Article
Emergency Medicine
Taotao Hu, Shusen Chang, Fang Qi, Zhonghui Zhang, Jiayin Chen, Lingli Jiang, Dali Wang, Chengliang Deng, Kaiyu Nie, Guangchao Xu, Zairong Wei
Summary: This study investigated the role of exosomes derived from Schwann cell-like cells (SCLCs) in peripheral nerve regeneration. SCLCs-exo significantly enhanced motor function recovery, attenuated muscle atrophy, and facilitated axonal regrowth, myelin formation, and angiogenesis. Furthermore, SCLCs-exo efficiently promoted proliferation and migration of Schwann cells and upregulated the expression of neurotrophic factors, myelin regulators, and myelin proteins.
Article
Cell & Tissue Engineering
Stefania Brambilla, Martino Guiotto, Enrica Torretta, Ilaria Armenia, Matteo Moretti, Cecilia Gelfi, Silvia Palombella, Pietro G. di Summa
Summary: Trauma-associated peripheral nerve injury is a common problem that contributes to sensory and motor disabilities. Schwann cells and adipose-derived stem cells (ASCs) can promote nerve regeneration, mainly by secreting neurotrophic factors. This study compared the neurotrophic properties of differentiated SC-like ASCs and HPL-cultured ASCs, and found that HPL-ASCs exhibited higher neurotrophic abilities.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Shuhai Chen, Tetsuya Ikemoto, Takuya Tokunaga, Shouhei Okikawa, Katsuki Miyazaki, Shinichiro Yamada, Yu Saito, Yuji Morine, Mitsuo Shimada
Summary: This study successfully generated 3D SLC spheroids with improved functionality by modifying the differentiation protocol of ADSCs. The results demonstrated that these 3D SLC spheroids could more effectively promote nerve regeneration and have great potential for clinical treatment.
CELL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Luca Scaccini, Roberta Mezzena, Alessia De Masi, Mariacristina Gagliardi, Giovanna Gambarotta, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method using chitosan scaffolds to promote nerve regeneration, showing that asymmetric directional topographies can enhance cell proliferation and migration speed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Zilong Rao, Zudong Lin, Panpan Song, Daping Quan, Ying Bai
Summary: Schwann cells (SCs) transplantation is a feasible method for promoting nerve injury repair, but direct cell transplantation has limited efficacy. Biomaterials as carriers can enhance cell transplantation efficacy, and introducing complex extracellular matrix (ECM) factors and components can promote nerve regeneration. Cell-free transplantation approaches also have the potential for clinical applications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell & Tissue Engineering
Qunzhou Zhang, Justin C. Burrell, Jincheng Zeng, Faizan Motiwala, Shihong Shi, D. Kacy Cullen, Anh D. Le
Summary: This study generated gingiva-derived mesenchymal stem cell (GMSC)-repopulated nerve protectors and evaluated their therapeutic effects in a crush injury model. The results showed that the Schwann-like cells converted from GMSCs were able to promote functional recovery and axonal regeneration of injured sciatic nerves.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jaafar Faez Kadhim Alsadooni, Mehdi Haghi, Abolfazl Barzegar, Mohammad Ali Hosseinpour Feizi
Summary: Colon cancer is a major global health issue, and chemotherapy, its primary treatment, has limitations due to toxicity and drug resistance. Researchers have explored alternative therapeutic approaches, such as using chitosan and paclitaxel. This study investigated the effectiveness of a chitosan hydrogel loaded with a complex of gold nanoparticles and paclitaxel in treating colon cancer cells, showing promising cytotoxic and pro-apoptotic effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Physiology
Zairong Wei, Shenyou Shu, Mingjun Zhang, Sitian Xie, Shijie Tang, Kaiyu Nie, Haihong Li
Summary: Single-cell RNA sequencing of hAMSCs and SCLCs revealed a subpopulation of SCLCs highly expressing nerve regeneration-related genes and terms associated with inflammation and tissue repair, suggesting they may be the key populations promoting nerve regeneration.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiwen Jiang, Wei Zhang, Chenqi Liu, Lixin Xia, Shuo Wang, Yanting Wang, Kai Shao, Baoqin Han
Summary: This study designed a CM-chitosan-based nerve guidance conduit (NGC) which can promote the reconstruction of damaged peripheral nerves without the addition of other activation factors. CM-chitosan exhibited excellent performance in vitro for nerve tissue engineering and had increased longevity upon cross-linking with 1,4-Butanediol diglycidyl ether. Implantation of the C-CM-chitosan NGCs effectively improved nerve function reconstruction in rats, showing regenerative efficacy similar to that of autograft.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Hilla Pe'er-Nissan, Hadas Ahdoot-Levi, Oshra Betzer, Pnina Shirel Itzhak, Niva Shraga-Heled, Iris Gispan, Menachem Motiei, Arthur Doroshev, Yaakov Anker, Rachela Popovtzer, Racheli Ofir, Gal Yadid
Summary: Recent research suggests that mesenchymal stem cells, especially placenta-derived mesenchymal stromal-like cells (PLX-PAD), have potential in treating neurological disorders, particularly drug addiction. In a rat model for cocaine addiction, the administration of PLX-PAD cells through intracerebroventricular or intranasal routes attenuated cocaine-seeking behavior by migrating to specific mesolimbic regions, homing on the hippocampus, and restoring neurogenesis. The findings suggest that intranasal cell therapy could be a safe and effective approach to treating addiction and may provide a novel and efficient method for rehabilitation.
Article
Medicine, Research & Experimental
Wei Chen, Shusen Chang, Chenglan Yang, Jian Zhou, Huizhong Zhang, Kaiyu Nie, Zairong Wei
Summary: This study investigated the mechanism underlying sensory function reconstruction using Schwann cells (SCs). The researchers found that the SOX2/FN1 axis and exosomes secreted by SCs promoted nerve regeneration and recovery.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Ziying Zhu, Yujun Zhang, Zhihua Huang, Haojie Hao, Muyang Yan
Summary: We found that small extracellular vesicles (sEVs) produced from umbilical cord mesenchymal stem cells (MSC-sEVs) cultured under hypoxia can promote repair and regeneration of peripheral nerve injury (PNI). These findings suggest that MSC-sEVs may be a promising therapeutic drug candidate for PNI treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Min You, Haizhu Xing, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is a neurological disorder caused by paclitaxel (PTX) treatment in cancer patients. Schwann cell-derived exosomes (SC-EXOs) have been found to effectively improve PIPN both in vitro and in vivo. SC-EXOs alleviate PTX-induced mechanical nociceptive sensitization, ameliorate nerve fiber loss and DRG injury, and protect damaged neurons by upregulating miR-21 to repress the PTEN signaling pathway. These findings provide a novel strategy for the treatment of PIPN.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sailing Chen, Qianqian Chen, Xiaojiao Zhang, Yinying Shen, Xinyu Shi, Xiu Dai, Sheng Yi
Summary: Peripheral nerves have limited ability to regenerate after injury. The growth factor amphiregulin (AREG) is upregulated in Schwann cells of injured sciatic nerves and stimulates their proliferation and migration. Schwann cell-secreted AREG promotes neurite outgrowth and axon elongation. Administering AREG to injured nerves facilitates Schwann cell proliferation, cord formation, and axon regrowth. Overall, our study identifies AREG as an important neurotrophic factor and offers a promising therapeutic approach for peripheral nerve injuries.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Jun Sun, Zhi Liao, Zhangyu Li, Hao Li, Zhimin Wu, Chuan Chen, Hui Wang
Summary: This study focused on investigating the roles and mechanisms of exosomes derived from Schwann cells under different conditions in regulating macrophagic sub-phenotypes and peripheral nerve injury repair. The study found that exosomes from normal oxygen condition Schwann cells promoted M2 macrophagic polarization and facilitated axon elongation, while exosomes from post-injury oxygen-glucose-deprivation-condition Schwann cells promoted M1 polarization and inhibited axon elongation. The down-regulation of miR-146a-5p was closely related to the shift of exosomes to pro-inflammatory phenotype. The study concluded that miR-146a-5p played an important role in regulating macrophagic phenotype and had implications for axonal regeneration and functional recovery.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Reihaneh Seyedebrahimi, Shahnaz Razavi, Jaleh Varshosaz
JOURNAL OF CLUSTER SCIENCE
(2020)
Review
Cell & Tissue Engineering
Maliheh Jahromi, Shahnaz Razavi, Abbas Bakhtiari
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Endocrinology & Metabolism
Zeinab Shakerin, Ebrahim Esfandiari, Mustafa Ghanadian, Shahnaz Razavi, Hojjatallah Alaei, Gholamreza Dashti
METABOLIC BRAIN DISEASE
(2020)
Article
Reproductive Biology
Farnaz Khadivi, Shahnaz Razavi, Fatemeh Hashemi
Article
Oncology
Shahnaz Razavi, Fatemeh Hashemi, Farnaz Khadivi, Abbas Bakhtiari, Amir Mokhtarian, Hamed Mirzaei
Summary: The study investigated the effects of omega 3 treatment on sperm chromatin condensation, DNA damage, and spermatogenesis following BEP treatment in rats. Results showed that omega 3 significantly reduced excessive histone and DNA damage in sperm, and also influenced the number of spermatogonia, primary spermatocytes, leydig cells, and testicular histology properties after BEP treatment. Omega 3 may have a beneficial effect on improving chromatin condensation, DNA damage, and testicular histomorphic properties following BEP treatment.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Reihaneh Seyedebrahimi, Shahnaz Razavi, Jaleh Varshosaz, Elham Vatankhah, Mohammad Kazemi
Summary: This study suggests a potential method for inducing the differentiation of h-ADSCs into SCs by tuning the surface of aligned poly (lactic-co-glycolic acid) (PLGA) nanofibers to enhance attachment and proliferation of h-ADSCs on the scaffold. Additionally, the presence of BDNF and AuNPs on scaffold significantly improved the expression of SC markers compared to the control group.
JOURNAL OF CLUSTER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shahram Amini, Ahmad Saudi, Noushin Amirpour, Maliheh Jahromi, Samira Shariati Najafabadi, Mohammad Kazemi, Mohammad Rafienia, Hossein Salehi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Maliheh Jahromi, Shahnaz Razavi, Reihaneh Seyedebrahimi, Parham Reisi, Mohammad Kazemi
Summary: The combination of AuNPs and BDNF encapsulated in chitosan nanoparticles implanted in NGC, along with r-ADSCs, synergistically promotes nerve regeneration, showing potential as a new strategy for peripheral nerve regeneration.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Shahnaz Razavi, Maliheh Jahromi, Elham Vatankhah, Reihaneh Seyedebrahimi
Summary: The study investigated how the inner surface of electrospun PLGA nanofibrous conduit could be biofunctionalized with laminin containing BDNF and gold nanoparticles in chitosan nanoparticles. Results demonstrated that the PLGA conduit filled with r-ADSCs, with or without fibrin matrix, significantly improved the sciatic functional index and nerve fiber diameter relative to other implanted groups. Additionally, the combination of fibrin matrix and other factors showed potential beneficial effects on nerve regeneration, suggesting further research is needed to explore their distinctive effects.
Review
Biochemistry & Molecular Biology
Maryam Azimzadeh, Nora Moehn, Sajjad Ghane Ezabadi, Zahra Moghimi Esfandabadi, Alireza Soleimani, Elaheh Ranjbar, Maliheh Jahromi, Reihaneh Seyedebrahimi, Thomas Skripuletz, Farshad Moharrami Kasmaie
Summary: While there were initial speculations that MS patients might be more susceptible to COVID-19, recent data have shown that they do not have a higher risk for severe infection. Although MS patients on immunomodulatory/immunosuppressive therapy are not generally at higher risk for severe COVID-19, the hazards of poorly treated MS may outweigh the putative dangers of COVID-19.
Article
Cell Biology
Shahnaz Razavi, Farnaz Khadivi, Fatemeh Hashemi, Abbas Bakhtiari
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
