Potential Anticancer Properties and Mechanisms of Action of Formononetin

Lavatera critica controls systemic insulin resistance by ameliorating adipose tissue inflammation and oxidative stress using bioactive compounds identified by GC–MS

(2018) Chinnadurai Veeramani et al.   BIOMEDICINE & PHARMACOTHERAPY

Aucubin protects against lipopolysaccharide-induced acute pulmonary injury through regulating Nrf2 and AMPK pathways

(2018) Yan-Ling Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway

(2018) Ruijuan Zhou et al.   BMC Complementary and Alternative Medicine

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation

(2018) Sunwoo Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A rapid method for sensitive profiling of bioactive triterpene and flavonoid from Astragalus mongholicus and Astragalus membranaceus by ultra-pressure liquid chromatography with tandem mass spectrometry

(2018) Yang Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Separation and characterization of homopipecolic acid isoflavonoid ester derivatives isolated from Ononis spinosa L. root

(2018) Nóra Gampe et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells

(2018) Jing Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The photoprotective and anti-inflammatory activity of red propolis extract in rats

(2018) C.M. Batista et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway

(2018) Dacheng Wu et al.   MEDIATORS OF INFLAMMATION

Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα

(2018) Jian Chen et al.   MOLECULAR CARCINOGENESIS

Cell shape can be uncoupled from formononetin induction in a novel cell line from Callerya speciosa

(2018) Fei Qiao et al.   PLANT CELL REPORTS

Effects of existential interventions on spiritual, psychological and physical well-being in adult patients with cancer: systematic review and meta-analysis of randomized controlled trials

(2018) Natalie Bauereiß et al.   PSYCHO-ONCOLOGY

Red Clover (Trifolium pratense) and Zigzag Clover (T. medium) – A Picture of Genomic Similarities and Differences

(2018) Jana Dluhošová et al.   Frontiers in Plant Science

Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis

(2018) Ly Thi Huong Nguyen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Correction to: Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter

(2018) Lucie Navrátilová et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

(2017) Dong-Jun Fu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fraxinus: A Plant with Versatile Pharmacological and Biological Activities

(2017) Iqra Sarfraz et al.   Evidence-based Complementary and Alternative Medicine

Chinese medicine Bu-Fei decoction attenuates epithelial-mesenchymal transition of non-small cell lung cancer via inhibition of transforming growth factor β1 signaling pathway in vitro and in vivo

(2017) Xi-Ran He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Isoflavones from green vegetable soya beans and their antimicrobial and antioxidant activities

(2017) Taoyun Wang et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

A comparative study on the effect of promoting the osteogenic function of osteoblasts using isoflavones from Radix Astragalus

(2017) Xianghe Kong et al.   PHYTOTHERAPY RESEARCH

Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN

(2017) Yiying Wu et al.   Food & Function

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp

(2016) Michelline Viviane Marques das Neves et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells

(2016) Qiuhui Hu et al.   FOOD CHEMISTRY

Formononetin upregulates nitric oxide synthase in arterial endothelium through estrogen receptors and MAPK pathways

(2016) Tao Sun et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1/2 expression

(2016) Yan Hong Guo et al.   PHARMACEUTICAL BIOLOGY

Formononetin Induces Apoptosis of Human Osteosarcoma Cell Line U2OS by Regulating the Expression of Bcl-2, Bax and MiR-375 In Vitro and In Vivo

(2015) Wei Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Biochanin A Promotes Proliferation that Involves a Feedback Loop of MicroRNA-375 and Estrogen Receptor Alpha in Breast Cancer Cells

(2015) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

PI3K and AKT: Unfaithful Partners in Cancer

(2015) Seraina Faes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triterpene and Flavonoid Biosynthesis and Metabolic Profiling of Hairy Roots, Adventitious Roots, and Seedling Roots of Astragalus membranaceus

(2015) Yun Ji Park et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Killing cancer with platycodin D through multiple mechanisms

(2015) Muhammad Khan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Retracted: Formononetin promotes proliferation that involves a feedback loop of microRNA-375 and estrogen receptor alpha in estrogen receptor-positive cells

(2015) Jian Chen et al.   MOLECULAR CARCINOGENESIS

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Hydroalcoholic extract of red propolis promotes functional recovery and axon repair after sciatic nerve injury in rats

(2015) Roberta Almeida Barbosa et al.   PHARMACEUTICAL BIOLOGY

Acute toxicity of sodium formononetin-3′-sulphonate (Sul-F) in Sprague-Dawley rats and Beagle dogs

(2015) Guisheng Li et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Up-regulating of RASD1 and Apoptosis of DU-145 Human Prostate Cancer Cells Induced by Formononetin in Vitro

(2014) Xiao-Jia Liu et al.   Asian Pacific Journal of Cancer Prevention

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

The Proapoptotic Effect of Formononetin in Human Osteosarcoma Cells: Involvement of Inactivation of ERK and Akt Pathways

(2014) Yun Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Formononetin Promotes Cell Cycle Arrest via Downregulation of Akt/Cyclin D1/CDK4 in Human Prostate Cancer Cells

(2014) Tianyu Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Natural Products As Antimitotic Agents

(2014) Stefano Dall'Acqua   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Formononetin Inhibits Migration and Invasion of MDA-MB-231 and 4T1 Breast Cancer Cells by Suppressing MMP-2 and MMP-9 Through PI3K/AKT Signaling Pathways

(2014) R. Zhou et al.   HORMONE AND METABOLIC RESEARCH

Screening Active Components from Yu-Ping-Feng-San for Regulating Initiative Key Factors in Allergic Sensitization

(2014) Dandan Shen et al.   PLoS One

Editorial: Plant Derived Secondary Metabolites as Anti-Cancer Agents

(2013) Diwan Rawat et al.   Anti-Cancer Agents in Medicinal Chemistry

Estrogen Receptor Beta-Mediated Proliferative Inhibition and Apoptosis in Human Breast Cancer by Calycosin and Formononetin

(2013) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Induction of Apoptosis by Costunolide in Bladder Cancer Cells is Mediated through ROS Generation and Mitochondrial Dysfunction

(2013) Azhar Rasul et al.   MOLECULES

Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway

(2013) Wen-Jun Huang et al.   PHARMACEUTICAL BIOLOGY

In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa

(2013) Yue-mei Jin et al.   TUMOR BIOLOGY

Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

(2013) Azhar Rasul et al.   Biomed Research International

Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis

(2012) Azhar Rasul et al.   APOPTOSIS

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

(2012) Libero Santarpia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Formononetin-induced Apoptosis by Activation of Ras/p38 Mitogen-activated Protein Kinase in Estrogen Receptor-positive Human Breast Cancer Cells

(2012) J. Chen et al.   HORMONE AND METABOLIC RESEARCH

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Drug Discovery from Marine Microbes

(2012) William H. Gerwick et al.   MICROBIAL ECOLOGY

Natural products: An evolving role in future drug discovery

(2011) Bhuwan B. Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Isoflavones as Apoptosis Inducers in Human Hepatoma HuH-7 Cells

(2011) Tayyab A. Mansoor et al.   PHYTOTHERAPY RESEARCH

Yeast α-Glucosidase Inhibition by Isoflavones from Plants of Leguminosae as an in Vitro Alternative to Acarbose

(2010) Chun Whan Choi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pycnanthulignenes A−D, Antimicrobial Cyclolignene Derivatives from the Roots ofPycnanthus angolensis

(2010) Eric C. N. Nono et al.   JOURNAL OF NATURAL PRODUCTS

Isoflavones isolated from red clover (Trifolium pratense) inhibit smooth muscle contraction of the isolated rat prostate gland

(2010) A. Brandli et al.   PHYTOMEDICINE

20S proteasome inhibitory activity of flavonoids isolated from Spatholobus suberectus

(2010) Sang Hee Shim   PHYTOTHERAPY RESEARCH

Comparative Study on Separation and Purification of Isoflavones from the Seeds and Sprouts of Chickpea by High-Speed Countercurrent Chromatography

(2009) Qiaoying Lv et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways

(2009) Jian-Hong Wu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quantitative Determination of Triterpenoids and Formononetin in Rhizomes of Black Cohosh (Actaea racemosa) and Dietary Supplements by Using UPLC-UV/ELS Detection and Identification by UPLC-MS

(2008) Bharathi Avula et al.   PLANTA MEDICA