Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling Glucose regulatory protein 78 and AMPK

(2015) Prabodh K. Kandala et al.   Oncotarget

Calcium Channel Blocker Verapamil Enhances Reticulum Stress and Death Induced by Proteasome Inhibition in Myeloma Cells

(2015) Silke Meister et al.   NEOPLASIA

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells

(2014) XIU CHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

T-Type Ca2+ Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake

(2014) Hong-Kun Rim et al.   MOLECULES

Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells

(2014) Kristen Larocque et al.   PLoS One

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

(2014) E J Park et al.   Cell Death & Disease

Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

(2014) W Qiu et al.   Cell Death & Disease

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

(2013) B. Gini et al.   CLINICAL CANCER RESEARCH

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Modulation of endoplasmic reticulum chaperone GRP78 by high glucose in hippocampus of streptozotocin-induced diabetic mice and C6 astrocytic cells

(2013) Daniella P.K. Wong et al.   NEUROCHEMISTRY INTERNATIONAL

20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells

(2013) RUI ZHANG et al.   ONCOLOGY REPORTS

Role of Intracellular Calcium in Proteasome Inhibitor-Induced Endoplasmic Reticulum Stress, Autophagy, and Cell Death

(2013) Jessica A. Williams et al.   PHARMACEUTICAL RESEARCH

mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling

(2013) Jean-Paul Decuypere et al.   PLoS One

Inhibition of Proliferation and Induction of Autophagy by Atorvastatin in PC3 Prostate Cancer Cells Correlate with Downregulation of Bcl2 and Upregulation of miR-182 and p21

(2013) Xinjian Peng et al.   PLoS One

Autophagy in tumour cell death

(2013) Robin L. Macintosh et al.   SEMINARS IN CANCER BIOLOGY

Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers11This work was partially supported by grants from DoD PCRP program (W81XWH-09-1-0455) and KUMC Valk Foundation to Dr Benyi Li, and grants from China Natural Science Foundation to Dr Benyi Li (NSFC #81172427) and Dr Jun Yang (NSFC #81101927). This project was also supported by the “Chutian Scholar” program funded by Hubei Province of China dedicated to China Three Gorges University.

(2013) Ruibao Chen et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

(2013) A Garufi et al.   Cell Death & Disease

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells

(2013) I Dando et al.   Cell Death & Disease

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells

(2013) LELE SONG et al.   Oncology Letters

CAV1/caveolin 1 enhances aerobic glycolysis in colon cancer cells via activation of SLC2A3/GLUT3 transcription

(2012) Tae-Kyu Ha et al.   Autophagy

Inhibition of T-type Ca2+ channels by endostatin attenuates human glioblastoma cell proliferation and migration

(2012) Yuan Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy

(2012) Giorgio Santoni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-MediatedGLUT3Transcription

(2012) Tae-Kyu Ha et al.   CANCER RESEARCH

Unglycosylated clusterin variant accumulates in the endoplasmic reticulum and induces cytotoxicity

(2012) Sang-Wook Kang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Growth Inhibition by miR-519 via Multiple p21-Inducing Pathways

(2012) K. Abdelmohsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer

(2012) M. Kumano et al.   MOLECULAR CANCER THERAPEUTICS

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers

(2012) Anna Krzeslak et al.   PATHOLOGY & ONCOLOGY RESEARCH

Autophagy and cancer cell metabolism

(2012) Fred Lozy et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ER stress modulates cellular metabolism

(2011) Xiaoli Wang et al.   BIOCHEMICAL JOURNAL

Basic and Clinical Research on the Therapeutic Effect of Intervention in Primary Liver Cancer by Targeted Intra-Arterial Verapamil Infusion

(2011) Fan Pingsheng et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

(2011) D Vara et al.   CELL DEATH AND DIFFERENTIATION

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis

(2011) Huiling Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Core signaling pathways of survival/death in autophagy-related cancer networks

(2011) Shu-ya Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular mechanisms of the antimetastatic activity of nuclear clusterin in prostate cancer cells

(2011) Patrizia Limonta   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells

(2011) Alexander Strigun et al.   JOURNAL OF BIOTECHNOLOGY

Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death

(2011) Hao Wu et al.   JOURNAL OF PATHOLOGY

Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostate Cancer

(2011) Anna A. Powolny et al.   JNCI-Journal of the National Cancer Institute

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis

(2010) Xiaoming Xing et al.   ACTA HISTOCHEMICA

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

(2010) Haibin Xi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Defective autophagy control by the p53 rheostat in cancer

(2010) Lorenzo Galluzzi et al.   CELL CYCLE

PI3K/Akt/mTOR Pathway Inhibitors in Cancer: A Perspective on Clinical Progress

(2010) P. Wu et al.   CURRENT MEDICINAL CHEMISTRY

Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer

(2010) Ssu-Ming Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes

(2010) W. Jia et al.   JOURNAL OF IMMUNOLOGY

Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis

(2010) Gui Fang Guo et al.   MEDICAL ONCOLOGY

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells

(2010) H L Bennett et al.   Cell Death & Disease

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell

(2009) Hai-yan Xiong et al.   CANCER LETTERS

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways

(2009) Eirini Balantinou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Glucose Consumption and Autophagy in Myeloma with the Novel Nucleoside Analogue 8-Aminoadenosine

(2009) Mala Shanmugam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

(2009) Donglei Liu et al.   MEDICAL ONCOLOGY

Effect of nifedipine on capacitive calcium entry in Jurkat T lymphocytes

(2008) Angela Colucci et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells

(2008) Yingyan Wang et al.   BMC CANCER

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy

(2008) Robert S. DiPaola et al.   PROSTATE