Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

CB1receptor signaling regulates social anxiety and memory

(2013) Y. Litvin et al.   GENES BRAIN AND BEHAVIOR

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

Metabotropic Glutamate Receptor I (mGluR1) Antagonism Impairs Cocaine-Induced Conditioned Place Preference via Inhibition of Protein Synthesis

(2013) Fei Yu et al.   NEUROPSYCHOPHARMACOLOGY

A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

(2012) Justin R. Piro et al.   Cell Reports

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

(2012) Rongqing Chen et al.   Cell Reports

Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses

(2011) Arnau Busquets-Garcia et al.   BIOLOGICAL PSYCHIATRY

Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats

(2011) Wen Hu et al.   BRAIN RESEARCH BULLETIN

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

(2011) Jason M. Dwyer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Extracellular Signal-Regulated Kinase Signaling in the Ventral Tegmental Area Mediates Cocaine-Induced Synaptic Plasticity and Rewarding Effects

(2011) B. Pan et al.   JOURNAL OF NEUROSCIENCE

Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation

(2011) Meina Wang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Reversible Gating of Endocannabinoid Plasticity in the Amygdala by Chronic Stress: A Potential Role for Monoacylglycerol Lipase Inhibition in the Prevention of Stress-Induced Behavioral Adaptation

(2011) Joshua J Sumislawski et al.   NEUROPSYCHOPHARMACOLOGY

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

(2011) Natale R. Sciolino et al.   PHARMACOLOGICAL RESEARCH

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

(2010) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

Depression-like phenotype following chronic CB1 receptor antagonism

(2010) Chad E. Beyer et al.   NEUROBIOLOGY OF DISEASE

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

(2010) Wei Wang et al.   NEUROPSYCHOPHARMACOLOGY

A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy

(2010) Sarah A. Eisenstein et al.   PHARMACOLOGICAL RESEARCH

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats

(2009) Christian G. Reich et al.   BEHAVIOURAL BRAIN RESEARCH

Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

(2009) Jonathan Z. Long et al.   CHEMISTRY & BIOLOGY

Endocannabinoid signals in the control of emotion

(2009) Beat Lutz   CURRENT OPINION IN PHARMACOLOGY

Endocannabinoids in the Treatment of Mood Disorders: Evidence from Animal Models

(2009) Francis Rodriguez Bambico et al.   CURRENT PHARMACEUTICAL DESIGN

Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling

(2009) B. Pan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

(2009) Emma Puighermanal et al.   NATURE NEUROSCIENCE

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The psychiatric side-effects of rimonabant

(2009) Fabrício A. Moreira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants

(2009) Matthew N. Hill et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

(2008) M. Hill et al.   PHARMACOPSYCHIATRY

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved?

(2008) F. A. Moreira et al.   NEURAL PLASTICITY

The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

(2007) Maria Scherma et al.   NEUROPHARMACOLOGY