Article
Neurosciences
Deepak Prasad Gupta, Anup Bhusal, Md Habibur Rahman, Jae-Hong Kim, Youngshik Choe, Jaemyung Jang, Hyun Jin Jung, Un-Kyung Kim, Jin-Sung Park, Lee-so Maeng, Kyoungho Suk, Gyun Jee Song
Summary: This study reveals the essential role of EBP50 in the repair function of Schwann cells and regeneration following nerve injury. EBP50 deficiency leads to deficits in Schwann cell functions and delays nerve repair and functional recovery. Additionally, EBP50 enhances regeneration by binding and activating ErbB2.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi
Summary: Research findings indicate that Btc plays essential roles in regulating Schwann cell migration and axon elongation, suggesting the potential application of Btc as a regenerative strategy for treating peripheral nerve injury.
MOLECULAR MEDICINE
(2021)
Review
Neurosciences
Jenica Acheta, Shannon B. Z. Stephens, Sophie Belin, Yannick Poitelon
Summary: This review discusses the known and possible molecular mechanisms activated in repair Schwann cells in response to low-intensity ultrasound (LIU), drawing support and attention to LIU as a compelling regenerative treatment for peripheral nerve injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Jue Ling, Chang He, Shuxuan Zhang, Yahong Zhao, Meifeng Zhu, Xiaoxuan Tang, Qiaoyuan Li, Liming Xu, Yumin Yang
Summary: This article provides an overview of evaluation methods used to study scaffold-based therapies for peripheral nerve injury (PNI) in experimental animal models, with particular focus on Schwann cell functions and axonal growth within the regenerated nerve.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schaedl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher
Summary: This study reveals increased lymphangiogenesis after peripheral nerve injury and repair. The findings suggest that Schwann cells may have an inhibitory effect on lymphatic vessel formation.
Article
Neurosciences
Bo Jia, Wei Huang, Yu Wang, Peng Zhang, Zhiwei Wang, Ming Zheng, Tianbing Wang
Summary: The study revealed that Nogo protein promotes Schwann cell apoptosis and inhibits Schwann cell dedifferentiation following peripheral nerve injury, ultimately hindering peripheral nerve regeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Environmental
Ying Ma, Hao Wang, Qiqi Wang, Xiaodong Cao, Huichang Gao
Summary: This study developed a multi-channel nerve guidance conduit (NGC) with dual electrical activity of piezoelectricity and conductivity to enhance peripheral nerve regeneration. In vitro and in vivo experiments demonstrated that the electroactive NGC promoted cell proliferation, differentiation, axonal regeneration, and functional recovery of peripheral nerves, indicating its great potential in repairing peripheral nerve injuries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yinying Shen, Zhangchun Cheng, Sailing Chen, Yunsong Zhang, Qi Chen, Sheng Yi
Summary: miR-29a-3p is up-regulated in injured sciatic nerves and inhibits Schwann cell proliferation and migration by negatively regulating PMP22. Injection of miR-29a-3p agomir hinders Schwann cell activities, delays axon elongation and myelination, and retards the functional recovery of injured nerves. This highlights the important role of miR-29a-3p/PMP22 in regulating Schwann cell phenotype following sciatic nerve injury and peripheral nerve regeneration.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Panjian Lu, Gang Wang, Xiaoheng Lu, Pingping Qiao, Yifei Jin, Jun Yu, Qi Chen, Hongkui Wang
Summary: Matrix metalloproteinase 9 (MMP9) is an important gene up-regulated during peripheral nerve regeneration, and it plays a significant role in Schwann cell migration and phenotype modulation. The direct application of MMP9 recombinant protein enhances the regeneration process in injured rats by promoting Schwann cell migration, blood vessel formation, axon elongation, and myelin wrapping. MMP9 regulates both the extracellular and intracellular metabolism of Schwann cells.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
David Gonzalez, Miguel L. Allende
Summary: Wallerian degeneration is a genetically conserved mechanism where peripheral nervous system axons have a higher capacity to regenerate. The use of zebrafish larvae and time-lapse microscopy allows for monitoring of the regenerative process of peripheral nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter, Steven A. Sloan
Summary: The response of Schwann cells to peripheral nerve injury involves the modulation of specific cellular pathways, including the downregulation of the AGE/RAGE pathway and secreted molecules Sparcl1 and Sema5a. These findings contribute to our understanding of neuroinflammation and provide valuable insights for improving CNS regeneration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Emily L. Errante, Anthony Diaz, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. Brooks, Yee-Shuan Lee, S. Shelby Burks, Allan D. Levi
Summary: Peripheral nerve injury (PNI) is common in trauma patients, and severe PNI can be challenging to treat. The use of cell therapies, particularly Schwann cells, has shown effectiveness in PNI treatment. Our laboratory has demonstrated the effectiveness of Schwann cells in the treatment of severe PNI when used with axon guidance channels, but optimal cellular placement techniques are crucial.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Orthopedics
Guidong Shi, Dingyu Hao, Lei Zhang, Jia Qin, Guangyuan Tian, Boyuan Ma, Xianhu Zhou
Summary: Through analysis of normal and activated Schwann cells, this study identified key genes and proteins involved in endocytosis and exosomes which may control the molecular mechanism of peripheral nerve repair. The study suggests that targeting endocytosis-associated pathways in Schwann cells could be a novel therapeutic approach for nerve tissue engineering and regeneration.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Neurosciences
Jesse Isaacman-Beck, Valerie Schneider, Clara Franzini-Armstrong, Michael Granato
Editorial Material
Multidisciplinary Sciences
Jesse Isaacman-Beck, Thomas R. Clandinin
Article
Biology
Yvette E. Fisher, Heien H. Yang, Jesse Isaacman-Beck, Marjorie Xie, Daryl M. Gohl, Thomas R. Clandinin
Article
Immunology
Yanjie Yi, Lamorris Loftin, Lingshu Wang, Sarah J. Ratcliffe, Jesse Isaacman-Beck, Ronald G. Collman
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2008)
Article
Virology
Jesse Isaacman-Beck, Emilia A. Hermann, Yanjie Yi, Sarah J. Ratcliffe, Joseph Mulenga, Susan Allen, Eric Hunter, Cynthia A. Derdeyn, Ronald G. Collman
JOURNAL OF VIROLOGY
(2009)
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Neurosciences
C. Akay, K. A. Lindl, Y. Wang, M. G. White, J. Isaacman-Beck, D. L. Kolson, K. L. Jordan-Sciutto
MOLECULAR AND CELLULAR NEUROSCIENCE
(2011)
Article
Multidisciplinary Sciences
Santanu Banerjee, Jesse Isaacman-Beck, Valerie A. Schneider, Michael Granato
Article
Neurosciences
Jesse Isaacman-Beck, Kristine C. Paik, Carl F. R. Wienecke, Helen H. Yang, Yvette E. Fisher, Irving E. Wang, Itzel G. Ishida, Gaby Maimon, Rachel Wilson, Thomas R. Clandinin
NATURE NEUROSCIENCE
(2020)