Is the mitochondrion a promising drug target in trypanosomatids?

Novel N,N-di-alkylnaphthoimidazolium derivative of β-lapachone impaired Trypanosoma cruzi mitochondrial electron transport system

(2021) Ana Cristina S. Bombaça et al.   BIOMEDICINE & PHARMACOTHERAPY

Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity

(2021) Anuj Tripathi et al.   mBio

Evolution of mitochondrial protein import – lessons from trypanosomes

(2020) André Schneider   BIOLOGICAL CHEMISTRY

Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator

(2020) Minu Chaudhuri et al.   Biomolecules

Naphthoquinones and Derivatives for Chemotherapy: Perspectives and Limitations of their Anti-trypanosomatids Activities

(2020) Luíza Dantas-Pereira et al.   CURRENT PHARMACEUTICAL DESIGN

The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module

(2019) Claudia Eichenberger et al.   MOLECULAR MICROBIOLOGY

Failure is not an option – mitochondrial genome segregation in trypanosomes

(2018) André Schneider et al.   JOURNAL OF CELL SCIENCE

The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import

(2018) Iosif Kaurov et al.   CURRENT BIOLOGY

Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles

(2018) Ana Cristina S. Bombaça et al.   FREE RADICAL BIOLOGY AND MEDICINE

Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages

(2017) Yoshinori Fukasawa et al.   MOLECULAR BIOLOGY AND EVOLUTION

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Mitochondrial protein import in trypanosomes: Expect the unexpected

(2017) Anke Harsman et al.   TRAFFIC

Charting organellar importomes by quantitative mass spectrometry

(2017) Christian D. Peikert et al.   Nature Communications

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei

(2017) Sandro Käser et al.   PLoS Pathogens

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

(2017) Alena Zíková et al.   PLoS Pathogens

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase

(2017) Christoph Wenger et al.   PLoS Pathogens

Thiol redox biology of trypanosomatids and potential targets for chemotherapy

(2016) Alejandro E. Leroux et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TbLOK1/ATOM19 is a novel subunit of the noncanonical mitochondrial outer membrane protein translocase ofTrypanosoma brucei

(2016) Silvia Desy et al.   MOLECULAR MICROBIOLOGY

The trypanosome alternative oxidase: a potential drug target?

(2016) STEFANIE K. MENZIES et al.   PARASITOLOGY

Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria

(2016) Sandro Käser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Ubiquinone

(2016) Ying Wang et al.   TRENDS IN CELL BIOLOGY

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

(2016) Anke Harsman et al.   Nature Communications

Tim62, a Novel Mitochondrial Protein inTrypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex

(2015) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances

(2015) Jan Mani et al.   Nature Communications

Induction of Mitochondrial Dysfunction and Oxidative Stress in Leishmania donovani by Orally Active Clerodane Diterpene

(2014) Manoj Kathuria et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids

(2013) Bruno Manta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Mitochondrial shape and function in trypanosomes requires the outer membrane protein, TbLOK1

(2013) Megan L. Povelones et al.   MOLECULAR MICROBIOLOGY

Redox Metabolism in Mitochondria of Trypanosomatids

(2012) Ana M. Tomás et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries

(2012) Elisabeth Eckers et al.   BIOLOGICAL CHEMISTRY

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists

(2012) Somsuvro Basu et al.   EUKARYOTIC CELL

Divergent Molecular Evolution of the Mitochondrial Sulfhydryl:CytochromecOxidoreductase Erv in Opisthokonts and Parasitic Protists

(2012) Elisabeth Eckers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Translocase of Mitochondrial Inner Membrane inTrypanosoma brucei

(2012) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50 inTrypanosoma bruceiPossesses a Dual Specificity Phosphatase Activity and Is Critical for Mitochondrial Protein Import

(2012) Melanie R. Duncan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase

(2012) Anke Harsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Outer Membrane Proteome ofTrypanosoma bruceiReveals Novel Factors Required to Maintain Mitochondrial Morphology

(2012) Moritz Niemann et al.   MOLECULAR & CELLULAR PROTEOMICS

An essential novel component of the noncanonical mitochondrial outer membrane protein import system of trypanosomatids

(2012) Mascha Pusnik et al.   MOLECULAR BIOLOGY OF THE CELL

Comparative SILAC Proteomic Analysis of Trypanosoma brucei Bloodstream and Procyclic Lifecycle Stages

(2012) Michael D. Urbaniak et al.   PLoS One

Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin

(2011) Mascha Pusnik et al.   CURRENT BIOLOGY

In vivo study in Trypanosoma brucei links mitochondrial transfer RNA import to mitochondrial protein import

(2011) Florence Tschopp et al.   EMBO REPORTS

A comparative assessment of mitochondrial function in epimastigotes and bloodstream trypomastigotes of Trypanosoma cruzi

(2011) Renata L. S. Gonçalves et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease

(2011) Carlos Genes et al.   Parasites & Vectors

Mitochondria and Trypanosomatids: Targets and Drugs

(2011) Lianet Monzote Fidalgo et al.   PHARMACEUTICAL RESEARCH

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis

(2010) L. Carvalho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trypanosomatid Parasites Causing Neglected Diseases

(2010) K. Nussbaum et al.   CURRENT MEDICINAL CHEMISTRY

New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

(2010) J. Román Luque-Ortega et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei

(2010) Shvetank Sharma et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Identification, cloning and characterization of an aldo-keto reductase from Trypanosoma cruzi with quinone oxido-reductase activity

(2010) Patricia A. Garavaglia et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction

(2009) Rubem F.S. Menna-Barreto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida)

(2009) Wanderley de Souza et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates with compromised mitochondrial complex I subunit genes

(2009) Julio César Carranza et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Chemical Validation of Trypanothione Synthetase

(2009) Leah S. Torrie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

(2008) R. Luise Krauth-Siegel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Distinctive biochemistry in the trypanosome mitochondrial intermembrane space suggests a model for stepwise evolution of the MIA pathway for import of cysteine-rich proteins

(2008) James W.A. Allen et al.   FEBS LETTERS

Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei

(2008) Ujjal K. Singha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Complex I of Trypanosomatidae: does it exist?

(2008) Fred R. Opperdoes et al.   TRENDS IN PARASITOLOGY