Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy

Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation

(2020) Qiong Cheng et al.   ACTA PHARMACOLOGICA SINICA

Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway

(2020) Xinhui Lin et al.   LIFE SCIENCES

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

(2019) David A. Loeffler   Frontiers in Aging Neuroscience

Protective effects of pyrroloquinoline quinone against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway

(2019) Ziqiang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Involvement of Akt/mTOR in the Neurotoxicity of Rotenone-Induced Parkinson’s Disease Models

(2019) Yu Zhang et al.   International Journal of Environmental Research and Public Health

Autophagy and proinflammatory cytokines: Interactions and clinical implications

(2018) Yun Ge et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

(2018) Kathryn M. Lenz et al.   Frontiers in Immunology

Mitochondrial regulation by pyrroloquinoline quinone prevents rotenone-induced neurotoxicity in Parkinson’s disease models

(2018) Jinli Lu et al.   NEUROSCIENCE LETTERS

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

(2018) Yoshikuni Tabata et al.   Stem Cell Reports

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy

(2017) Yanran Liang et al.   NEUROTOXICOLOGY

Autophagy and Autophagy-Related Proteins in CNS Autoimmunity

(2017) Christian W. Keller et al.   Frontiers in Immunology

Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

(2017) Claudio Bussi et al.   Scientific Reports

Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease

(2016) Qi Zhang et al.   NEUROPHARMACOLOGY

The role of autophagy in modulation of neuroinflammation in microglia

(2016) P. Su et al.   NEUROSCIENCE

Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules

(2016) Shen Dai et al.   Cell Death & Disease

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease

(2016) Xiao-Yan Qin et al.   JAMA Neurology

Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease

(2016) Hayate Javed et al.   Frontiers in Neuroscience

Neuroinflammation in the pathophysiology of Parkinson’s disease and therapeutic evidence of anti-inflammatory drugs

(2015) Taysa Bervian Bassani et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

Pyrroloquinoline Quinone Decelerates Rheumatoid Arthritis Progression by Inhibiting Inflammatory Responses and Joint Destruction via Modulating NF-κB and MAPK Pathways

(2015) Zhongbing Liu et al.   INFLAMMATION

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro

(2015) Maurício Guilherme Valente Maturana et al.   NEUROTOXICOLOGY

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson’s disease

(2015) Jiaojiao Qin et al.   TOXICOLOGY LETTERS

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Bioenergetic adaptation in response to autophagy regulators during rotenone exposure

(2014) Samantha Giordano et al.   JOURNAL OF NEUROCHEMISTRY

Involvement of ERK1/2 pathway in neuroprotective effects of pyrroloquinoline quinine against rotenone-induced SH-SY5Y cell injury

(2014) Q. Zhang et al.   NEUROSCIENCE

Rotenone induces neuronal death by microglial phagocytosis of neurons

(2013) Julius V. Emmrich et al.   FEBS Journal

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Pyrroloquinoline Quinine Protects Rat Brain Cortex Against Acute Glutamate-Induced Neurotoxicity

(2013) Qi Zhang et al.   NEUROCHEMICAL RESEARCH

Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway

(2013) Feng Gao et al.   PLoS One

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Autophagy and IL-1 Family Cytokines

(2013) James Harris   Frontiers in Immunology

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats

(2012) Tsu-Kung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

(2012) Chinatsu Otomo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation and Function of Autophagy during Cell Survival and Cell Death

(2012) G. Das et al.   Cold Spring Harbor Perspectives in Biology

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Autophagy in health and disease. 5. Mitophagy as a way of life

(2010) Roberta A. Gottlieb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression

(2009) Winyoo Chowanadisai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY