Nanoparticle and virus-like particle vaccine approaches against SARS-CoV-2

Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates

(2021) Yin-Feng Kang et al.   ACS Nano

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

(2021) Philip J.M. Brouwer et al.   CELL

A stable platform for the production of virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein

(2021) Roy Sylvie et al.   VIRUS RESEARCH

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

(2021) Tiong Kit Tan et al.   Nature Communications

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

(2021) Abigail E. Powell et al.   ACS Central Science

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

(2021) Yongping Yang et al.   Vaccines

The Next Generation of Influenza Vaccines: Towards a Universal Solution

(2021) Christopher L.D. McMillan et al.   Vaccines

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers

(2021) Alexander A. Cohen et al.   PLoS One

The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic

(2021) Priyanka Shah et al.   Frontiers in Immunology

Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages

(2021) Umesh Kalathiya et al.   Biomolecules

Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys

(2021) Heng Li et al.   BIOCONJUGATE CHEMISTRY

National Study of Youth Opinions on Vaccination for COVID-19 in the U.S.

(2021) Eric J. Brandt et al.   JOURNAL OF ADOLESCENT HEALTH

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

(2021) Prabhu S. Arunachalam et al.   NATURE

Quadrivalent influenza nanoparticle vaccines induce broad protection

(2021) Seyhan Boyoglu-Barnum et al.   NATURE

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization

(2021) Alexandru A. Hennrich et al.   PLoS Pathogens

Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

(2021) Linling He et al.   Science Advances

Protein-based antigen presentation platforms for nanoparticle vaccines

(2021) Brian Nguyen et al.   npj Vaccines

AP205 VLPs Based on Dimerized Capsid Proteins Accommodate RBM Domain of SARS-CoV-2 and Serve as an Attractive Vaccine Candidate

(2021) Xuelan Liu et al.   Vaccines

A scalable and highly immunogenic virus‐like particle‐based vaccine against SARS‐CoV‐2

(2021) Mona O. Mohsen et al.   ALLERGY

Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice

(2021) Ralf Salzer et al.   FEBS LETTERS

A self-assembling nanoparticle: Implications for the development of thermostable vaccine candidates

(2021) Ze-Hui Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

(2021) Shipo Wu et al.   LANCET INFECTIOUS DISEASES

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

(2021) Hannah A. D. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

(2021) Neil C. Dalvie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain

(2021) Daniela I. Staquicini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel competition ELISA for the rapid quantification of SARS‐CoV ‐2 neutralizing antibodies in convalescent plasma

(2021) Elise Wouters et al.   TRANSFUSION

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

(2021) Qibin Geng et al.   PLoS Pathogens

Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial

(2021) Hans de Graaf et al.   Frontiers in Immunology

Self-Assembling Nanovaccine Enhances Protective Efficacy Against CSFV in Pigs

(2021) Ze-Hui Liu et al.   Frontiers in Immunology

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination

(2021) Han W. Kim et al.   JAMA Cardiology

Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate Vaccines

(2021) Puna Maya Maharjan et al.   Vaccines

Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains

(2021) Ki-Back Chu et al.   Vaccines

Potent neutralization of SARS‐CoV ‐2 including variants of concern by vaccines presenting the receptor‐binding domain multivalently from nanoscaffolds

(2021) Peter J. Halfmann et al.   Bioengineering & Translational Medicine

Estimating the early impact of the US COVID-19 vaccination programme on COVID-19 cases, emergency department visits, hospital admissions, and deaths among adults aged 65 years and older: an ecological analysis of national surveillance data

(2021) Lucy A McNamara et al.   LANCET

RNA-dependent assembly of chimeric antigen nanoparticles as an efficient H5N1 pre-pandemic vaccine platform

(2021) Jongkwan Lim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants

(2021) Linda van Oosten et al.   mBio

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

(2021) Kathryn McGuckin Wuertz et al.   npj Vaccines

BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype

(2021) Gisella Guerrera et al.   Science Immunology

Safety and immunogenicity of ChAdOx1 MERS vaccine candidate in healthy Middle Eastern adults (MERS002): an open-label, non-randomised, dose-escalation, phase 1b trial

(2021) Mohammad Bosaeed et al.   Lancet Microbe

Coronavirus Infections—More Than Just the Common Cold

(2020) Catharine I. Paules et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

(2020) Feng-Cai Zhu et al.   LANCET

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

(2020) Jingyou Yu et al.   SCIENCE

A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain

(2020) Kurt A. Swanson et al.   Science Immunology

Advanced Analysis of Biosensor Data for SARS-CoV-2 RBD and ACE2 Interactions

(2020) Patrik Forssén et al.   ANALYTICAL CHEMISTRY

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice

(2020) James Brett Case et al.   Cell Host & Microbe

Shaping humoral immunity to vaccines through antigen-displaying nanoparticles

(2020) Darrell J Irvine et al.   CURRENT OPINION IN IMMUNOLOGY

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

(2020) Emilie Seydoux et al.   IMMUNITY

Global Seasonality of Human Seasonal Coronaviruses: A Clue for Postpandemic Circulating Season of Severe Acute Respiratory Syndrome Coronavirus 2?

(2020) You Li et al.   JOURNAL OF INFECTIOUS DISEASES

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Feng-Cai Zhu et al.   LANCET

Chaperna: linking the ancient RNA and protein worlds

(2020) Ahyun Son et al.   RNA Biology

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

(2020) Philip J. M. Brouwer et al.   SCIENCE

Interaction Between Virus-Like Particles (VLPs) and Pattern Recognition Receptors (PRRs) From Dendritic Cells (DCs): Toward Better Engineering of VLPs

(2020) Jesús Zepeda-Cervantes et al.   Frontiers in Immunology

Overcoming Symmetry Mismatch in Vaccine Nanoassembly via Spontaneous Amidation

(2020) Mark Howarth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

(2020) Ahmed O. Hassan et al.   CELL

The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies

(2020) Soheila Molaei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

(2020) Zunlong Ke et al.   NATURE

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

(2020) Liqiang Feng et al.   Nature Communications

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

(2020) Shipo Wu et al.   Nature Communications

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

(2020) Baoshan Zhang et al.   Scientific Reports

Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2

(2020) Drishya Kurup et al.   npj Vaccines

Seasonality of Respiratory Viral Infections: Will COVID-19 Follow Suit?

(2020) Amani Audi et al.   Frontiers in Public Health

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses

(2020) Xiancai Ma et al.   IMMUNITY

Correlates of protection against SARS-CoV-2 in rhesus macaques

(2020) Katherine McMahan et al.   NATURE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

(2020) Yfat Yahalom-Ronen et al.   Nature Communications

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

(2020) Weina Sun et al.   Vaccines

Immunological basis for enhanced immunity of nanoparticle vaccines

(2019) Hannah G Kelly et al.   Expert Review of Vaccines

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Role of Multivalency and Antigenic Threshold in Generating Protective Antibody Responses

(2019) Mark K. Slifka et al.   Frontiers in Immunology

Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design

(2019) Jeong Yoon Lee et al.   JOURNAL OF MICROBIOLOGY

Middle East Respiratory Syndrome Coronavirus-Encoded Accessory Proteins Impair MDA5-and TBK1-Mediated Activation of NF-��B

(2019) Jeong Yoon Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

(2019) Philip J. M. Brouwer et al.   Nature Communications

Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels

(2019) Naif Khalaf Alharbi et al.   Scientific Reports

Engineering a Rugged Nanoscaffold to Enhance Plug-and-Display Vaccination

(2018) Theodora Ulli Jordanka Bruun et al.   ACS Nano

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Intranasal Nanovaccine Confers Homo- and Hetero-Subtypic Influenza Protection

(2018) Mi Qi et al.   Small

Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles

(2018) Young-Seok Kim et al.   Frontiers in Immunology

Prospects for a MERS-CoV spike vaccine

(2018) Yusen Zhou et al.   Expert Review of Vaccines

MERS coronavirus outbreak: Implications for emerging viral infections

(2018) Awad Al-Omari et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Combination of RTS,S and Pfs25-IMX313 Induces a Functional Antibody Response Against Malaria Infection and Transmission in Mice

(2018) Florian Brod et al.   Frontiers in Immunology

Platform technologies for modern vaccine manufacturing

(2017) Hayley K. Charlton Hume et al.   VACCINE

Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer’s and cat allergy

(2017) Andris Zeltins et al.   npj Vaccines

Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines

(2017) Darren B. Leneghan et al.   Scientific Reports

The life cycle of a T cell after vaccination - where does immune ageing strike?

(2016) C. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Strategies for designing synthetic immune agonists

(2016) Tom Y.-H. Wu   IMMUNOLOGY

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults

(2016) Alice Minhinnick et al.   VACCINE

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

(2016) Linling He et al.   Nature Communications

A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice

(2016) Khamis Tomusange et al.   Scientific Reports

Engineering virus-like particles as vaccine platforms

(2016) Kathryn M Frietze et al.   Current Opinion in Virology

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

(2016) Yuanyuan Li et al.   Scientific Reports

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

(2016) Karl D. Brune et al.   Scientific Reports

Different applications of virus-like particles in biology and medicine: Vaccination and delivery systems

(2015) Zeinab Shirbaghaee et al.   BIOPOLYMERS

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

Assessing sequence plasticity of a virus-like nanoparticle by evolution toward a versatile scaffold for vaccines and drug delivery

(2015) Yuan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

(2014) John P. Ray et al.   IMMUNITY

Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization

(2014) Catherine A. Fromen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adverse events following immunization in Ontario's female school-based HPV program

(2014) Tara Harris et al.   VACCINE

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates

(2012) Alexandra J. Spencer et al.   PLoS One

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

(2012) Shibo Jiang et al.   Emerging Microbes & Infections

Surface Functionalization of Virus-Like Particles by Direct Conjugation Using Azide−Alkyne Click Chemistry

(2011) Kedar G. Patel et al.   BIOCONJUGATE CHEMISTRY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria

(2008) S. A. Ogun et al.   INFECTION AND IMMUNITY