A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity

(2018) Tom T. G. Nieskens et al.   DRUG METABOLISM AND DISPOSITION

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

(2018) Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

(2017) Pekka Kohonen et al.   Nature Communications

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

(2016) Tom T. G. Nieskens et al.   AAPS Journal

Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line

(2016) Pedro Caetano-Pinto et al.   MOLECULAR PHARMACEUTICS

Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane

(2015) Carolien M.S. Schophuizen et al.   Acta Biomaterialia

High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures

(2015) Ran Su et al.   ARCHIVES OF TOXICOLOGY

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro

(2015) M. Adler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods

(2015) Karthikeyan Kandasamy et al.   Scientific Reports

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue

(2014) J. Jansen et al.   EXPERIMENTAL CELL RESEARCH

Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research

(2014) Pascale Fisel et al.   Expert Opinion on Drug Metabolism & Toxicology

How can we discover safer drugs?

(2014) Jorrit J Hornberg et al.   Future Medicinal Chemistry

Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models

(2014) Ho Yee Tiong et al.   MOLECULAR PHARMACEUTICS

Identification of Nephrotoxic Compounds with Embryonic Stem-Cell-Derived Human Renal Proximal Tubular-Like Cells

(2014) Yao Li et al.   MOLECULAR PHARMACEUTICS

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Primary porcine proximal tubular cells as an alternative to human primary renal cells in vitro: an initial characterization

(2013) Alexandra H Heussner et al.   BMC CELL BIOLOGY

Engineered renal tissue as a potential platform for pharmacokinetic and nephrotoxicity testing

(2013) Jamie Davies   DRUG DISCOVERY TODAY

Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies

(2013) Jorrit J. Hornberg et al.   DRUG DISCOVERY TODAY

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

(2013) Jorrit J. Hornberg et al.   DRUG DISCOVERY TODAY

Human embryonic stem cells differentiate into functional renal proximal tubular–like cells

(2013) Karthikeyan Narayanan et al.   KIDNEY INTERNATIONAL

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

(2013) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An in vitro method for the prediction of renal proximal tubular toxicity in humans

(2013) Yao Li et al.   Toxicology Research

The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule

(2012) Sarah E. Jenkinson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Why Do We Use 600 mg of Rifampicin in Tuberculosis Treatment?

(2011) J. van Ingen et al.   CLINICAL INFECTIOUS DISEASES

Tenofovir renal proximal tubular toxicity is regulated By OAT1 and MRP4 transporters

(2011) James J Kohler et al.   LABORATORY INVESTIGATION

Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines

(2011) Zhiwu Lin et al.   TOXICOLOGICAL SCIENCES

Molecular and functional characterization of choline transporter in rat renal tubule epithelial NRK-52E cells

(2009) Minako Yabuki et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

(2009) Martijn J. Wilmer et al.   CELL AND TISSUE RESEARCH

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

(2008) Colin D.A. Brown et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY