Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity

Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features

(2021) Paul A.M. Michels et al.   EXPERIMENTAL PARASITOLOGY

Biogenesis pathways of α-helical mitochondrial outer membrane proteins

(2020) Layla Drwesh et al.   BIOLOGICAL CHEMISTRY

A Leap Into the Unknown – Early Events in African Trypanosome Transmission

(2020) Balázs Szöőr et al.   TRENDS IN PARASITOLOGY

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei

(2020) Mathieu Cayla et al.   eLife

Evolving Differentiation in African Trypanosomes

(2020) Juan F. Quintana et al.   TRENDS IN PARASITOLOGY

Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator

(2020) Minu Chaudhuri et al.   Biomolecules

Kinetoplast Division Factors in a Trypanosome

(2019) Kojo Mensa-Wilmot et al.   TRENDS IN PARASITOLOGY

Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation

(2019) Balázs Szöőr et al.   mBio

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

(2019) Natalie M. Niemi et al.   Nature Communications

Cardiolipin depletion–induced changes in the Trypanosoma brucei proteome

(2019) David Schädeli et al.   FASEB JOURNAL

The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei

(2019) Anuj Tripathi et al.   mSphere

TbLpn, a key enzyme in lipid droplet formation and phospholipid metabolism, is essential for mitochondrial integrity and growth of Trypanosoma brucei

(2018) Ladan Dawoody Nejad et al.   MOLECULAR MICROBIOLOGY

Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

(2018) Joseph T. Smith et al.   mSphere

The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease

(2018) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Failure is not an option – mitochondrial genome segregation in trypanosomes

(2018) André Schneider et al.   JOURNAL OF CELL SCIENCE

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

(2018) Federico Rojas et al.   CELL

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Mitochondrial protein import in trypanosomes: Expect the unexpected

(2017) Anke Harsman et al.   TRAFFIC

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase

(2017) Christoph Wenger et al.   PLoS Pathogens

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50

(2017) Ketan Malhotra et al.   Science Advances

Loss of protein association causes cardiolipin degradation in Barth syndrome

(2016) Yang Xu et al.   Nature Chemical Biology

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

(2016) Anke Harsman et al.   Nature Communications

The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei

(2016) Manuel Saldivia et al.   Cell Reports

Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma brucei

(2016) Mario Dejung et al.   PLoS Pathogens

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei

(2016) Monica R. Mugnier et al.   PLoS Pathogens

MyxococcusCsgA,DrosophilaSniffer, and human HSD10 are cardiolipin phospholipases

(2015) Tye O'Hara Boynton et al.   GENES & DEVELOPMENT

Tim62, a Novel Mitochondrial Protein inTrypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex

(2015) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress

(2015) Marjorie Fullerton et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1

(2014) Reddy R. Harikrishna et al.   BMB Reports

The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream formTrypanosoma brucei

(2014) Alison C. Lilley et al.   MOLECULAR MICROBIOLOGY

The bacterial-like HslVU protease complex subunits are involved in the control of different cell cycle events in trypanosomatids

(2013) Diane-Ethna Mbang-Benet et al.   ACTA TROPICA

Identification of a novel lipin homologue from the parasitic protozoan Trypanosoma brucei

(2013) Michel Pelletier et al.   BMC MICROBIOLOGY

Structural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) fromTrypanosoma brucei

(2013) Kwang Hoon Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Cell Division Cycle in Trypanosoma brucei

(2012) Ziyin Li   EUKARYOTIC CELL

Human HAD phosphatases: structure, mechanism, and roles in health and disease

(2012) Annegrit Seifried et al.   FEBS Journal

Protein Translocase of Mitochondrial Inner Membrane inTrypanosoma brucei

(2012) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50 inTrypanosoma bruceiPossesses a Dual Specificity Phosphatase Activity and Is Critical for Mitochondrial Protein Import

(2012) Melanie R. Duncan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An essential bacterial-type cardiolipin synthase mediates cardiolipin formation in a eukaryote

(2012) M. Serricchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

(2011) Xinguo Qian et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis

(2011) J. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4

(2010) Christof Osman et al.   EMBO JOURNAL

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway

(2010) B. Szoor et al.   GENES & DEVELOPMENT

The Kinetoplast Duplication Cycle in Trypanosoma brucei Is Orchestrated by Cytoskeleton-Mediated Cell Morphogenesis

(2010) E. Gluenz et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A spectrum of disease in Human African trypanosomiasis: the host and parasite genetics of virulence

(2010) JEREMY M. STERNBERG et al.   PARASITOLOGY

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Trypanosomes Have Six Mitochondrial DNA Helicases with One Controlling Kinetoplast Maxicircle Replication

(2009) Beiyu Liu et al.   MOLECULAR CELL

Identification of a Bacterial-Like HslVU Protease in the Mitochondria of Trypanosoma brucei and Its Role in Mitochondrial DNA Replication

(2008) Ziyin Li et al.   PLoS Pathogens