Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)

Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent

(2015) Xu-Dong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies

(2015) Mariya al-Rashida et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

(2015) Koji Wada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antifungal activity of ethers, alcohols, and iodohydrin derivatives of sclareol against phytopathogenic fungi in vitro

(2015) Miaofeng Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men)

(2015) Yingzhan Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29

(2015) Meilin Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High intake of heterocyclic amines from meat is associated with oxidative stress

(2015) A. M. Carvalho et al.   BRITISH JOURNAL OF NUTRITION

Tubulin Inhibitor Identification by Bioactive Conformation Alignment Pharmacophore-Guided Virtual Screening

(2015) Shanthi Nagarajan et al.   Chemical Biology & Drug Design

Antibacterial Δ1-3-Ketosteroids from the South China Sea Gorgonian CoralSubergorgia rubra

(2015) Xue-Ping Sun et al.   CHEMISTRY & BIODIVERSITY

Designing New Analogs for Streamlining the Structure of Cytotoxic Lamellarin Natural Products

(2015) Kassrin Tangdenpaisal et al.   Chemistry-An Asian Journal

Evaluating aquatic invertebrate vulnerability to insecticides based on intrinsic sensitivity, biological traits, and toxic mode of action

(2015) Andreu Rico et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Synthesis of diethyl 4-substituted-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates as a new series of inhibitors against yeast α-glucosidase

(2015) Huma Niaz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, and structure–activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds

(2015) Egor V. Verbitskiy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities

(2015) Amer M. Alanazi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice

(2015) Xue-jiao Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HPLC-SPE-NMR Characterization of Major Metabolites in Salvia fruticosa Mill. Extract with Antifungal Potential: Relevance of Carnosic Acid, Carnosol, and Hispidulin

(2015) Vassiliki Exarchou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

(2015) Juan D. Guzman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein

(2015) Erez Pery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin

(2015) Shu-Fen Liou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of Small Molecule CD40–TRAF6 Inhibitors

(2015) Barbara Zarzycka et al.   Journal of Chemical Information and Modeling

Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors

(2015) Cynthia A. Morgan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells

(2015) Guowen Ren et al.   Journal of Natural Medicines

Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes

(2015) Chieko SHIOTA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Comparative metabolism of Lappaconitine in rat and human liver microsomes and in vivo of rat using ultra high-performance liquid chromatography–quadrupole/time-of-flight mass spectrometry

(2015) Shupeng Yang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Rivaroxaban for the treatment and prevention of thromboembolic disease

(2015) Sotiris Antoniou   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica

(2015) Diaa Youssef et al.   Marine Drugs

Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs)

(2015) Marie-Therese Mackmull et al.   MOLECULAR & CELLULAR PROTEOMICS

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

(2015) Therese Ellendorff et al.   MOLECULES

Anti-tumour-promoting and thermal-induced protein denaturation inhibitory activities of β-sitosterol and lupeol isolated fromDiospyros lotusL.

(2015) Abdur Rauf et al.   NATURAL PRODUCT RESEARCH

Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, fromGrifola frondosa

(2015) Xiaoyun He et al.   NATURAL PRODUCT RESEARCH

Chemical composition, antibacterial and anticancer activities of volatile oil ofMelicope denhamiileaves

(2015) Sony George et al.   NATURAL PRODUCT RESEARCH

Antiproliferative effect of isolated isoquinoline alkaloid fromMucuna pruriensseeds in hepatic carcinoma cells

(2015) Pranesh Kumar et al.   NATURAL PRODUCT RESEARCH

Design, Synthesis and Bioassay of Novel Metal Complexes of 3-Amino-6,8-Dibromo-2-Methyl Quinazolin-4(3H)-One

(2015) Osarumwense O. Peter et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Riociguat: A Novel New Drug for Treatment of Pulmonary Hypertension

(2015) Charles T. Makowski et al.   PHARMACOTHERAPY

Diterpenoid alkaloids from Aconitum vilmorinianum

(2015) Tian-Peng Yin et al.   PHYTOCHEMISTRY

Composition and Anti-Cyanobacterial Activity of Essential Oils from Six Different Submerged Macrophytes

(2015) Hongqiang Wang et al.   POLISH JOURNAL OF ENVIRONMENTAL STUDIES

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

(2015) Anna Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

(2015) Jennifer La et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity

(2015) Tamires C. Lima et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Preparation of 2-phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents

(2015) Petr Funk et al.   RSC Advances

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

(2015) Ghania Ramdani et al.   PLoS Pathogens

Antibacterial Activity of Green Synthesis of Iron Nanoparticles UsingLawsonia inermisandGardenia jasminoidesLeaves Extract

(2015) Tayyaba Naseem et al.   Journal of Chemistry

Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity

(2015) Tamires C. Lima et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Molecular docking and inhibition studies on the interactions of Bacopa monnieri’s potent phytochemicals against pathogenic Staphylococcus aureus

(2015) Talha Bin Emran et al.   DARU-Journal of Pharmaceutical Sciences

Identification and Further Development of Potent TBK1 Inhibitors

(2014) André Richters et al.   ACS Chemical Biology

Protective and antigenotoxic effect ofUlva rigidaC. Agardh in experimental hypothyroid

(2014) Serap Celikler et al.   ACTA BIOLOGICA HUNGARICA

Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors

(2014) Emiliano Rosatelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cell death in amastigote forms of Leishmania amazonensis induced by parthenolide

(2014) Tatiana Tiuman et al.   BMC MICROBIOLOGY

Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes

(2014) Te-Chun Yang et al.   FITOTERAPIA

A 3-year review of new psychoactive substances in casework

(2014) Simon Elliott et al.   FORENSIC SCIENCE INTERNATIONAL

Pestalols A–E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum

(2014) Jian-Fan Sun et al.   JOURNAL OF ANTIBIOTICS

Identification of Small Molecule Inhibitors of Pre-mRNA Splicing

(2014) Andrea Pawellek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Potential of Naphthoquinones Leached from Leaves and Exuded from Roots of the Invasive Plant Impatiens glandulifera

(2014) Regina Ruckli et al.   JOURNAL OF CHEMICAL ECOLOGY

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches

(2014) Baptiste Villemagne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessedin vitrousing equine whole blood assays

(2014) J. R. Bauquier et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

Evaluation of Alkylating and Intercalating Properties of Mannich Bases for Cytotoxic Activity

(2014) Huseyin Istanbullu et al.   Letters in Drug Design & Discovery

Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3

(2014) Binh V Le et al.   MALARIA JOURNAL

Structures of New Phenolics Isolated from Licorice, and the Effectiveness of Licorice Phenolics on Vancomycin-Resistant Enterococci

(2014) Eerdunbayaer et al.   MOLECULES

Kavain analogues as potential analgesic agents

(2014) Elaine C. Kormann et al.   Pharmacological Reports

Fuzi Attenuates Diabetic Neuropathy in Rats and Protects Schwann Cells from Apoptosis Induced by High Glucose

(2014) Jing Han et al.   PLoS One

Phosphodiesterase 3/4 Inhibitor Zardaverine Exhibits Potent and Selective Antitumor Activity against Hepatocellular Carcinoma Both In Vitro and In Vivo Independently of Phosphodiesterase Inhibition

(2014) Liping Sun et al.   PLoS One

Analysis of endoplasmic reticulum stress in placentas of HIV-infected women treated with protease inhibitors

(2014) Ansgar Brüning et al.   REPRODUCTIVE TOXICOLOGY

Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis

(2014) Qingfei Zheng et al.   TETRAHEDRON

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Is Selectively Toxic to Primary Dopaminergic Neurons In Vitro

(2014) Amy M. Griggs et al.   TOXICOLOGICAL SCIENCES

Antitumor activity of the dietary diterpene carnosol against a panel of human cancer cell lines

(2014) Daniele Vergara et al.   Food & Function

Black cobra (Naja naja karachiensis) lysates exhibit broad-spectrum antimicrobial activities

(2014) Mehwish Sagheer et al.   Pathogens and Global Health

Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells

(2013) Jyoti Mareddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of some new 2-(3-pyridyl)-4,5-disubstituted thiazoles as potent antimicrobial agents

(2013) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemical Composition Analysis and Antibacterial Mode of Action ofTaxus CuspidataLeaf Essential Oil against Foodborne Pathogens

(2013) Vivek K. Bajpai et al.   JOURNAL OF FOOD SAFETY

Antimicrobial activities of active component isolated from Lawsonia inermis leaves and structure-activity relationships of its analogues against food-borne bacteria

(2013) Ji-Yeon Yang et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Gas Chromatography–Mass Spectrometry Confirmation of the Sensory Scent Features of the Most Commonly Consumed Agaricus bisporus and Agaricus subrufescens Exhibiting Anticancerous Traits

(2013) Júlia Győrfi et al.   JOURNAL OF MEDICINAL FOOD

Synthesis and anti-viral activities of some 3-(naphthalen-1-ylmethylene)-5-phenylfuran-2(3H)-one candidates

(2013) Eman M. Flefel et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Antiviral activity of carnosic acid against respiratory syncytial virus

(2013) Han-Bo Shin et al.   Virology Journal

A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli

(2012) Patricia L. Taylor et al.   ACS Chemical Biology

Discovery of novel inhibitors of LEDGF/p75-IN protein–protein interactions

(2012) Tino Wilson Sanchez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines

(2012) Y.L.N. Murthy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases

(2012) Pinhong Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Simple C-2-Substituted Quinolines and their Anticancer Activity

(2012) Vladimir V. Kouznetsov et al.   Letters in Drug Design & Discovery

Chemistry and Biological Activities of 1,3-Benzothiazoles

(2012) Victor Facchinetti et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

An investigation of phenylthiazole antiflaviviral agents

(2011) Abdelrahman S. Mayhoub et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles

(2011) Ebraheem Abdu Musad et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Norovirus Infection-Multivalent Entry Inhibitor Design Based on NMR Experiments

(2011) Christoph Rademacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cockroaches and locusts: physicians’ answer to infectious diseases

(2011) Simon Lee et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Novel Inhibitors of Trihydroxynaphthalene Reductase with Antifungal Activity Identified by Ligand-Based and Structure-Based Virtual Screening

(2011) Mojca Brunskole Švegelj et al.   Journal of Chemical Information and Modeling

Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity

(2011) Mymoona Akhter et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

(2011) Nathan A. Lack et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Prospect of Newly Synthesized 1,3-Thiazole Derivatives

(2011) Bassem Sadek et al.   MOLECULES

Comparison of antimicrobial activities of naphthoquinones fromImpatiens balsamina

(2011) Athip Sakunphueak et al.   NATURAL PRODUCT RESEARCH

Synthesis and antiviral activity of several quinoline derivatives

(2011) M. N. Zemtsova et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Toward the Discovery of New Agents Able to Inhibit the Expression of Microsomal Prostaglandin E Synthase-1 Enzyme as Promising Tools in Drug Development

(2010) Rosa De Simone et al.   Chemical Biology & Drug Design

Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl)phenyl]acetamide derivatives and evaluation of their anticancer activity

(2010) Yusuf Özkay et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Newer antibacterial drugs for a new century

(2010) Gina Devasahayam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Synthesis and biological evaluation of 4-thiazolidinone derivatives as antitubercular and antimicrobial agents

(2010) Pushkal Samadhiya et al.   Arabian Journal of Chemistry

Identification and characterization of inhibitors of West Nile virus

(2009) Francesc Puig-Basagoiti et al.   ANTIVIRAL RESEARCH

N-(Indazolyl)benzamido Derivatives as CDK1 Inhibitors: Design, Synthesis, Biological Activity, and Molecular Docking Studies

(2009) Demetrio Raffa et al.   ARCHIV DER PHARMAZIE

Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp.

(2009) Huayue Li et al.   ARCHIVES OF PHARMACAL RESEARCH

6,7-Dihydroxy-3,4-Dihydroisoquinoline: A Novel Inhibitor of Nuclear Factor-κB and in vitro Invasion in Murine Mammary Cancer Cells

(2009) Francisco N. Alvarez et al.   CHEMOTHERAPY

What is MRSA?

(2009) A. Pantosti et al.   EUROPEAN RESPIRATORY JOURNAL

Peptidomic survey of the locust neuroendocrine system

(2009) Elke Clynen et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Acanthamoeba affects the integrity of human brain microvascular endothelial cells and degrades the tight junction proteins

(2009) Naveed Ahmed Khan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity

(2009) Stefan Wirth et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

(2009) Jesus M. Ontoria et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted reaction of 2,3-dichloronaphthoquinone with aminopyridines

(2009) Ricardo A. Tapia et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties

(2008) Emmanuelle Braud et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels–Alder reactions

(2008) Carlos M. Meléndez Gómez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones

(2008) J.P. Rappai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Acylated and N,N′-diacylated imidazolidine-2-thione derivatives and N,N′-diacylated tetrahydropyrimidine-2(1H)-thione analogues: Synthesis and antiproliferative activity

(2008) Sara Cesarini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation

(2008) M.M. Alam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Lysates of Locusta migratoria brain exhibit potent broad-spectrum antibacterial activity

(2008) N. A. Khan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY