Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Novel Synthetic Routes to Prepare Biologically Active Quinoxalines and Their Derivatives: A Synthetic Review for the Last Two Decades

(2021) Hena Khatoon et al.   MOLECULES

Isoangustone A induces autophagic cell death in colorectal cancer cells by activating AMPK signaling

(2021) Shunan Tang et al.   FITOTERAPIA

New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment

(2021) Hui-Chun Geng et al.   BIOORGANIC CHEMISTRY

Ophiopogonin B induces reactive oxygen species‑dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma

(2021) Wenhui Dong et al.   Molecular Medicine Reports

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

(2021) Pankaj Sharma et al.   MOLECULES

Biological Activity of Naturally Derived Naphthyridines

(2021) Gabriela Chabowska et al.   MOLECULES

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

(2021) Patrick O. Sakyi et al.   Natural Products and Bioprospecting

Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity

(2020) Le-le Zhang et al.   ACTA PHARMACOLOGICA SINICA

Selected Fungal Natural Products with Antimicrobial Properties

(2020) Dorota Jakubczyk et al.   MOLECULES

Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer

(2020) Xinglin Li et al.   ACS Medicinal Chemistry Letters

Uses of cyclohexane-1,3-dione for the synthesis of 1,2,4-triazine derivatives as anti-proliferative agents and tyrosine kinases inhibitors

(2020) Nadia Y. Megally Abdo et al.   BIOORGANIC CHEMISTRY

Nano-Sized MIL-100(Fe) as a Carrier Material for Nitidine Chloride Reduces Toxicity and Enhances Anticancer Effects In Vitro

(2020) JiaRui Bi et al.   Journal of Inorganic and Organometallic Polymers and Materials

Preclinical assessment of the VEGFR inhibitor axitinib as a therapeutic agent for epithelial ovarian cancer

(2020) E Sun Paik et al.   Scientific Reports

Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines

(2020) Worku Dinku et al.   Applied Biological Chemistry

Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches

(2020) Harman Saman et al.   Cancers

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells

(2020) Laxminarayan Rawat et al.   BIOMEDICINE & PHARMACOTHERAPY

Tetrazoles as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

(2020) Neha Dhiman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K+ channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones

(2020) Angel H. Romero et al.   BIOORGANIC CHEMISTRY

Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases

(2020) Perihan A. Elzahhar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytotoxicity and apoptosis‐inducing activity of novel 1 H ‐benzo[ d ]imidazole derivatives of dehydroabietic acid

(2020) A‐Liang Li et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-κB system

(2020) Binbin Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Synthesis and Evaluation of Novel Anticancer Compounds Derived from the Natural Product Brevilin A

(2020) Magnolia Muk-Lan Lee et al.   ACS Omega

Pharmacological profile of natural and synthetic compounds with rigid adamantane-based scaffolds as potential agents for the treatment of neurodegenerative diseases

(2020) Valery M. Dembitsky et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors

(2020) Kavitha Donthiboina et al.   BIOORGANIC CHEMISTRY

Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway

(2020) Jia Jia et al.   Applied Biological Chemistry

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

(2020) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents

(2020) Ashraf A. Aly et al.   MOLECULES

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

(2019) Giuseppe Ercolano et al.   Marine Drugs

Vessel co-option in cancer

(2019) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents

(2019) Jinbao Wei et al.   Frontiers in Chemistry

Potential Anticancer Properties and Mechanisms of Action of Formononetin

(2019) Dongjun Jiang et al.   Biomed Research International

Current trends and challenges in cancer management and therapy using designer nanomaterials

(2019) P. N. Navya et al.   Nano Convergence

Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents

(2019) Ling Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Effects of Fucoidan: A Review on Recent Studies

(2019) Sibusiso Luthuli et al.   Marine Drugs

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of sulphur-heterocycles in medicinal chemistry: An update

(2019) Shelly Pathania et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization

(2019) Jessica Ceramella et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Treatment with a new benzimidazole derivative bearing a pyrrolidine side chain overcomes sorafenib resistance in hepatocellular carcinoma

(2019) Fat-Moon Suk et al.   Scientific Reports

Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

(2019) Qianqian Zhang et al.   Frontiers in Pharmacology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells

(2019) Zhaoshi Bai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A

(2019) Chao Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds

(2019) Ahmed K. Farag et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

(2019) Raluca Ioana Teleanu et al.   Journal of Clinical Medicine

Emerging role of amiodarone and dronedarone, as antiarrhythmic drugs, in treatment of leishmaniasis

(2018) A. Oryan et al.   ACTA TROPICA

Recent Advances and Perspectives in Cancer Drug Design

(2018) LUMA G. MAGALHAES et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways

(2018) Yifei Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Promising Targets in Anti-cancer Drug Development: Recent Updates

(2018) Bhupinder Kumar et al.   CURRENT MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer

(2018) Andrea Bistrović et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

(2018) Yuki Yamaguchi et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal fibroblasts

(2018) Yumi Kitahiro et al.   Journal of Natural Medicines

Crambescidin 800, Isolated from the Marine Sponge Monanchora viridis, Induces Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells

(2018) Sumi Shrestha et al.   Marine Drugs

The Anti-Cancer Effects of Frondoside A

(2018) Thomas E. Adrian et al.   Marine Drugs

Regulation of Tumor Progression by Programmed Necrosis

(2018) Su Yeon Lee et al.   Oxidative Medicine and Cellular Longevity

Gefitinib or lapatinib with foretinib synergistically induce a cytotoxic effect in melanoma cell lines

(2018) Ewelina Dratkiewicz et al.   Oncotarget

Design, synthesis and pharmacological evaluation of novel 2-chloro-3-(1H-benzo[d]imidazol-2-yl)quinoline derivatives as antitumor agents: in vitro and in vivo antitumor activity, cell cycle arrest and apoptotic response

(2018) Wen-Bin Kuang et al.   RSC Advances

Current research on anti-breast cancer synthetic compounds

(2018) Jia Liu et al.   RSC Advances

Functional role of ginseng-derived compounds in cancer

(2018) Akash Ahuja et al.   Journal of Ginseng Research

Unraveling the Role of Angiogenesis in Cancer Ecosystems

(2018) Iratxe Zuazo-Gaztelu et al.   Frontiers in Oncology

Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase

(2018) Zhi-Hao Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nagilactone E suppresses TGF-β1-induced epithelial–mesenchymal transition, migration and invasion in non-small cell lung cancer cells

(2018) Le-Le Zhang et al.   PHYTOMEDICINE

Carrageenan: a review

(2018) J. Necas et al.   VETERINARNI MEDICINA

Design and synthesis of some β-carboline derivatives as multi-target anticancer agents

(2018) Mohamed A Abdelsalam et al.   Future Medicinal Chemistry

Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells

(2018) Jie Wang et al.   OncoTargets and Therapy

Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells

(2018) Aeyung Kim et al.   Frontiers in Pharmacology

Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance

(2017) Gao-Feng Zha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological activities of farnesiferol C: a review

(2017) Jamal Kasaian et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

(2017) Pankaj Sehgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Inhibitory Activity of Luzonicosides from the Starfish Echinaster luzonicus against Human Melanoma Cells

(2017) Olesya Malyarenko et al.   Marine Drugs

Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity

(2017) Dorcas Osei-Safo et al.   MOLECULES

Three new antitumor annonaceous acetogenins from the seeds of Annona squamosa

(2017) Chengyao Ma et al.   NATURAL PRODUCT RESEARCH

Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests

(2017) Florence Lefranc et al.   SEMINARS IN CANCER BIOLOGY

Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy

(2017) Shuai Ji et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Salinomycin: A new paradigm in cancer therapy

(2017) Jayant Dewangan et al.   TUMOR BIOLOGY

Imidazoles as potential anticancer agents

(2017) Imran Ali et al.   MedChemComm

Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma

(2017) Jong Cheon Joo et al.   Oncotarget

Small hybrid heteroaromatics: resourceful biological tools in cancer research

(2017) Vikrant Abbot et al.   RSC Advances

Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents

(2017) Jinfeng Wang et al.   Scientific Reports

Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer

(2017) Hsien-Yeh Hsu et al.   Scientific Reports

A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus

(2017) Atmika Paudel et al.   Frontiers in Microbiology

Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)

(2016) Salwa Mansur Ali et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis of hybrid 4-deoxypodophyllotoxin–5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest

(2016) Xiao-Wen Guan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immunomodulatory and anticancer potential of Gan cao (Glycyrrhiza uralensis Fisch.) polysaccharides by CT-26 colon carcinoma cell growth inhibition and cytokine IL-7 upregulation in vitro

(2016) Peter Amwoga Ayeka et al.   BMC Complementary and Alternative Medicine

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties

(2016) Surendra R. Punganuru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC

(2016) Fan-Wei Peng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer

(2016) Sergey A. Dyshlovoy et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model

(2016) Meyada Khaled et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer

(2016) Andrew J. Robles et al.   JOURNAL OF NATURAL PRODUCTS

Eclalbasaponin II induces autophagic and apoptotic cell death in human ovarian cancer cells

(2016) Yoon Jin Cho et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU

(2016) Yuqi Jiang et al.   Medicinal Chemistry

Effects of ophiopogonin B on the proliferation and apoptosis of SGC-7901 human gastric cancer cells

(2016) WEIYUE ZHANG et al.   Molecular Medicine Reports

Berberine enhances the anti-tumor activity of tamoxifen in drug-sensitive MCF-7 and drug-resistant MCF-7/TAM cells

(2016) Chunjie Wen et al.   Molecular Medicine Reports

The Traditional Medicine and Modern Medicine from Natural Products

(2016) Haidan Yuan et al.   MOLECULES

Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines

(2016) XIAO-MENG CHEN et al.   Oncology Letters

Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

(2016) Lianhui Sun et al.   Nature Communications

Licoricidin, an isoflavonoid isolated from Glycyrrhiza uralensis Fisher, prevents UVA-induced photoaging of human dermal fibroblasts

(2016) K. J. Kim et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α

(2015) Hye Jin Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Induction of apoptosis by genipin inhibits cell proliferation in AGS human gastric cancer cells via Egr1/p21 signaling pathway

(2015) Hyeonseok Ko et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Macrocyclic compounds as anti-cancer agents: Design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2

(2015) Cheng-Qing Ning et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum

(2015) Qin-Ying Liu et al.   Marine Drugs

Phorbaketal A, Isolated from the Marine Sponge Phorbas sp., Exerts Its Anti-Inflammatory Effects via NF-κB Inhibition and Heme Oxygenase-1 Activation in Lipopolysaccharide-Stimulated Macrophages

(2015) Yun-Ji Seo et al.   Marine Drugs

Ophiobolin O Isolated from Aspergillus ustus Induces G1 Arrest of MCF-7 Cells through Interaction with AKT/GSK3β/Cyclin D1 Signaling

(2015) Cuiting Lv et al.   Marine Drugs

Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment

(2015) Luc Martin   Marine Drugs

Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells

(2015) Junxiong Chen et al.   Marine Drugs

Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin

(2015) KWANG-YOUN KIM et al.   Molecular Medicine Reports

Lectins with Potential for Anti-Cancer Therapy

(2015) Tammy Yau et al.   MOLECULES

Five new iridoïd dimers from the fruits of Canthium subcordatum DC (syn. Psydrax subcordata DC)

(2015) Christelle Joubouhi et al.   Phytochemistry Letters

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues

(2015) KAZUTO TAKAHASHI et al.   Oncology Letters

Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells

(2015) Víctor García et al.   Oncotarget

Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy

(2015) Min Luo et al.   Scientific Reports

Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells

(2015) Szu-Ying Wu et al.   Biomed Research International

Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

(2015) Elżbieta Kania et al.   Biomed Research International

Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells

(2015) Zhongyuan ZHANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Molecular mechanisms of luteolin-7-O-glucoside-induced growth inhibition on human liver cancer cells: G2/M cell cycle arrest and caspase-independent apoptotic signaling pathways

(2014) Yu-Jin Hwang et al.   BMB Reports

Phase II trial of vatalanib in patients with advanced or metastatic pancreatic adenocarcinoma after first-line gemcitabine therapy (PCRT O4-001)

(2014) T. Dragovich et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

RETRACTED: Carrageenan: A natural seaweed polysaccharide and its applications

(2014) Vipul D. Prajapati et al.   CARBOHYDRATE POLYMERS

Glycyrrhizin Suppresses Lung Adenocarcinoma Cell Growth Through Inhibition of Thromboxane Synthase

(2014) Run-Yue Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions

(2014) Wei Huang et al.   FITOTERAPIA

The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells

(2014) Esther A. Guzmán et al.   INVESTIGATIONAL NEW DRUGS

Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells

(2014) Nicholas Don-Doncow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ovothiol Isolated from Sea Urchin Oocytes Induces Autophagy in the Hep-G2 Cell Line

(2014) Gian Russo et al.   Marine Drugs

In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells

(2014) Sheng-An Tang et al.   Marine Drugs

Bioactive components of Glycyrrhiza uralensis mediate drug functions and properties through regulation of CYP450 enzymes

(2014) HAO CHEN et al.   Molecular Medicine Reports

Anticancer Agents Targeted to Sirtuins

(2014) Tomohiro Kozako et al.   MOLECULES

Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

(2014) Juan Guzman   MOLECULES

The Apoptotic Effect of D Rhamnose β-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells

(2014) Lin Cheng et al.   PLoS One

Panepoxydone Targets NF-kB and FOXM1 to Inhibit Proliferation, Induce Apoptosis and Reverse Epithelial to Mesenchymal Transition in Breast Cancer

(2014) Ritu Arora et al.   PLoS One

Aaptamines from the Marine SpongeAaptossp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells

(2014) Sergey A. Dyshlovoy et al.   Biomed Research International

How to Write a Systematic Review

(2013) Joshua D. Harris et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Synthesis of novel isoflavene–propranolol hybrids as anti-tumor agents

(2013) Eugene M.H. Yee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma

(2013) N. R. Song et al.   Cancer Prevention Research

Antitumor Activity of Cucumarioside A2-2

(2013) E.S. Menchinskaya et al.   CHEMOTHERAPY

Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea

(2013) Ui Joung Youn et al.   FITOTERAPIA

Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway

(2013) JUN LIAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma

(2013) TAKAYOSHI ROKKAKU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

P38 MAP Kinase Mediates Apoptosis After Genipin Treatment in Non^|^ndash;Small-Cell Lung Cancer H1299 Cells via a Mitochondrial Apoptotic Cascade

(2013) Xue Yang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Gliotoxin Isolated from Marine Fungus Aspergillus sp. Induces Apoptosis of Human Cervical Cancer and Chondrosarcoma Cells

(2013) Van-Tinh Nguyen et al.   Marine Drugs

Antimetastatic Effect of Halichondramide, a Trisoxazole Macrolide from the Marine Sponge Chondrosia corticata, on Human Prostate Cancer Cells via Modulation of Epithelial-to-Mesenchymal Transition

(2013) Yoonho Shin et al.   Marine Drugs

Anti-Inflammatory Effect of Neoechinulin A from the Marine Fungus Eurotium sp. SF-5989 through the Suppression of NF-кB and p38 MAPK Pathways in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

(2013) Kyoung-Su Kim et al.   MOLECULES

Dichapetalins from Dichapetalum species and their cytotoxic properties

(2013) Christophe Long et al.   PHYTOCHEMISTRY

Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells

(2013) Xing Chen et al.   PLoS One

Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity

(2013) M Bury et al.   Cell Death & Disease

Linifanib

(2013)   Drugs in research & development

Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea

(2012) Ui Joung Youn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enigmatic sex disparities in cancer incidence

(2012) Gustaf Edgren et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: Signaling cascade and drug–DNA interaction

(2012) Kausik Bishayee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eclipta prostrata L. phytochemicals: Isolation, structure elucidation, and their antitumor activity

(2012) Qi-Mei Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt

(2012) SIVALOKANATHAN SARVESWARAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Biological activities of nitidine, a potential anti-malarial lead compound

(2012) Jérome Bouquet et al.   MALARIA JOURNAL

In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice

(2012) Jun Wang et al.   Marine Drugs

Liquiritigenin Inhibits Tumor Growth and Vascularization in a Mouse Model of Hela Cells

(2012) Yuxin Liu et al.   MOLECULES

Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase- and mitochondria-dependent pathways

(2012) FU-SHIN CHUEH et al.   ONCOLOGY REPORTS

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

(2012) JIA-YING XU et al.   ONCOLOGY REPORTS

Induction of apoptosis in human cervical carcinoma HeLa cells by neoechinulin A from marine-derived fungus Microsporum sp.

(2012) Isuru Wijesekara et al.   PROCESS BIOCHEMISTRY

Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells

(2012) Song Yi Bae et al.   TOXICOLOGY IN VITRO

Gender Differences in Cancer Susceptibility: An Inadequately Addressed Issue

(2012) M. Tevfik Dorak et al.   Frontiers in Genetics

The Fungi: 1, 2, 3 … 5.1 million species?

(2011) Meredith Blackwell   AMERICAN JOURNAL OF BOTANY

Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents

(2011) Aurelio Romero-Castro et al.   ARCHIVES OF PHARMACAL RESEARCH

Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors

(2011) Yunqi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways

(2011) Tingting Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway

(2011) Xinhua Pan et al.   CANCER LETTERS

Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions

(2011) Qin Zhao et al.   Journal of Zhejiang University-SCIENCE B

New Candidaspongiolides, Tedanolide Analogues That Selectively Inhibit Melanoma Cell Growth

(2011) Emily L. Whitson et al.   ORGANIC LETTERS

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

(2010) Mary-Clare Cathcart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Chemopreventive Effects of Frondanol A5, a Cucumaria frondosa Extract, against Rat Colon Carcinogenesis and Inhibition of Human Colon Cancer Cell Growth

(2010) N. B. Janakiram et al.   Cancer Prevention Research

Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway

(2010) Mi Ra Seon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway

(2010) Ya-Ling Hsu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-Pancreatic Cancer Effects of a Polar Extract From the Edible Sea Cucumber, Cucumaria frondosa

(2010) Alexandra B. Roginsky et al.   PANCREAS

Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in heLa Cells

(2010) Changwei Liu et al.   PHYTOTHERAPY RESEARCH

Glycyrol Induces Apoptosis in Human Jurkat T Cell Lymphocytes via the Fas-FasL/Caspase-8 Pathway

(2010) Eun Shin et al.   PLANTA MEDICA

L-rhamnose and L-fucose suppress cancer growth in mice

(2010) Pavel Tomsik et al.   Open Life Sciences

Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway

(2009) Jian-hui Liu et al.   ACTA PHARMACOLOGICA SINICA

Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

(2009) Marc Schumacher et al.   BIOCHEMICAL PHARMACOLOGY

Differential effects of triterpene glycosides, frondoside A and cucumarioside A2-2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells

(2009) Jun-O Jin et al.   FEBS LETTERS

c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells

(2009) Se-Jung Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Phorbaketals A, B, and C, Sesterterpenoids with a Spiroketal of Hydrobenzopyran Moiety Isolated from the Marine SpongePhorbassp.

(2009) Jung-Rae Rho et al.   ORGANIC LETTERS

Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes

(2008) Young Woo Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Judah Folkman, a pioneer in the study of angiogenesis

(2008) Domenico Ribatti   ANGIOGENESIS

New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

(2008) Min Li-Weber   CANCER TREATMENT REVIEWS

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Effect of liquiritigenin, a flavanone existed from Radix glycyrrhizae on pro-apoptotic in SMMC-7721 cells

(2008) Shi-ping Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Dichapetalin-Type Triterpenoids and Lignans from the Aerial Parts ofPhyllanthus acutissima

(2008) Patoomratana Tuchinda et al.   JOURNAL OF NATURAL PRODUCTS

Induction of Apoptosis in Human Cancer Cells by Candidaspongiolide, a Novel Sponge Polyketide

(2008) Daniela Trisciuoglio et al.   JNCI-Journal of the National Cancer Institute

Dichapetalin M from Dichapetalum madagascariensis

(2008) Dorcas Osei-Safo et al.   Phytochemistry Letters

Gliotoxin production by clinical and environmental Aspergillus fumigatus strains

(2007) Claudio Kupfahl et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist

(2007) Jennifer E. Mersereau et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY