Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

(2021) Shan Lu et al.   Nature Communications

SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production

(2021) Lingling Luo et al.   Science Bulletin

SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region

(2021) Jia Wang et al.   Cell Discovery

In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs

(2021) Lei Sun et al.   CELL

The Role of the SARS-CoV-2 S-Protein Glycosylation in the Interaction of SARS-CoV-2/ACE2 and Immunological Responses

(2021) Eleazar Ramírez Hernández et al.   VIRAL IMMUNOLOGY

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

(2021) Yunkai Zhu et al.   Nature Communications

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

(2021) Bo Gao et al.   PLoS Pathogens

The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins

(2021) Kristina V. Tugaeva et al.   JOURNAL OF MOLECULAR BIOLOGY

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

(2021) Jasmine Cubuk et al.   Nature Communications

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design

(2020) Shan-Meng Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Detection of Nucleocapsid Antibody to SARS-CoV-2 is More Sensitive than Antibody to Spike Protein in COVID-19 Patients

(2020) Peter D Burbelo et al.   JOURNAL OF INFECTIOUS DISEASES

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

(2020) Magdalena M. Szewczyk et al.   Nature Communications

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

(2020) Sisi Kang et al.   Acta Pharmaceutica Sinica B

Discovery of First-in-class Protein Arginine Methyltransferase 5 (PRMT5) Degraders

(2020) Yudao Shen et al.   JOURNAL OF MEDICINAL CHEMISTRY

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Architecture and self‐assembly of the SARS‐CoV ‐2 nucleocapsid protein

(2020) Qiaozhen Ye et al.   PROTEIN SCIENCE

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA

(2020) Hui Chen et al.   CELL RESEARCH

Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review

(2020) Zahra Noorimotlagh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation

(2020) Aldo Barrera et al.   NUCLEIC ACIDS RESEARCH

G3BP1 controls the senescence-associated secretome and its impact on cancer progression

(2020) Amr Omer et al.   Nature Communications

SR/RS Motifs as Critical Determinants of Coronavirus Life Cycle

(2020) Eleni Nikolakaki et al.   Frontiers in Molecular Biosciences

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

(2020) William M. Schneider et al.   CELL

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

(2020) Theodora Myrto Perdikari et al.   EMBO JOURNAL

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

(2020) Christopher R. Carlson et al.   MOLECULAR CELL

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

(2020) Christiane Iserman et al.   MOLECULAR CELL

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

(2020) Adriana Savastano et al.   Nature Communications

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

(2020) Dhurvas Chandrasekaran Dinesh et al.   PLoS Pathogens

UBAP2L arginine methylation by PRMT1 modulates stress granule assembly

(2019) Chuyu Huang et al.   CELL DEATH AND DIFFERENTIATION

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

(2019) Andrew Fedoriw et al.   CANCER CELL

The regulation, functions and clinical relevance of arginine methylation

(2019) Ernesto Guccione et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PRMTs and Arginine Methylation: Cancer’s Best-Kept Secret?

(2019) James Jarrold et al.   TRENDS IN MOLECULAR MEDICINE

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag

(2018) Joris Paris et al.   Retrovirology

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

(2018) Kazuhide Nakayama et al.   Oncotarget

Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication

(2018) Keisuke Nakagawa et al.   JOURNAL OF VIROLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Methylarginines within the RGG-Motif Region of hnRNP A1 Affect Its IRES Trans -Acting Factor Activity and Are Required for hnRNP A1 Stress Granule Localization and Formation

(2017) Michael L. Wall et al.   JOURNAL OF MOLECULAR BIOLOGY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core

(2017) Barbora Lubyova et al.   PLoS One

Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly

(2016) Wei-Chih Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

(2016) Huib H. Rabouw et al.   PLoS Pathogens

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

(2015) Mohammad S. Eram et al.   ACS Chemical Biology

Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis

(2015) Jingwen Song et al.   MOLECULAR AND CELLULAR BIOLOGY

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation

(2015) Khondker Ayesha Akter et al.   TUMOR BIOLOGY

Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage

(2015) Gayathri Gurunathan et al.   Scientific Reports

Readers of histone methylarginine marks

(2014) Sitaram Gayatri et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription

(2014) Chia-Hsin Wu et al.   Cell Host & Microbe

Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

(2014) Yanzhong Yang et al.   MOLECULAR CELL

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions

(2013) You Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

Protein arginine methylation of SERBP1 by protein arginine methyltransferase 1 affects cytoplasmic/nuclear distribution

(2012) Yu-Jen Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of stress granules in virus systems

(2012) James P. White et al.   TRENDS IN MICROBIOLOGY

Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

(2011) Jung-Mao Hsu et al.   NATURE CELL BIOLOGY

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Group-specific structural features of the 5′-proximal sequences of coronavirus genomic RNAs

(2010) Shih-Cheng Chen et al.   VIROLOGY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

(2008) Tsui-Yi Peng et al.   FEBS Journal

Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP

(2008) Bastian Linder et al.   HUMAN MOLECULAR GENETICS

TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules

(2008) I. Goulet et al.   HUMAN MOLECULAR GENETICS

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication

(2008) Chia-Hsin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL