Article
Neurosciences
Annelies Van Dyck, Luca Masin, Steven Bergmans, Giel Schevenels, An Beckers, Benoit Vanhollebeke, Lieve Moons
Summary: Unlike mammals, adult zebrafish can fully regenerate axons and recover from neuronal damage in the central nervous system. By studying optic nerve injury-induced axonal regrowth in zebrafish, researchers have observed dendritic remodeling and changes in mitochondrial dynamics, which contribute to effective axonal and dendritic repair. A novel microfluidic model has been developed to investigate these interactions and explore how redirecting energy resources supports successful regeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Julieta Schmidt, Hector Ramiro Quinta
Summary: Traumatic spinal cord injuries cause disruption of axonal projections, resulting in impaired locomotor, sensory, and autonomic functions. Mitochondrial dysfunction in the injured spinal tissue prevents the regeneration of severed axons, leading to sustained impairment in voluntary control of movement. This review discusses the link between mitochondrial dysfunction and axonal regeneration failure in spinal cord injury, and explores potential mitochondria-targeted therapeutic approaches to promote functional recovery.
NEURAL REGENERATION RESEARCH
(2023)
Article
Urban Studies
Zaoxing Yao, Bin Li, Guicai Li, Chunxia Zeng
Summary: This study investigates urban politics under asymmetric power structures in Chinese urban regeneration, revealing a resilient relationship between social demand and governmental response. The research establishes a resilient asymmetric power model to reveal the political nature of governance with more resilience and asymmetric power compared with other power models. The study constructs a research perspective called 'resilient governance under asymmetric power structures' as a bridge between political science and urban governance.
Article
Cell Biology
Vinicius Toledo Ribas, Bjorn Friedhelm Vahsen, Lars Tatenhorst, Veronica Estrada, Vivian Dambeck, Raquel Alves Almeida, Mathias Baehr, Uwe Michel, Jan Christoph Koch, Hans Werner Mueller, Paul Lingor
Summary: Inhibition of ULK1 promotes axonal regeneration and neurite outgrowth, increases neuronal survival, and enhances axonal protection after optic nerve and spinal cord injuries. Additionally, it leads to increased sprouting of serotonergic and dopaminergic axons after spinal cord injury by activating ERK1 and reducing RhoA and ROCK2 expression. ULK1 is identified as a key regulator for axonal degeneration and regeneration, and a promising target for neuroprotection and regeneration in the CNS.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Yu-Jih Su, Pei-Wen Wang, Shao-Wen Weng
Summary: The role of mitochondria in the immune system is crucial, providing energy, activating cells, and playing a key role in tissue regeneration and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marc Hernaiz-Llorens, Ramon Martinez-Marmol, Cristina Rosello-Busquets, Eduardo Soriano
Summary: Central nervous system damage from various causes is a major worldwide contributor to physical disability. The limited ability of the adult nervous system to heal and regenerate after injury has prompted research into therapies to enhance axonal regeneration. Recent findings suggest a link between the stability and composition of lipid rafts and the capacity of axons to rebuild functional neural circuits after damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bohm Lee, Yongcheol Cho
Summary: Neurons in different nervous systems have varying abilities to regenerate, with rodents serving as key models for studying these mechanisms and advancing understanding of human diseases and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Alireza P. Shabanzadeh, Jason Charish, Nardos G. Tassew, Nahal Farhani, Jinzhou Feng, Xinjue Qin, Shuzo Sugita, Andrea J. Mothe, Thomas Walchli, Paulo D. Koeberle, Philippe P. Monnier
Summary: The inhibition of cholesterol synthesis has been shown to promote axonal regeneration and survival, offering a potential therapeutic approach for neuronal regeneration in the central nervous system. Altering the association of cell surface receptors with lipid rafts can neutralize inhibitory functions and provide opportunities for promoting CNS regeneration and survival. Late stage cholesterol synthesis inhibition alters Neogenin association with lipid rafts, thereby offering a novel approach for promoting regeneration and survival following injuries.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Chang Liu, Weina Gao, Long Zhao, Yi Cao
Summary: Progesterone can reduce axonal damage and provide partial neuroprotective effects after intracerebral hemorrhage (ICH) through the PI3K/AKT/mTOR pathway.
Review
Chemistry, Medicinal
Hanne Belien, Lize Evens, Marc Hendrikx, Virginie Bito, Annelies Bronckaers
Summary: Myocardial infarction, the leading cause of heart failure worldwide, has sparked interest in stem cell therapy for cardiac repair. While some successful results have been achieved in animal models, the overall outcome of clinical trials has been disappointing, mainly due to limited stem cell survival and retention. Combinational use of stem cells and various priming strategies may hold promise for improving regenerative cell therapy efficacy.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Plant Sciences
Wei Ying, Guangchao Wen, Wenyuan Xu, Haixia Liu, Wona Ding, Luqing Zheng, Yi He, Huwei Yuan, Daoliang Yan, Fuqiang Cui, Jianqin Huang, Bingsong Zheng, Xiaofei Wang
Summary: Woody plants play a vital role in global ecosystems, but gene function research and biotechnological breeding have lagged behind. Agrobacterium rhizogenes has emerged as a transformative tool in woody plant research, enabling gene function analysis, gene expression profiling, gene interaction studies, and gene regulation analysis. The introduction of the Ri plasmid shows potential for breeding purposes.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Cell Biology
Ana Catarina Costa, Monica Mendes Sousa
Summary: Neurons are polarized cells and the regulation of the microtubule cytoskeleton is crucial for their function. A group of microtubule-severing enzymes, including spastin, have been found to play an important role in regulating microtubule organization and axonal transport.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yao Wang, Zongliang Xiong, Chong Zhou, Qiyuan Zhang, Shuang Liu, Sainan Dong, Xiaowen Jiang, Wenhui Yu
Summary: The study demonstrates that AKBA has a pro-recovery effect on sciatic nerve injury by promoting axon regeneration and improving cellular components of myelin sheath. AKBA regulates the expression of CDC42, Rac1, RhoA, and Rictor, which play important roles in nerve repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Anna Maria Sacco, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Stefano Palermi, Rocco Spera, Rossana Gnasso, Giorgio Zinno, Veronica Romano, Immacolata Belviso
Summary: Cardiac regeneration is crucial for treating heart diseases, focusing on repairing and enhancing damaged myocardium. Stem cell-based therapies using adult and pluripotent stem cells hold immense potential for replenishing lost cardiomyocytes and facilitating cardiac tissue repair. Tissue engineering employs biomaterials to construct cardiac patches and grafts with suitable properties, and bioreactors to create functional constructs for cardiac recovery, aiming to provide mechanical support and promote tissue healing when transplanted into the heart.
APPLIED SCIENCES-BASEL
(2023)
