The life cycle of a T cell after vaccination - where does immune ageing strike?

Characterization of age-associated exhausted CD8+T cells defined by increased expression of Tim-3 and PD-1

(2016) Kyoo-A Lee et al.   AGING CELL

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+T cells in aged mice

(2016) Kylie M. Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination

(2016) Qian Qi et al.   Science Translational Medicine

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

(2016) Fengqin Fang et al.   Cell Reports

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

(2016) Lianjun Zhang et al.   Cell Reports

Reduced naïve CD8+T-cell priming efficacy in elderly adults

(2015) Olivia Briceño et al.   AGING CELL

DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia

(2015) A. Bignon et al.   BLOOD

Clinical Effectiveness of Split-Virion Versus Subunit Trivalent Influenza Vaccines in Older Adults

(2015) H. K. Talbot et al.   CLINICAL INFECTIOUS DISEASES

Age-associated telomere attrition of lymphocytesin vivois co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

(2015) Yun Lin et al.   CLINICAL SCIENCE

Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+T-cell proliferation by distinct pathways

(2015) Sian M. Henson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation

(2015) Guangjin Li et al.   JOURNAL OF IMMUNOLOGY

Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans

(2015) Axel Ronald Schulz et al.   JOURNAL OF IMMUNOLOGY

Pathophysiology of T follicular helper cells in humans and mice

(2015) Hideki Ueno et al.   NATURE IMMUNOLOGY

Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

(2015) Himal Lal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developing vaccines for an aging population

(2015) Steven Black et al.   Science Translational Medicine

High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

(2015) Jörg J. Goronzy et al.   Genome Medicine

Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

(2015) Neha R Deshpande et al.   eLife

Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?

(2014) Qian Qi et al.   EXPERIMENTAL GERONTOLOGY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

(2014) Carlos A. DiazGranados et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systems vaccinology: Probing humanity's diverse immune systems with vaccines

(2014) B. Pulendran   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

(2014) T. Cukalac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained Interactions between T Cell Receptors and Antigens Promote the Differentiation of CD4+ Memory T Cells

(2013) Chulwoo Kim et al.   IMMUNITY

The Quadrivalent Approach to Influenza Vaccination

(2013) R. Dolin   JOURNAL OF INFECTIOUS DISEASES

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

(2013) Douglas V. Dolfi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gamma Interferon Regulates Contraction of the Influenza Virus-Specific CD8 T Cell Response and Limits the Size of the Memory Population

(2013) Nayana Prabhu et al.   JOURNAL OF VIROLOGY

AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial

(2013) Janet E McElhaney et al.   LANCET INFECTIOUS DISEASES

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Cochrane re-arranged: Support for policies to vaccinate elderly people against influenza

(2013) Walter E.P. Beyer et al.   VACCINE

The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly

(2013) P.G. Van Buynder et al.   VACCINE

Herpes Zoster Vaccine Effectiveness against Incident Herpes Zoster and Post-herpetic Neuralgia in an Older US Population: A Cohort Study

(2013) Sinéad M. Langan et al.   PLOS MEDICINE

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Efficacy, Safety, and Tolerability of Herpes Zoster Vaccine in Persons Aged 50-59 Years

(2012) K. E. Schmader et al.   CLINICAL INFECTIOUS DISEASES

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire

(2012) W. W. Kwok et al.   JOURNAL OF IMMUNOLOGY

Rapid and Massive Virus-Specific Plasmablast Responses during Acute Dengue Virus Infection in Humans

(2012) J. Wrammert et al.   JOURNAL OF VIROLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age

(2012) P. L. F. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

(2012) M. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related changes in CD8 T cell homeostasis and immunity to infection

(2012) Janko Nikolich-Žugich et al.   SEMINARS IN IMMUNOLOGY

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

(2011) Heather D. Marshall et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Herpes Zoster Vaccine in Older Adults and the Risk of Subsequent Herpes Zoster Disease

(2011) Hung Fu Tseng   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

(2011) Sanae Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Longitudinal versus Cross-sectional Evaluations of Leukocyte Telomere Length Dynamics: Age-Dependent Telomere Shortening is the Rule

(2011) W. Chen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

CD4 T Cell Immunity Is Critical for the Control of Simian Varicella Virus Infection in a Nonhuman Primate Model of VZV Infection

(2011) Kristen Haberthur et al.   PLoS Pathogens

Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages

(2010) D. L. Lamar et al.   BLOOD

Immune mechanisms of protection: can adjuvants rise to the challenge?

(2010) Amy S McKee et al.   BMC BIOLOGY

Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors

(2010) G. N. Malavige et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool

(2010) Chulwoo Kim et al.   IMMUNOLOGY

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

(2010) Nicole L. La Gruta et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Randomized, Double‐Blind Controlled Phase 3 Trial Comparing the Immunogenicity of High‐Dose and Standard‐Dose Influenza Vaccine in Adults 65 Years of Age and Older

(2009) Ann R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

(2009) E. Teixeiro et al.   SCIENCE

Recruitment of Antigen-Specific CD8+ T Cells in Response to Infection Is Markedly Efficient

(2009) J. W. J. van Heijst et al.   SCIENCE

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

(2009) Janet E. McElhaney et al.   VACCINE

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory

(2008) Matthew A. Williams et al.   IMMUNITY

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

(2008) Joshua J. Obar et al.   IMMUNITY

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

(2008) Surojit Sarkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE