Cellular pathways influenced by protein arginine methylation: Implications for cancer

MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage

(2021) Peter Kalev et al.   CANCER CELL

m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region

(2021) Zhihao Wang et al.   EMBO JOURNAL

CARM1 regulates replication fork speed and stress response by stimulating PARP1

(2021) Marie-Michelle Genois et al.   MOLECULAR CELL

CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator

(2021) Samyuktha Suresh et al.   TRENDS IN CELL BIOLOGY

Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5‐MEP50 Complex

(2021) Herbert Waldmann et al.   CHEMBIOCHEM

BRCA2 promotes R‐loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination

(2021) Gaetana Sessa et al.   EMBO JOURNAL

Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells

(2021) Claudia Dominici et al.   Clinical Epigenetics

Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators

(2021) Jiakai Hou et al.   Journal for ImmunoTherapy of Cancer

PRMT1 promotes the tumor suppressor function of p14 ARF and is indicative for pancreatic cancer prognosis

(2021) Antje Repenning et al.   EMBO JOURNAL

Protein arginine methylation: from enigmatic functions to therapeutic targeting

(2021) Qin Wu et al.   NATURE REVIEWS DRUG DISCOVERY

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

(2021) Bing Yao et al.   Genome Medicine

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response

(2021) Dapeng Ma et al.   Science Advances

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

(2021) Sydney X. Lu et al.   CELL

Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors

(2021) Ernesto Guccione et al.   CURRENT OPINION IN PHARMACOLOGY

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

(2021) Ting Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel PRMT7 mutation in a rare case of dysmorphism and intellectual disability

(2021) Jessie Poquérusse et al.   JOURNAL OF HUMAN GENETICS

Molecular basis for substrate recruitment to the PRMT5 methylosome

(2021) Kathleen M. Mulvaney et al.   MOLECULAR CELL

Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

(2021) Junji Zhu et al.   MOLECULAR CELL

Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

(2021) Xiaona Liu et al.   Nature Communications

Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

(2021) Xiawei Huang et al.   Nature Communications

Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects

(2021) Ting Cai et al.   Cell Reports

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

(2021) Maria Pilar Sanchez-Bailon et al.   Nature Communications

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

(2020) Sergey Karakashev et al.   CANCER CELL

PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation

(2020) Seul Kim et al.   Nature Communications

A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5

(2020) Benjamin M. Lorton et al.   BIOCHEMISTRY

The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma

(2020) Michael Schonfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

(2020) Magdalena M. Szewczyk et al.   Nature Communications

OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation

(2020) Mingyi Yang et al.   Cell Reports

Zebrafish prmt3 negatively regulates antiviral responses

(2020) Junji Zhu et al.   FASEB JOURNAL

Discovery of First-in-class Protein Arginine Methyltransferase 5 (PRMT5) Degraders

(2020) Yudao Shen et al.   JOURNAL OF MEDICINAL CHEMISTRY

METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

(2020) Canfeng Zhang et al.   MOLECULAR CELL

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

(2020) Hyungsoo Kim et al.   Science Translational Medicine

Combining protein arginine methyltransferase inhibitor and anti-programmed death-ligand-1 inhibits pancreatic cancer progression

(2020) Nan-Nan Zheng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

(2020) Friederike Pastore et al.   Cancer Discovery

PRMT1-p53 Pathway Controls Epicardial EMT and Invasion

(2020) Olan Jackson-Weaver et al.   Cell Reports

Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

(2020) Oscar D Villarreal et al.   Life Science Alliance

PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation

(2020) Guohui Hu et al.   EXPERIMENTAL CELL RESEARCH

Arginine methylation of APE1 promotes its mitochondrial translocation to protect cells from oxidative damage

(2020) Yilan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development

(2020) Misuzu Hashimoto et al.   JOURNAL OF NEUROCHEMISTRY

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

(2020) Xiaolong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Arginine Methyltransferase 5 in T Lymphocyte Biology

(2020) Shouvonik Sengupta et al.   TRENDS IN IMMUNOLOGY

The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions

(2020) Baskar Chakrapani et al.   Life Science Alliance

PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells

(2019) Darren Qiancheng Tan et al.   Cell Reports

PRMT1 loss sensitizes cells to PRMT5 inhibition

(2019) Guozhen Gao et al.   NUCLEIC ACIDS RESEARCH

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation

(2019) Nasim Haghandish et al.   MOLECULAR BIOLOGY OF THE CELL

PRMT7 as a unique member of the protein arginine methyltransferase family: A review

(2019) Kanishk Jain et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

(2019) Daniele Musiani et al.   Science Signaling

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

(2019) Andrew Fedoriw et al.   CANCER CELL

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level

(2019) Sunil Kumar Tewary et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Arginine methylation of the DDX 5 helicase RGG / RG motif by PRMT 5 regulates resolution of RNA:DNA hybrids

(2019) Sofiane Y Mersaoui et al.   EMBO JOURNAL

The regulation, functions and clinical relevance of arginine methylation

(2019) Ernesto Guccione et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

(2019) Jia Yi Fong et al.   CANCER CELL

A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

(2019) Changzheng Du et al.   Cell Reports

Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid‐inducible gene‐I‐like receptor signaling

(2019) Junji Zhu et al.   FASEB JOURNAL

Black carp PRMT6 inhibits TBK1-IRF3/7 signaling during the antiviral innate immune activation

(2019) Yuanyuan Jiang et al.   FISH & SHELLFISH IMMUNOLOGY

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

(2019) Aliaksandra Radzisheuskaya et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

(2019) Lixue Cao et al.   Nature Communications

UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

(2019) Juan Dong et al.   Nature Communications

PRMT1 Is Required for the Maintenance of Mature β-Cell Identity

(2019) Hyunki Kim et al.   DIABETES

Switches in histone modifications epigenetically control vitamin D3‐dependent transcriptional upregulation of the CYP24A1 gene in osteoblastic cells

(2019) Daniel Moena et al.   JOURNAL OF CELLULAR PHYSIOLOGY

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

(2019) Abdulkadir Abakir et al.   NATURE GENETICS

The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1–IRF3 signaling

(2018) Hua Zhang et al.   Cellular & Molecular Immunology

Expanding the clinical and molecular spectrum of PRMT7 mutations: 3 additional patients and review

(2018) E. Agolini et al.   CLINICAL GENETICS

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis

(2018) Y. Gou et al.   JOURNAL OF DENTAL RESEARCH

PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5–WDR77/CRL4B complex to promote tumorigenesis

(2018) Ruiqiong Liu et al.   NUCLEIC ACIDS RESEARCH

PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes

(2018) Ishita Rehman et al.   NUCLEIC ACIDS RESEARCH

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

(2018) Charles Vadnais et al.   Nature Communications

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

(2018) Sarah V. Gerhart et al.   Scientific Reports

Multiple Arginine Residues Are Methylated in Drosophila Mre11 and Required for Survival Following Ionizing Radiation

(2018) Qing Yuan et al.   G3-Genes Genomes Genetics

PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression

(2018) Satya K. Kota et al.   BONE

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

(2018) Pierre-Jacques Hamard et al.   Cell Reports

PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

(2018) Feng Dong et al.   Nature Communications

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth

(2017) Hironari Tamiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML

(2017) S Kaushik et al.   LEUKEMIA

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

(2017) Thomas L. Clarke et al.   MOLECULAR CELL

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases

(2017) Kanishk Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel SHARPIN-PRMT5-H3R2me1 axis is essential for lung cancer cell invasion

(2017) Tingxiong Fu et al.   Oncotarget

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

(2017) Kelly Chiang et al.   Cell Reports

Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells

(2017) Nithya Narayanan et al.   Cell Discovery

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

(2016) Ngai Cheung et al.   CANCER CELL

The Role of Protein Arginine Methyltransferases in Inflammatory Responses

(2016) Ji Hye Kim et al.   MEDIATORS OF INFLAMMATION

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

(2016) H Chen et al.   ONCOGENE

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

(2016) Konstantinos J. Mavrakis et al.   SCIENCE

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

(2016) Louise J. Walport et al.   Nature Communications

PRMT7 Preserves Satellite Cell Regenerative Capacity

(2016) Roméo Sébastien Blanc et al.   Cell Reports

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

(2016) Katya Marjon et al.   Cell Reports

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

Effect of methylation on the side-chain pKavalue of arginine

(2015) Marina Evich et al.   PROTEIN SCIENCE

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

(2015) Yanzhong Yang et al.   Nature Communications

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

(2015) Dong Hu et al.   Nature Communications

Readers of histone methylarginine marks

(2014) Sitaram Gayatri et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats

(2014) Morio Hasegawa et al.   FEBS LETTERS

Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

(2014) Yanzhong Yang et al.   MOLECULAR CELL

Structural and Functional Coordination of DNA and Histone Methylation

(2014) X. Cheng   Cold Spring Harbor Perspectives in Biology

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

(2013) M. Bezzi et al.   GENES & DEVELOPMENT

Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions

(2013) You Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

(2013) Meng-Chiao Ho et al.   PLoS One

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

(2013) Surbhi Dhar et al.   Scientific Reports

Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7

(2013) Vincent Cura et al.   Acta Crystallographica Section F-Structural Biology Communications

Carbon-Oxygen Hydrogen Bonding in Biological Structure and Function

(2012) Scott Horowitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation

(2011) Fan Liu et al.   CANCER CELL

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

(2011) Zhenbao Yu et al.   CELL RESEARCH

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2

(2011) Qin Guo et al.   Molecular BioSystems

Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage

(2011) Wei He et al.   NUCLEIC ACIDS RESEARCH

Methylation of H2AR29 is a novel repressive PRMT6 target

(2011) Tanja Waldmann et al.   Epigenetics & Chromatin

TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks

(2010) Yanzhong Yang et al.   MOLECULAR CELL

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

(2010) Zhigang Guo et al.   Nature Chemical Biology

Histone demethylases in development and disease

(2010) Marianne Terndrup Pedersen et al.   TRENDS IN CELL BIOLOGY

A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation

(2009) Z. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE