Tissue Culture Models of AKI: From Tubule Cells to Human Kidney Organoids

Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies

(2021) Marianne K. Vormann et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Three-dimensional spheroid culture induces apical-basal polarity and the original characteristics of immortalized human renal proximal tubule epithelial cells

(2021) Ken Mizuguchi et al.   EXPERIMENTAL CELL RESEARCH

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

(2021) Vidya Chandrasekaran et al.   Scientific Reports

The activation of antioxidant and apoptosis pathways involved in damage of human proximal tubule epithelial cells by PM2.5 exposure

(2020) Xiaoliu Huang et al.   Environmental Sciences Europe

Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip

(2020) Lei Yin et al.   Scientific Reports

Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury

(2020) Yizhen Sang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct

(2020) Huihui Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

(2020) Shin-Ichi Mae et al.   Cell Reports

A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity

(2020) Tom T.G. Nieskens et al.   DRUG METABOLISM AND DISPOSITION

Renal ischemia/reperfusion injury: An insight on in vitro and in vivo models

(2020) Niharika Shiva et al.   LIFE SCIENCES

Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

(2020) Juan Carlos Jado et al.   Antioxidants

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

(2020) Sara E. Howden et al.   Cell Stem Cell

Returning to kidney development to deliver synthetic kidneys

(2020) Melissa H. Little   DEVELOPMENTAL BIOLOGY

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

(2020) Kynan T. Lawlor et al.   NATURE MATERIALS

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

(2019) Alexander N. Combes et al.   Genome Medicine

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

(2019) Elena Garreta et al.   NATURE MATERIALS

Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1

(2019) Jessica M. Vanslambrouck et al.   KIDNEY INTERNATIONAL

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells

(2019) Santhosh V. Kumar et al.   DEVELOPMENT

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

(2019) Jian Hui Low et al.   Cell Stem Cell

Kidney organoids: accurate models or fortunate accidents

(2019) Melissa H. Little et al.   GENES & DEVELOPMENT

Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells

(2019) Markus Kleih et al.   Cell Death & Disease

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

(2019) Astgik Petrosyan et al.   Nature Communications

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2

(2019) Wei Li et al.   Biomed Research International

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

(2018) Thomas A. Forbes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury

(2018) Jinhua Tang et al.   CLINICAL SCIENCE

Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening

(2018) Michele Fedecostante et al.   DRUG METABOLISM AND DISPOSITION

Advances in predictive in vitro models of drug-induced nephrotoxicity

(2018) Joanne Y.-C. Soo et al.   Nature Reviews Nephrology

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

(2018) Cathelijne W. van den Berg et al.   Stem Cell Reports

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

(2018) Aneta Przepiorski et al.   Stem Cell Reports

Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip

(2018) Jelle Vriend et al.   AAPS Journal

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

(2018) Anna-Karin Sjögren et al.   ARCHIVES OF TOXICOLOGY

Emerging Kidney Models to Investigate Metabolism, Transport and Toxicity of Drugs and Xenobiotics

(2018) Piyush Bajaj et al.   DRUG METABOLISM AND DISPOSITION

CRISPR/Cas9 engineering of a KIM-1 reporter human proximal tubule cell line

(2018) Ruth Ann Veach et al.   PLoS One

Differentiation of human iPSCs into functional podocytes

(2018) Caroline Rauch et al.   PLoS One

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

(2018) Courtney Sakolish et al.   Scientific Reports

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

Biomarkers of drug-induced kidney toxicity

(2018) Benjamin R. Griffin et al.   THERAPEUTIC DRUG MONITORING

Molecular Mechanisms of Cardiotoxicity: A Review on Major Side-effect of Doxorubicin

(2017) M Mobaraki et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity

(2017) Rachel Murphy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis

(2017) Xiao-Ming Meng et al.   LABORATORY INVESTIGATION

NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation

(2017) Xiao-Ming Meng et al.   LABORATORY INVESTIGATION

Kidney Organoids: A Translational Journey

(2017) Ryuji Morizane et al.   TRENDS IN MOLECULAR MEDICINE

RPTEC/TERT1 cells form highly differentiated tubules when cultured in a 3D matrix

(2017) Philipp Secker   ALTEX-Alternatives to Animal Experimentation

Hyperoside alleviates adriamycin-induced podocyte injury via inhibiting mitochondrial fission

(2017) Zhuyun Chen et al.   Oncotarget

Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury

(2017) Yin Li et al.   Frontiers in Pharmacology

3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing

(2017) Shelby M. King et al.   Frontiers in Physiology

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex

(2017) Lisa Gianesello et al.   Scientific Reports

Heme Oxygenase-1 in Kidney Health and Disease

(2016) Jeremie M. Lever et al.   ANTIOXIDANTS & REDOX SIGNALING

Nebivolol Ameliorates Cisplatin-Induced Nephrotoxicity in Rats

(2016) Mohamed A. Morsy et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink

(2016) Weitao Jia et al.   BIOMATERIALS

The Usefulness of Determining Neutrophil Gelatinase-Associated Lipocalin Concentration Excreted in the Urine in the Evaluation of Cyclosporine A Nephrotoxicity in Children with Nephrotic Syndrome

(2016) Ewa Gacka et al.   DISEASE MARKERS

Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI

(2016) J. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors

(2016) Michael M. Kaminski et al.   NATURE CELL BIOLOGY

Generation of functional podocytes from human induced pluripotent stem cells

(2016) Osele Ciampi et al.   Stem Cell Research

The RPTEC/TERT1 Cell Line as an Improved Tool for In Vitro Nephrotoxicity Assessments

(2015) Bridget R. Simon-Friedt et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Protective effects of curcumin on acute gentamicin-induced nephrotoxicity in rats

(2015) Liyu He et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro

(2015) M. Adler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1

(2015) Lydia Aschauer et al.   TOXICOLOGY IN VITRO

Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study

(2015) Lydia Aschauer et al.   TOXICOLOGY IN VITRO

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro

(2015) Zhonghao Su et al.   Scientific Reports

Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods

(2015) Karthikeyan Kandasamy et al.   Scientific Reports

Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury

(2015) Seiji Kishi et al.   EBioMedicine

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

(2015) Yong-Min Choi et al.   PLoS One

The Rise and Fall of NGAL in Acute Kidney Injury

(2014) Johan Mårtensson et al.   BLOOD PURIFICATION

A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue

(2014) J. Jansen et al.   EXPERIMENTAL CELL RESEARCH

Urine interleukin-18 in prediction of acute kidney injury: a systemic review and meta-analysis

(2014) Xin Lin et al.   JOURNAL OF NEPHROLOGY

KIM-1 and NGAL as biomarkers of nephrotoxicity induced by gentamicin in rats

(2014) Qi-hui Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models

(2014) Ho Yee Tiong et al.   MOLECULAR PHARMACEUTICS

Identification of Nephrotoxic Compounds with Embryonic Stem-Cell-Derived Human Renal Proximal Tubular-Like Cells

(2014) Yao Li et al.   MOLECULAR PHARMACEUTICS

Efficient and Rapid Induction of Human iPSCs/ESCs into Nephrogenic Intermediate Mesoderm Using Small Molecule-Based Differentiation Methods

(2014) Toshikazu Araoka et al.   PLoS One

Differentiation of Human Pluripotent Stem Cells into Nephron Progenitor Cells in a Serum and Feeder Free System

(2014) Minyong Kang et al.   PLoS One

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

(2014) Abdullah Ozkok et al.   Biomed Research International

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

(2013) Atsuhiro Taguchi et al.   Cell Stem Cell

Human miRNome Profiling Identifies MicroRNAs Differentially Present in the Urine after Kidney Injury

(2013) K. Ramachandran et al.   CLINICAL CHEMISTRY

Heme oxygenase-1 and acute kidney injury

(2013) Karl A. Nath   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Interleukin 18 as a Marker of Chronic Nephropathy in Children after Anticancer Treatment

(2013) Małgorzata Zubowska et al.   DISEASE MARKERS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers

(2013) A. Q. Lam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human embryonic stem cells differentiate into functional renal proximal tubular–like cells

(2013) Karthikeyan Narayanan et al.   KIDNEY INTERNATIONAL

Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death

(2013) Z. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity

(2013) Teresa M. DesRochers et al.   PLoS One

In vitro evaluation of biomarkers for cisplatin-induced nephrotoxicity using HK-2 human kidney epithelial cells

(2013) So-Jung Sohn et al.   TOXICOLOGY LETTERS

The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model

(2013) Ender Hur et al.   International Journal of Endocrinology

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

(2013) Shin-Ichi Mae et al.   Nature Communications

An in vitro method for the prediction of renal proximal tubular toxicity in humans

(2013) Yao Li et al.   Toxicology Research

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

(2013) Nataliya I. Skrypnyk et al.   Jove-Journal of Visualized Experiments

A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways

(2012) Sankhadeep Pal et al.   BIOCHIMIE

Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines

(2012) Anna I. Astashkina et al.   BIOMATERIALS

Design of Clinical Trials in Acute Kidney Injury: Report from an NIDDK Workshop on Trial Methodology

(2012) P. M. Palevsky et al.   Clinical Journal of the American Society of Nephrology

Human AKI and Heme Oxygenase-1

(2012) K. A. Nath   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In Vivo Maturation of Functional Renal Organoids Formed from Embryonic Cell Suspensions

(2012) C. Xinaris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasma and Urinary Heme Oxygenase-1 in AKI

(2012) R. A. Zager et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule

(2012) Sarah E. Jenkinson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Drug transport by Organic Anion Transporters (OATs)

(2012) Gerhard Burckhardt   PHARMACOLOGY & THERAPEUTICS

The Directed Differentiation of Human iPS Cells into Kidney Podocytes

(2012) Bi Song et al.   PLoS One

The performance of primary human renal cells in hollow fiber bioreactors for bioartificial kidneys

(2011) Zay Yar Oo et al.   BIOMATERIALS

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity

(2010) Takanori Nakamura et al.   BIOCHEMICAL PHARMACOLOGY

New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view

(2010) Jose M. Lopez-Novoa et al.   KIDNEY INTERNATIONAL

Adriamycin nephropathy: A model of focal segmental glomerulosclerosis

(2010) VINCENT WS LEE et al.   NEPHROLOGY

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

(2009) Martijn J. Wilmer et al.   CELL AND TISSUE RESEARCH

Mesenchymal Stem Cells Protective Effect in Adriamycin Model of Nephropathy

(2009) Alberto Magnasco et al.   CELL TRANSPLANTATION

Comparative Analysis of Novel Noninvasive Renal Biomarkers and Metabonomic Changes in a Rat Model of Gentamicin Nephrotoxicity

(2009) Max Sieber et al.   TOXICOLOGICAL SCIENCES

Heme Oxygenase-1 Deficiency Promotes Epithelial-Mesenchymal Transition and Renal Fibrosis

(2008) J.-H. Kie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bisphosphonate nephrotoxicity

(2008) Mark A. Perazella et al.   KIDNEY INTERNATIONAL

Evaluation of Putative Biomarkers of Nephrotoxicity after Exposure to Ochratoxin A In Vivo and In Vitro

(2008) Eva Rached et al.   TOXICOLOGICAL SCIENCES