Structural basis for therapeutic inhibition of complement C5

Cryogenic Electron Microscopy and Single-Particle Analysis

(2015) Dominika Elmlund et al.   Annual Review of Biochemistry

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

(2015) Evelien T. M. Berends et al.   BMC BIOLOGY

Applying complement therapeutics to rare diseases

(2015) Edimara S. Reis et al.   CLINICAL IMMUNOLOGY

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

(2015) Sofia Mortensen et al.   JOURNAL OF IMMUNOLOGY

Genetic Variants in C5 and Poor Response to Eculizumab

(2014) Jun-ichi Nishimura et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems

(2013) Paul D. Adams et al.   Annual Review of Biophysics

Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury

(2013) Pietro Roversi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Novel roles for complement receptors in T cell regulation and beyond

(2013) Claudia Kemper et al.   MOLECULAR IMMUNOLOGY

PRIME: Probabilistic Initial 3D Model Generation for Single-Particle Cryo-Electron Microscopy

(2013) Hans Elmlund et al.   STRUCTURE

Improved chemical shift prediction by Rosetta conformational sampling

(2012) Ye Tian et al.   JOURNAL OF BIOMOLECULAR NMR

SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles

(2012) Dominika Elmlund et al.   JOURNAL OF STRUCTURAL BIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Ornithodoros moubata Complement Inhibitor Is an Equally Effective C5 Inhibitor in Pigs and Humans

(2011) A. Barratt-Due et al.   JOURNAL OF IMMUNOLOGY

UCSF Chimera, MODELLER, and IMP: An integrated modeling system

(2011) Zheng Yang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

Full-length transcriptome assembly from RNA-Seq data without a reference genome

(2011) Manfred G Grabherr et al.   NATURE BIOTECHNOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

(2010) Nick S. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution structure of a unique C5a semi-synthetic antagonist: Implications in receptor binding

(2010) Xiaolu Zhang et al.   PROTEIN SCIENCE

The internal thioester and the covalent binding properties of the complement proteins C3 and C4

(2010) S. K. Alex Law et al.   PROTEIN SCIENCE

Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets

(2010) R. Manjunatha Kini et al.   TOXICON

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

(2009) Bert J C Janssen et al.   EMBO JOURNAL

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

(2009) Suzan H M Rooijakkers et al.   NATURE IMMUNOLOGY

Function, mechanism and evolution of the moubatin-clade of soft tick lipocalins

(2008) Ben J. Mans et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structure of and influence of a tick complement inhibitor on human complement component 5

(2008) Folmer Fredslund et al.   NATURE IMMUNOLOGY

Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo

(2007) Natalie J. Hepburn et al.   MOLECULAR IMMUNOLOGY