Functional nanomaterials in peripheral nerve regeneration: Scaffold design, chemical principles and microenvironmental remodeling

Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?

(2021) Holly Gregory et al.   NEUROCHEMISTRY INTERNATIONAL

Boron nitride nanosheets functionalized channel scaffold favors microenvironment rebalance cocktail therapy for piezocatalytic neuronal repair

(2021) Yun Qian et al.   Nano Energy

The Role of Dietary Nutrients in Peripheral Nerve Regeneration

(2021) Marwa El Soury et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomimicry in 3D printing design: implications for peripheral nerve regeneration

(2021) Zhiwen Yan et al.   Regenerative Medicine

Natural Biomaterials as Instructive Engineered Microenvironments That Direct Cellular Function in Peripheral Nerve Tissue Engineering

(2021) Rebecca Powell et al.   Frontiers in Bioengineering and Biotechnology

The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration

(2021) Xiangyun Yao et al.   Regenerative Biomaterials

Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation

(2021) Anamika Singh et al.   Bioactive Materials

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

(2021) Yun Qian et al.   npj Regenerative Medicine

Surface-Anchored Graphene Oxide Nanosheets on Cell-Scale Micropatterned Poly(d,l-lactide-co-caprolactone) Conduits Promote Peripheral Nerve Regeneration

(2020) Deteng Zhang et al.   ACS Applied Materials & Interfaces

Near-Infrared Voltage Nanosensors Enable Real-Time Imaging of Neuronal Activities in Mice and Zebrafish

(2020) Jianan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Graphene Promotes Axon Elongation through Local Stall of Nerve Growth Factor Signaling Endosomes

(2020) Domenica Convertino et al.   NANO LETTERS

Growth and elongation of axons through mechanical tension mediated by fluorescent-magnetic bifunctional Fe3O4·Rhodamine 6G@PDA superparticles

(2020) Yang Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

A highly sensitive and selective nanosensor for near-infrared potassium imaging

(2020) Jianan Liu et al.   Science Advances

Bioinspired Multichannel Nerve Guidance Conduit Based on Shape Memory Nanofibers for Potential Application in Peripheral Nerve Repair

(2020) Jing Wang et al.   ACS Nano

Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe 3 O 4 Magnetic Nanoparticles for Peripheral Nerve Regeneration

(2020) Xuan Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Enhanced integrin affinity and neural differentiation of induced pluripotent stem cells using Ln5-P4-grafted amphiphilic solid lipid nanoparticles

(2020) Yung-Chih Kuo et al.   Materials Science & Engineering C-Materials for Biological Applications

Mechano‐Informed Biomimetic Polymer Scaffolds by Incorporating Self‐Powered Zinc Oxide Nanogenerators Enhance Motor Recovery and Neural Function

(2020) Yun Qian et al.   Small

3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration

(2020) Zhongyang Zhang et al.   BIOMATERIALS

Application of electrospun polycaprolactone fibers embedding lignin nanoparticle for peripheral nerve regeneration: In vitro and in vivo study

(2020) Shahram Amini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Supramolecular Induction of Mitochondrial Aggregation and Fusion

(2020) Chen Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A glycolytic shift in Schwann cells supports injured axons

(2020) Elisabetta Babetto et al.   NATURE NEUROSCIENCE

Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly

(2020) Bojing Jiang et al.   Science Advances

Preparation and characterization of self-electrical stimuli conductive gellan based nano scaffold for nerve regeneration containing chopped short spun nanofibers of PVDF/MCM41 and polyaniline/graphene nanoparticles: Physical, mechanical and morphological studies

(2020) Mojdeh Mohseni et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

(2020) Yeon Sik Choi et al.   Nature Communications

A fully biodegradable and self-electrified device for neuroregenerative medicine

(2020) Liu Wang et al.   Science Advances

Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering

(2020) Zhong Huang et al.   Cells

Preparation of Graphene Oxide-Doped Polypyrrole Composite Films with Stable Conductivity and Their Effect on the Elongation and Alignment of Neurite

(2019) Lei Shang et al.   ACS Biomaterials-Science & Engineering

Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge

(2019) Xin-peng Dun et al.   Cell Reports

Aligned Brain Extracellular Matrix Promotes Differentiation and Myelination of Human-Induced Pluripotent Stem Cell-Derived Oligodendrocytes

(2019) Ann-Na Cho et al.   ACS Applied Materials & Interfaces

Scalable Fabrication of Porous Microchannel Nerve Guidance Scaffolds with Complex Geometries

(2019) Dena Shahriari et al.   ADVANCED MATERIALS

Biodelivery of nerve growth factor and gold nanoparticles encapsulated in chitosan nanoparticles for schwann-like cells differentiation of human adipose-derived stem cells

(2019) Shahnaz Razavi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased ER–mitochondria tethering promotes axon regeneration

(2019) Soyeon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: involvement of growth factors and integrin-linked kinase

(2019) Elahe Karimi et al.   Drug Design Development and Therapy

Multilayered spraying and gradient dotting of nanodiamond–polycaprolactone guidance channels for restoration of immune homeostasis

(2019) Yun Qian et al.   NPG Asia Materials

Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves

(2019) Yi Zhang et al.   Science Advances

Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells

(2019) Yuka Matsuzaki et al.   Biomolecules

Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response

(2019) Jeong In Kim et al.   ADVANCED FUNCTIONAL MATERIALS

(‐)‐Epigallocatechin gallate‐loaded polycaprolactone scaffolds fabricated using a 3D integrated moulding method alleviate immune stress and induce neurogenesis

(2019) Yun Qian et al.   CELL PROLIFERATION

Advances in electrical and magnetic stimulation on nerve regeneration

(2019) Yun Qian et al.   Regenerative Medicine

In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

(2019) Meifeng Zhu et al.   Nature Communications

Functional Nanomaterial for Theranostic Medicine

(2019) Pengfei Zhang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Concentrically Integrative Bioassembly of a Three-Dimensional Black Phosphorus Nanoscaffold for Restoring Neurogenesis, Angiogenesis, and Immune Homeostasis

(2019) Yun Qian et al.   NANO LETTERS

Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge

(2019) Bing Chen et al.   Frontiers in Molecular Neuroscience

3D Manufacture of Gold Nanocomposite Channels Facilitates Neural Differentiation and Regeneration

(2018) Yun Qian et al.   ADVANCED FUNCTIONAL MATERIALS

Temporal changes in macrophage phenotype after peripheral nerve injury

(2018) Joy E. Tomlinson et al.   Journal of Neuroinflammation

3D melatonin nerve scaffold reduces oxidative stress, inflammation and increases autophagy in peripheral nerve regeneration

(2018) Yun Qian et al.   JOURNAL OF PINEAL RESEARCH

Gold nanorod-assisted near-infrared stimulation of bullfrog sciatic nerve

(2018) Zongxia Mou et al.   LASERS IN MEDICAL SCIENCE

Nano-fibrous and ladder-like multi-channel nerve conduits: Degradation and modification by gelatin

(2018) Sheng Liu et al.   Materials Science & Engineering C-Materials for Biological Applications

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain

(2018) SeungHwan Lee et al.   Molecular Pain

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

Intrinsic mechanisms of neuronal axon regeneration

(2018) Marcus Mahar et al.   NATURE REVIEWS NEUROSCIENCE

Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury

(2018) Wenjing Lv et al.   NEUROSCIENCE

State-of-the-Art Techniques in Treating Peripheral Nerve Injury

(2018) Carrie A. Kubiak et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration

(2018) Yun Qian et al.   Nature Communications

Spectrally distinct channelrhodopsins for two-colour optogenetic peripheral nerve stimulation

(2018) Benjamin E. Maimon et al.   Nature Biomedical Engineering

Polymeric nanoparticles decorated with BDNF-derived peptide for neuron-targeted delivery of PTEN inhibitor

(2018) Jing Xu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mitochondrial behavior during axon regeneration/degeneration in vivo

(2018) Sumiko Kiryu-Seo et al.   NEUROSCIENCE RESEARCH

Injectable, Magnetically Orienting Electrospun Fiber Conduits for Neuron Guidance

(2018) Christopher D. L. Johnson et al.   ACS Applied Materials & Interfaces

Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity

(2018) Joao L. Carvalho-de-Souza et al.   ACS Chemical Neuroscience

Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes

(2018) Yachao Jia et al.   Acta Biomaterialia

Vascularized 3D printed scaffolds for promoting bone regeneration

(2018) Yufei Yan et al.   BIOMATERIALS

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

(2018) Jahyun Koo et al.   NATURE MEDICINE

π-Conjugated polyaniline-assisted flexible titania nanotubes with controlled surface morphology as regenerative medicine in nerve cell growth

(2018) Bishnu Kumar Shrestha et al.   CHEMICAL ENGINEERING JOURNAL

Rearrangement of potassium ions and Kv1.1/Kv1.2 potassium channels in regenerating axons following end-to-end neurorrhaphy: ionic images from TOF-SIMS

(2017) Chiung-Hui Liu et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient

(2017) Se Heang Oh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Heparin/collagen encapsulating nerve growth factor multilayers coated aligned PLLA nanofibrous scaffolds for nerve tissue engineering

(2017) Kuihua Zhang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Sciatic nerve regeneration by transplantation of Schwann cells via erythropoietin controlled-releasing polylactic acid/multiwalled carbon nanotubes/gelatin nanofibrils neural guidance conduit

(2017) Majid Salehi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Tailored release of triiodothyronine and retinoic acid from a spatio-temporally fabricated nanofiber composite instigating neuronal differentiation

(2017) Aishwarya Satish et al.   Nanoscale

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

(2017) Chloé Dominici et al.   NATURE

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

(2017) Melanie P. Clements et al.   NEURON

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

(2017) Yi-Lan Weng et al.   NEURON

Neuroregeneration of Induced Pluripotent Stem Cells in Polyacrylamide-Chitosan Inverted Colloidal Crystal Scaffolds with Poly(lactide-co-glycolide) Nanoparticles and Transactivator of Transcription von Hippel-Lindau Peptide

(2017) Yung-Chih Kuo et al.   TISSUE ENGINEERING PART A

Magnetic Nanoparticles for Efficient Delivery of Growth Factors: Stimulation of Peripheral Nerve Regeneration

(2017) Martina Giannaccini et al.   Advanced Healthcare Materials

Micro-Nanostructured Polyaniline Assembled in Cellulose Matrix via Interfacial Polymerization for Applications in Nerve Regeneration

(2016) Dingfeng Xu et al.   ACS Applied Materials & Interfaces

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria on the Road to Power Axonal Regeneration

(2016) Lilian A. Patrón et al.   NEURON

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration

(2016) Romain Cartoni et al.   NEURON

The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS

(2016) Andrea Tedeschi et al.   NEURON

Mitochondria Localize to Injured Axons to Support Regeneration

(2016) Sung Min Han et al.   NEURON

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

(2016) Yan Hao et al.   eLife

Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

(2016) Margarita Calvo et al.   eLife

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

(2015) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves

(2015) Anne-Laure Cattin et al.   CELL

Filamin A Is Required in Injured Axons for HDAC5 Activity and Axon Regeneration

(2015) Yongcheol Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing Peripheral Nerve Regeneration by Whole Mount Staining

(2015) Xin-peng Dun et al.   PLoS One

Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization

(2014) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

Sir Herbert Seddon (1903–1977) and his classification scheme for peripheral nerve injury

(2014) Yasemin Kaya et al.   CHILDS NERVOUS SYSTEM

Nano-Biomimetics for Nano/Micro Tissue Regeneration

(2014) Dolly Singh et al.   Journal of Biomedical Nanotechnology

Schwann Cells and Deleted in Colorectal Carcinoma Direct Regenerating Motor Axons Towards Their Original Path

(2014) A. F. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

3D nano/microfabrication techniques and nanobiomaterials for neural tissue regeneration

(2014) Wei Zhu et al.   Nanomedicine

Historical vignette of Cajal's work “Degeneration and regeneration of the nervous system” with a reflection of the author

(2014) R.D. Lobato   NEUROCIRUGIA

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair

(2013) Timothy L. Scott et al.   ANTIOXIDANTS & REDOX SIGNALING

Intracellular reactive oxidative stress, cell proliferation and apoptosis of Schwann cells on carbon nanofibrous substrates

(2013) Shilpee Jain et al.   BIOMATERIALS

Chondroitin sulphate-based 3D scaffolds containing MWCNTs for nervous tissue repair

(2013) María C. Serrano et al.   BIOMATERIALS

Laser exposure of gold nanorods can increase neuronal cell outgrowth

(2013) Chiara Paviolo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration

(2013) Yongcheol Cho et al.   CELL

Local translation in neuronal processes-in vivotests of a “heretical hypothesis”

(2013) Rotem B. Perry et al.   Developmental Neurobiology

Laser exposure of gold nanorods can induce intracellular calcium transients

(2013) Chiara Paviolo et al.   Journal of Biophotonics

Peripheral Nerve Repair and Reconstruction

(2013) Justin W. Griffin et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Gold nanoparticles functionalized with a fragment of the neural cell adhesion molecule L1 stimulate L1-mediated functions

(2013) Florian Schulz et al.   Nanoscale

Advances in peripheral nerve regeneration

(2013) Jami Scheib et al.   Nature Reviews Neurology

Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury

(2013) Linxia Zhang et al.   NEUROBIOLOGY OF DISEASE

Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain

(2013) Jizhe Hao et al.   NEURON

Axonal transcription factors signal retrogradely in lesioned peripheral nerve

(2012) Keren Ben-Yaakov et al.   EMBO JOURNAL

Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

(2012) Ya Zhang et al.   International Journal of Nanomedicine

Drebrin controls neuronal migration through the formation and alignment of the leading process

(2012) Xin-peng Dun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

(2012) Frank Bradke et al.   NATURE REVIEWS NEUROSCIENCE

Specificity of peripheral nerve regeneration: Interactions at the axon level

(2012) Ilary Allodi et al.   PROGRESS IN NEUROBIOLOGY

Effect of Surface Pore Structure of Nerve Guide Conduit on Peripheral Nerve Regeneration

(2012) Se Heang Oh et al.   TISSUE ENGINEERING PART C-METHODS

Nanospheres Delivering the EGFR TKI AG1478 Promote Optic Nerve Regeneration: The Role of Size for Intraocular Drug Delivery

(2011) Rebecca Robinson et al.   ACS Nano

Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages

(2011) Daniel Baitsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types

(2011) Elly JF Vereyken et al.   Journal of Neuroinflammation

Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth

(2011) M. B. Steketee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

Conducting-Polymer Nanotubes Improve Electrical Properties, Mechanical Adhesion, Neural Attachment, and Neurite Outgrowth of Neural Electrodes

(2010) Mohammad Reza Abidian et al.   Small

Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation

(2010) David P. Stirling et al.   TRENDS IN MOLECULAR MEDICINE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Introduction: Peripheral Nerve Surgery—Biology, Entrapment, and Injuries

(2009) Allan H. Friedman et al.   Neurosurgical Focus