NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

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RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms

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Carnosic acid attenuates unilateral ureteral obstruction-induced kidney fibrosis via inhibition of Akt-mediated Nox4 expression

(2016) Kyong-Jin Jung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity

(2016) Qian Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea

(2016) T. Kaur et al.   JOURNAL OF NEUROSCIENCE

Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties

(2016) R. Galgamuwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

MicroRNAs and drug-induced kidney injury

(2016) Mira Pavkovic et al.   PHARMACOLOGY & THERAPEUTICS

CXCL16 regulates cisplatin-induced acute kidney injury

(2016) Hua Liang et al.   Oncotarget

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury

(2016) Stellor Nlandu-Khodo et al.   Scientific Reports

Nox and renal disease

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Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

(2015) Jay C. Jha et al.   DIABETOLOGIA

Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism

(2015) Yimin Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

(2015) Y. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Necroinflammation in Kidney Disease

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Acute kidney injury in China: a cross-sectional survey

(2015) Li Yang et al.   LANCET

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis

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Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods

(2015) Karthikeyan Kandasamy et al.   Scientific Reports

NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2 

(2014) J. L. Gregg et al.   CANCER RESEARCH

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Incidence, Outcomes, and Comparisons across Definitions of AKI in Hospitalized Individuals

(2013) X. Zeng et al.   Clinical Journal of the American Society of Nephrology

Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?

(2013) Yves Gorin et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH Oxidases, Reactive Oxygen Species, and the Kidney: Friend and Foe

(2013) M. Sedeek et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells

(2012) Giulia Benedetti et al.   BIOCHEMICAL PHARMACOLOGY

Role of Nox4 in murine models of kidney disease

(2012) Andrea Babelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signaling through the interleukin-18 receptor α attenuates inflammation in cisplatin-induced acute kidney injury

(2012) Yuji Nozaki et al.   KIDNEY INTERNATIONAL

NAD(P)H oxidase and renal epithelial ion transport

(2011) Carlos Schreck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity

(2011) Penélope D. Sánchez-González et al.   CRITICAL REVIEWS IN TOXICOLOGY

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro

(2011) Xiao-Ming Meng et al.   JOURNAL OF PATHOLOGY

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

(2011) Xiao-Ming Meng et al.   KIDNEY INTERNATIONAL