al.   RHEUMATOLOGY INTERNATIONAL

Scientific Validation of the Medicinal Efficacy ofTinospora cordifolia

(2013) Amita Mishra et al.   TheScientificWorldJOURNAL

Bauhinia variegataLeaf Extracts Exhibit Considerable Antibacterial, Antioxidant, and Anticancer Activities

(2013) Amita Mishra et al.   Biomed Research International

MicroRNA-451 Down-Regulates Neutrophil Chemotaxis via p38 MAPK

(2013) Koichi Murata et al.   Arthritis & Rheumatology

Oxidative stress as a potential biomarker for determining disease activity in patients with Rheumatoid Arthritis

(2012) Sunanda Kundu et al.   FREE RADICAL RESEARCH

Acid bake-leach process for the treatment of enargite concentrates

(2012) M. Sadegh Safarzadeh et al.   HYDROMETALLURGY

Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways

(2012) Yunhe Fu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-Arthritic Effects of Magnolol in Human Interleukin 1β-Stimulated Fibroblast-Like Synoviocytes and in a Rat Arthritis Model

(2012) Jyh-Horng Wang et al.   PLoS One

Overview of biotherapy in rheumatoid arthritis (RA)

(2012) Tsutomu Takeuchi et al.   ARTHRITIS RESEARCH & THERAPY

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of regulatory T cells by green tea polyphenol EGCG

(2011) Carmen P. Wong et al.   IMMUNOLOGY LETTERS

Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity

(2011) Samia Z. HASSAN et al.   International Journal of Rheumatic Diseases

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

(2011) Jing Wang et al.   RHEUMATOLOGY INTERNATIONAL

Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes

(2011) Nahid Akhtar et al.   ARTHRITIS RESEARCH & THERAPY

Redox signalling and the inflammatory response in rheumatoid arthritis

(2010) L. I. Filippin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro

(2010) Mehdi Shakibaei et al.   Genes and Nutrition

Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

(2010) Gamal Ramadan et al.   INFLAMMATION

The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level

(2010) M. P. Chen et al.   INFLAMMATION RESEARCH

Fisetin Inhibits Lipopolysaccharide-Induced Macrophage Activation and Dendritic Cell Maturation

(2010) Sheng-Hung Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green Tea (Camelia Sinensis) Suppresses B Cell Production Of IgE Without Inducing Apoptosis

(2010) E. Hassanain et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biomarkers of antioxidant status following ingestion of green teas at different polyphenol concentrations and antioxidant capacity in human volunteers

(2010) Monia Pecorari et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes

(2010) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

(2010) Feng-Cheng Liu et al.   ARTHRITIS RESEARCH & THERAPY

Bioactive Food Components, Inflammatory Targets, and Cancer Prevention

(2009) Y. S. Kim et al.   Cancer Prevention Research

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis

(2009) Constanze Csaki et al.   ARTHRITIS RESEARCH & THERAPY

(−)‐Epigallocatechin‐3‐gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice

(2008) Akio Morinobu et al.   ARTHRITIS AND RHEUMATISM

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis

(2008) Erika H. Noss et al.   IMMUNOLOGICAL REVIEWS

Effects of α-Glucosylhesperidin, a Bioactive Food Material, on Collagen-Induced Arthritis in Mice and Rheumatoid Arthritis in Humans

(2008) Takashi Kometani et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Epigallocatechin-3-gallate suppresses TNF-α -induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts

(2008) Hee-Jin Yun et al.   RHEUMATOLOGY INTERNATIONAL

Epigallocatechin gallate affects human dendritic cell differentiation and maturation

(2007) Satomi Yoneyama et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY