Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate Vaccines

Development of Plant-Produced Recombinant ACE2-Fc Fusion Protein as a Potential Therapeutic Agent Against SARS-CoV-2

(2021) Konlavat Siriwattananon et al.   Frontiers in Plant Science

Phase III: Randomized observer-blind trial to evaluate lot-to-lot consistency of a new plant-derived quadrivalent virus like particle influenza vaccine in adults 18–49 years of age

(2021) Brian J. Ward et al.   VACCINE

COVID-19 Crisis: How Can Plant Biotechnology Help?

(2021) Md. Jahidul Islam Shohag et al.   Plants-Basel

Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies

(2021) Lianlian Bian et al.   Expert Review of Vaccines

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

(2021) Brian J. Ward et al.   NATURE MEDICINE

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

(2021) Nuno R. Faria et al.   SCIENCE

SARS-CoV-2 Antigens Expressed in Plants Detect Antibody Responses in COVID-19 Patients

(2021) Mohau S. Makatsa et al.   Frontiers in Plant Science

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

(2021) Yingzhu Li et al.   ACS Central Science

Plant-Expressed Receptor Binding Domain of the SARS-CoV-2 Spike Protein Elicits Humoral Immunity in Mice

(2021) Puna Maya Maharjan et al.   Vaccines

Molecular farming – The slope of enlightenment

(2020) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Plant-made HIV vaccines and potential candidates

(2020) Jocelyne Tremouillaux-Guiller et al.   CURRENT OPINION IN BIOTECHNOLOGY

Host protein glycosylation in nucleic acid vaccines as a potential hurdle in vaccine design for nonviral pathogens

(2020) Ahmet Ozdilek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

SARS‐CoV‐2 immunogenicity at the crossroads

(2020) Fariba Karamloo et al.   ALLERGY

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Will plant-made biopharmaceuticals play a role in the fight against COVID-19?

(2020) Sergio Rosales-Mendoza   EXPERT OPINION ON BIOLOGICAL THERAPY

Evaluation of Nucleocapsid and Spike Protein-Based Enzyme-Linked Immunosorbent Assays for Detecting Antibodies against SARS-CoV-2

(2020) Wanbing Liu et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Site-specific glycan analysis of the SARS-CoV-2 spike

(2020) Yasunori Watanabe et al.   SCIENCE

Potential Applications of Plant Biotechnology against SARS-CoV-2

(2020) Teresa Capell et al.   TRENDS IN PLANT SCIENCE

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

(2020) Sisi Kang et al.   Acta Pharmaceutica Sinica B

What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?

(2020) Sergio Rosales-Mendoza et al.   Vaccines

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

(2020) Qianqian Li et al.   CELL

SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines

(2020) Ian G Barr et al.   Eurosurveillance

The Nucleocapsid Protein of SARS–CoV-2: a Target for Vaccine Development

(2020) Noton K. Dutta et al.   JOURNAL OF VIROLOGY

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

(2020) Philip J. M. Brouwer et al.   SCIENCE

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

(2020) Andrew Rambaut et al.   Nature Microbiology

From Farm to Finger Prick—A Perspective on How Plants Can Help in the Fight Against COVID-19

(2020) Karen A. McDonald et al.   Frontiers in Bioengineering and Biotechnology

Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production

(2020) Balamurugan Shanmugaraj et al.   Plants-Basel

Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials

(2020) Brian J Ward et al.   LANCET

Plant‐made dengue virus‐like particles produced by co‐expression of structural and non‐structural proteins induce a humoral immune response in mice

(2020) Daniel Ponndorf et al.   PLANT BIOTECHNOLOGY JOURNAL

Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamiana

(2020) Kaewta Rattanapisit et al.   Scientific Reports

The Emergency Response Capacity of Plant-Based Biopharmaceutical Manufacturing-What It Is and What It Could Be

(2020) Daniel Tusé et al.   Frontiers in Plant Science

The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies

(2020) Anastassios C. Papageorgiou et al.   Cells

Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein

(2020) René Wintjens et al.   npj Vaccines

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization

(2020) Eric Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Plant-Based Vaccines: The Way Ahead?

(2020) Zacharie LeBlanc et al.   Viruses-Basel

Plant-based vaccines and antibodies to combat COVID-19: current status and prospects

(2020) Kuldeep Dhama et al.   Human Vaccines & Immunotherapeutics

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

(2020) Mei-Yue Wang et al.   Frontiers in Cellular and Infection Microbiology

Plant Molecular Farming as a Strategy Against COVID-19 – The Italian Perspective

(2020) Chiara Lico et al.   Frontiers in Plant Science

Monoclonal Antibodies B38 and H4 Produced in Nicotiana benthamiana Neutralize SARS-CoV-2 in vitro

(2020) Balamurugan Shanmugaraj et al.   Frontiers in Plant Science

COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies

(2020) Kajal Rawat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dynamic anti-spike protein antibody profiles in COVID-19 patients

(2020) Yujie Bao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Current state-of-the-art in plant-based antibody production systems

(2019) Marcello Donini et al.   BIOTECHNOLOGY LETTERS

Safety of AS03-adjuvanted influenza vaccines: A review of the evidence

(2019) Catherine Cohet et al.   VACCINE

Edible Vaccines: Promises and Challenges

(2019) Vrinda M Kurup et al.   MOLECULAR BIOTECHNOLOGY

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

(2019) Sabue Mulangu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of Systems for the Production of Plant-Derived Biopharmaceuticals

(2019) Ki-Beom Moon et al.   Plants-Basel

Plant-Produced Subunit Vaccine Candidates against Yellow Fever Induce Virus Neutralizing Antibodies and Confer Protection against Viral Challenge in Animal Models

(2018) Stephen Tottey et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Recommendations of the Advisory Committee on Immunization Practices for Use of a Hepatitis B Vaccine with a Novel Adjuvant

(2018) Sarah Schillie et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial

(2018) Stéphane Pillet et al.   npj Vaccines

Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model

(2018) Mey-Fann Lee et al.   PLoS One

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

(2018) Jessica A. Chichester et al.   VACCINE

Production of tetravalent dengue virus envelope protein domain III based antigens in lettuce chloroplasts and immunologic analysis for future oral vaccine development

(2018) André van Eerde et al.   PLANT BIOTECHNOLOGY JOURNAL

Molecular pharming’s foot in the FDA’s door: Protalix’s trailblazing story

(2015) Tsafrir S. Mor   BIOTECHNOLOGY LETTERS

Immunotherapy of HPV-associated cancer: DNA/plant-derived vaccines and new orthotopic mouse models

(2015) Aldo Venuti et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Plants as Factories for Human Pharmaceuticals: Applications and Challenges

(2015) Jian Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plant-made oral vaccines against human infectious diseases-Are we there yet?

(2015) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-produced candidate countermeasures against emerging and reemerging infections and bioterror agents

(2015) Stephen J. Streatfield et al.   PLANT BIOTECHNOLOGY JOURNAL

Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants

(2015) Koji Kashima et al.   PLANT CELL REPORTS

Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets

(2015) S. Pillet et al.   VACCINE

Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana

(2015) Francisco F. P. G. Pêra et al.   Virology Journal

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Fighting Ebola with ZMapp: spotlight on plant-made antibody

(2014) YunFang Zhang et al.   Science China-Life Sciences

Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses

(2014) Ingrid Lindh et al.   VACCINE

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Immunogenic properties of a lettuce-derived C4(V3)6 multiepitopic HIV protein

(2013) Dania O. Govea-Alonso et al.   PLANTA

A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized Mice

(2013) R. Mark Jones et al.   PLoS One

Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: A Phase 1 dose-escalation study in healthy adults

(2013) James F. Cummings et al.   VACCINE

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

(2012) Nathalie Garçon et al.   Expert Review of Vaccines

First plant-made biologic approved

(2012) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

(2012) Jessica Chichester et al.   Viruses-Basel

Plant-derived virus-like particles as vaccines

(2012) Qiang Chen et al.   Human Vaccines & Immunotherapeutics

A plant-based system for rapid production of influenza vaccine antigens

(2011) Yoko Shoji et al.   Influenza and Other Respiratory Viruses

Extraction, purification and characterization of the plant-produced HPV16 subunit vaccine candidate E7 GGG

(2011) J.F. Buyel et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

(2011) Waranyoo Phoolcharoen et al.   PLANT BIOTECHNOLOGY JOURNAL

Virus-like particles: potential veterinary vaccine immunogens

(2011) Fuxiao Liu et al.   RESEARCH IN VETERINARY SCIENCE

Plant glycans: friend or foe in vaccine development?

(2010) Dirk Bosch et al.   Expert Review of Vaccines

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Prevention of bubonic and pneumonic plague using plant-derived vaccines

(2009) M. Lucrecia Alvarez et al.   BIOTECHNOLOGY ADVANCES

A Rice-Based Oral Cholera Vaccine Induces Macaque-Specific Systemic Neutralizing Antibodies but Does Not Influence Pre-Existing Intestinal Immunity

(2009) T. Nochi et al.   JOURNAL OF IMMUNOLOGY

A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague

(2009) Jessica A. Chichester et al.   VACCINE

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY

Plant-produced vaccines: promise and reality

(2008) Edward P. Rybicki   DRUG DISCOVERY TODAY

Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in Chloroplasts

(2008) P. A. Arlen et al.   INFECTION AND IMMUNITY

A plant-produced influenza subunit vaccine protects ferrets against virus challenge

(2008) Vadim Mett et al.   Influenza and Other Respiratory Viruses

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL