Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair

Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics

(2013) Li Shen et al.   CELL

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mitochondrial Nucleoid: Integrating Mitochondrial DNA into Cellular Homeostasis

(2013) R. Gilkerson et al.   Cold Spring Harbor Perspectives in Biology

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

Mitochondria and Cancer: Past, Present, and Future

(2013) M. L. Verschoor et al.   Biomed Research International

Cytoplasmic Ape1 Expression Elevated by p53 Aberration May Predict Survival and Relapse in Resected Non-Small Cell Lung Cancer

(2012) Heng-Hsiung Wu et al.   ANNALS OF SURGICAL ONCOLOGY

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

(2012) Sanjib Dey et al.   DNA REPAIR

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

(2012) Attila Bacsi et al.   DNA REPAIR

Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine

(2012) Istvan Boldogh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Evolutionary View of the Mechanism for Immune and Genome Diversity

(2012) L. Kato et al.   JOURNAL OF IMMUNOLOGY

A Protein Array Screen for Kaposi's Sarcoma-Associated Herpesvirus LANA Interactors Links LANA to TIP60, PP2A Activity, and Telomere Shortening

(2012) M. Shamay et al.   JOURNAL OF VIROLOGY

Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis

(2012) Wu Wei et al.   MOLECULAR BIOLOGY REPORTS

Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

(2012) Shizue Ohsawa et al.   NATURE

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

A high-throughput approach for measuring temporal changes in the interactome

(2012) Anders R Kristensen et al.   NATURE METHODS

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Assessment of Cr(VI)-Induced Cytotoxicity and Genotoxicity Using High Content Analysis

(2012) Chad M. Thompson et al.   PLoS One

Expression and purification of active mouse and human NEIL3 proteins

(2012) Minmin Liu et al.   PROTEIN EXPRESSION AND PURIFICATION

Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer

(2012) Nolan G. Ericson et al.   PLoS Genetics

Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells

(2011) Heini Ruhanen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate

(2011) Melissa M. Grant   BMB Reports

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

(2011) Salvatore Cortellino et al.   CELL

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development

(2011) Azusa Inoue et al.   CELL RESEARCH

Interactions of Pathological Hallmark Proteins

(2011) Judit Oláh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome

(2011) Anne W. Tann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host Cell Interactome of HIV-1 Rev Includes RNA Helicases Involved in Multiple Facets of Virus Production

(2011) Souad Naji et al.   MOLECULAR & CELLULAR PROTEOMICS

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

(2011) Carlo Vascotto et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

(2011) Daniel Cortázar et al.   NATURE

Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5

(2011) Carlos S. Busso et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

(2011) Cornelia Meisenberg et al.   NUCLEIC ACIDS RESEARCH

Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

(2011) Anne Riemann et al.   PLoS One

A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

(2011) A. Vinayagam et al.   Science Signaling

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Posttranslational modification of mammalian AP endonuclease (APE1)

(2010) Carlos S. Busso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functions of disordered regions in mammalian early base excision repair proteins

(2010) Muralidhar L. Hegde et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evidence that OGG1 Glycosylase Protects Neurons against Oxidative DNA Damage and Cell Death under Ischemic Conditions

(2010) Dong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells

(2010) Ok-Hee Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

(2010) Jannie M. R. Danielsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-κB activation

(2010) H-H Wu et al.   ONCOGENE

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

(2010) S Sengupta et al.   ONCOGENE

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

(2010) X. V. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway

(2010) P. Hajkova et al.   SCIENCE

Quantitative Nanoproteomics for Protein Complexes (QNanoPX) Related to Estrogen Transcriptional Action

(2009) Pai-Chiao Cheng et al.   MOLECULAR & CELLULAR PROTEOMICS

Complementary Quantitative Proteomics Reveals that Transcription Factor AP-4 Mediates E-box-dependent Complex Formation for Transcriptional Repression ofHDM2

(2009) Wei-Chi Ku et al.   MOLECULAR & CELLULAR PROTEOMICS

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

(2009) James E. Cleaver et al.   NATURE REVIEWS GENETICS

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

(2009) T. Barnes et al.   NUCLEIC ACIDS RESEARCH

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

(2009) P. Burkovics et al.   NUCLEIC ACIDS RESEARCH

Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase

(2009) Ryan D. Mohan et al.   NUCLEIC ACIDS RESEARCH

OGG1 is a novel prognostic indicator in acute myeloid leukaemia

(2009) K Liddiard et al.   ONCOGENE

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53–MDM2 signaling pathway

(2009) C S Busso et al.   ONCOGENE

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

(2008) Mansour Akbari et al.   DNA REPAIR

Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

(2008) Bartosz Szczesny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinating the Initial Steps of Base Excision Repair

(2008) Megan E. Fitzgerald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Analysis of global Ubiquitination in HeLa Cells by Mass Spectrometry

(2008) David Meierhofer et al.   JOURNAL OF PROTEOME RESEARCH

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

(2008) M.M. Georgiadis et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

Alteration of APE1/ref-1 expression in non-small cell lung cancer: The implications of impaired extracellular superoxide dismutase and catalase antioxidant systems

(2007) Dae Goon Yoo et al.   LUNG CANCER

TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: A novel pathway in B cell activation

(2007) Sonia Merluzzi et al.   MOLECULAR IMMUNOLOGY