ALS Pathogenesis and Therapeutic Approaches: The Role of Mesenchymal Stem Cells and Extracellular Vesicles

Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

(2016) Mijung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Physiological and pathological impact of exosomes of adipose tissue

(2016) Yan Zhang et al.   CELL PROLIFERATION

Emerging molecular biomarker targets for amyotrophic lateral sclerosis

(2016) Júlia Costa et al.   CLINICA CHIMICA ACTA

Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's diseasein vitromodel

(2016) Mijung Lee et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

(2016) Roberta Bonafede et al.   EXPERIMENTAL CELL RESEARCH

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes

(2016) Pasquina Marzola et al.   International Journal of Nanomedicine

Exosomes as a potential novel therapeutic tools against neurodegenerative diseases

(2016) Akvilė Jarmalavičiūtė et al.   PHARMACOLOGICAL RESEARCH

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

(2016) Sarah J. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALS: A bucket of genes, environment, metabolism and unknown ingredients

(2016) Mónica Zufiría et al.   PROGRESS IN NEUROBIOLOGY

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS)

(2015) Amanda M. Haidet-Phillips et al.   BRAIN RESEARCH

The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus

(2015) Yu. N. Rushkevich et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Murine adipose-derived mesenchymal stromal cell vesicles: in vitro clues for neuroprotective and neuroregenerative approaches

(2015) Alessia Farinazzo et al.   CYTOTHERAPY

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

(2015) Akvilė Jarmalavičiūtė et al.   CYTOTHERAPY

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

An Assessment of Possible Neuropathology and Clinical Relationships in 46 Sporadic Amyotrophic Lateral Sclerosis Patient Autopsies

(2015) Grant Coan et al.   Neurodegenerative Diseases

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS

(2015) L. Comley et al.   NEUROSCIENCE

Mesenchymal stem cell exosomes

(2015) Ruenn Chai Lai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gene therapy for neurodegenerative diseases

(2015) Deirdre M. O’Connor et al.   TRENDS IN MOLECULAR MEDICINE

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Risk factors for amyotrophic lateral sclerosis

(2015) Fang Fang et al.   Clinical Epidemiology

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation

(2014) Irene Faravelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis

(2014) Marina Boido et al.   CYTOTHERAPY

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

(2014) Steve Vucic et al.   TRENDS IN NEUROSCIENCES

Retroviruses and amyotrophic lateral sclerosis

(2013) Tariq Alfahad et al.   ANTIVIRAL RESEARCH

Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes

(2013) Marie Maumus et al.   BIOCHIMIE

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Stem cell therapy in amyotrophic lateral sclerosis

(2013) Rokhsareh Meamar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

(2013) Aya D. Pusic et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased premorbid physical activity and amyotrophic lateral sclerosis: born to run rather than run to death, or a seductive myth?

(2013) M. R. Turner   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

Autoimmune disease preceding amyotrophic lateral sclerosis: An epidemiologic study

(2013) M. R. Turner et al.   NEUROLOGY

Excitation BolsTORs Motor Neurons in ALS Mice

(2013) Mark P. Mattson   NEURON

Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model

(2013) S. Marconi et al.   NEUROSCIENCE

Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

(2013) Cheryl CY Li et al.   RNA Biology

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1 G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

(2012) Jae Chul Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Understanding ALS: new therapeutic approaches

(2012) Antonio Musarò   FEBS Journal

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

(2012) G. M. Morotz et al.   HUMAN MOLECULAR GENETICS

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

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(2012) Antonio Uccelli et al.   MOLECULAR MEDICINE

Therapeutic potential of mesenchymal stem cell-derived microvesicles

(2012) L. Biancone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Intracerebroventricular Injection of Encapsulated Human Mesenchymal Cells Producing Glucagon-Like Peptide 1 Prolongs Survival in a Mouse Model of ALS

(2012) Sarah Knippenberg et al.   PLoS One

Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

(2012) Miguel Blanquer et al.   STEM CELLS

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy

(2012) Serena Rubina Baglio et al.   Frontiers in Physiology

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Stem Cell Transplantation in Amyotrophic Lateral Sclerosis Patients: Methodological Approach, Safety, and Feasibility

(2011) Héctor R. Martínez et al.   CELL TRANSPLANTATION

Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

(2011) Serhiy Forostyak et al.   CYTOTHERAPY

Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study

(2011) Letizia Mazzini et al.   CYTOTHERAPY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

TDP-43 and FUS: a nuclear affair

(2011) Dorothee Dormann et al.   TRENDS IN NEUROSCIENCES

The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials

(2010) Ettore Beghi et al.   Amyotrophic Lateral Sclerosis

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters

(2010) B. Gyorgy et al.   BLOOD

Motor neuron trophic factors: Therapeutic use in ALS?

(2010) Thomas W. Gould et al.   BRAIN RESEARCH REVIEWS

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs

(2010) Federica Collino et al.   PLoS One

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

(2009) J. Pablo et al.   ACTA NEUROLOGICA SCANDINAVICA

Mitochondrial Function, Morphology, and Axonal Transport in Amyotrophic Lateral Sclerosis

(2009) Jordi Magrané et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal intermediate filaments and neurodegenerative disorders

(2009) Rodolphe Perrot et al.   BRAIN RESEARCH BULLETIN

Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients

(2009) Hector R. Martinez et al.   CYTOTHERAPY

Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial

(2009) L. Mazzini et al.   EXPERIMENTAL NEUROLOGY

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis

(2009) Cédric Boucherie et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice

(2009) Heejaung Kim et al.   NEUROSCIENCE LETTERS

Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up

(2008) H. Deda et al.   CYTOTHERAPY

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

(2008) Angelo C Lepore et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE