Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma

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(2021) Sharanya Maanasi Kalasekar et al.   HEPATOLOGY

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

(2021) Zaoqu Liu et al.   Journal of Translational Medicine

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(2021) Josep M. Llovet et al.   Nature Reviews Disease Primers

Calreticulin—Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients

(2021) Michal Kielbik et al.   Cells

An overview of anticancer platinum N-heterocyclic carbene complexes

(2021) Sai Zhao et al.   COORDINATION CHEMISTRY REVIEWS

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(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

(2020) Hongzhang Deng et al.   NANO LETTERS

A novel platinum-based chemotherapeutic inducing immunogenic cell death

(2020) Oliver Kepp et al.   OncoImmunology

A Platinum(IV) Prodrug – Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain

(2020) Colin M. Fadzen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

(2020) Zhiqin Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death

(2020) Zahra Asadzadeh et al.   Cancers

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

(2020) Joanna Kopecka et al.   Cells

PlatinER: a Highly Potent Anticancer Platinum(II) Complex that induces Endoplasmic Reticulum Stress‐driven Immunogenic Cell Death

(2020) Max Jing Rui Tham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

(2020) Jing‐Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent in Vitro and in Vivo Anticancer Activity Against HCC

(2020) Mianli Bian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oncolytic HSV therapy modulates vesicular trafficking inducing cisplatin sensitivity and anti-tumor immunity

(2020) Balveen Kaur et al.   CLINICAL CANCER RESEARCH

Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy

(2020) Hanzhang Zhu et al.   CELLULAR ONCOLOGY

An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer

(2020) Lili Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New copper complexes inducing bimodal death through apoptosis and autophagy in A549 cancer cells

(2020) Noor Shad Gul et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer

(2020) Sajal Sen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin

(2019) Ali A. Almaqwashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

Pt(IV) Bifunctional Prodrug Containing 2-(2-Propynyl)octanoato Axial Ligand: Induction of Immunogenic Cell Death on Colon Cancer

(2019) Maurizio Sabbatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fuplatin: An Efficient and Low-Toxic Dual-Prodrug

(2019) Ran Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds

(2019) Stéphane Bellemin-Laponnaz   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression

(2019) Rong Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)-complexes with an L-alanyl-based ligand

(2019) Claudia Riccardi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

(2019) Victoria D. Turubanova et al.   Journal for ImmunoTherapy of Cancer

The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3

(2018) Wen Zhou et al.   CHEMICAL COMMUNICATIONS

Anticancer metal-N-heterocyclic carbene complexes of gold, platinum and palladium

(2018) Taotao Zou et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells

(2018) Feng-Yang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance

(2018) Xiang Ling et al.   NANO LETTERS

New Platinum(II) Agent Induces Bimodal Death of Apoptosis and Autophagy Against A549 Cancer Cell

(2018) Feng-Yang Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Integrating the Epigenome to Identify Novel Drivers of Hepatocellular Carcinoma

(2018) R A Hlady et al.   HEPATOLOGY

Stimuli-Responsive Therapeutic Metallodrugs

(2018) Xiaohui Wang et al.   CHEMICAL REVIEWS

PD-L1 microSPECT/CT Imaging for Longitudinal Monitoring of PD-L1 Expression in Syngeneic and Humanized Mouse Models for Cancer

(2018) Sandra Heskamp et al.   Cancer Immunology Research

Stimulus-responsive viral vectors for controlled delivery of therapeutics

(2017) Mitchell J. Brun et al.   JOURNAL OF CONTROLLED RELEASE

Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model

(2017) Guangfu Li et al.   JOURNAL OF HEPATOLOGY

A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research

(2017) Dorian M. Cheff et al.   JOURNAL OF MEDICINAL CHEMISTRY

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

(2017) Peter M Bruno et al.   NATURE MEDICINE

Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

(2016) Wukun Liu et al.   COORDINATION CHEMISTRY REVIEWS

Anticancer metal drugs and immunogenic cell death

(2016) Alessio Terenzi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, structural characterization and in vitro anti-cancer activity of functionalized N-heterocyclic carbene platinum and palladium complexes

(2015) Georges Dahm et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Trial Watch

(2014) Erika Vacchelli et al.   OncoImmunology

Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents

(2013) Taotao Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facing the dawn of immunotherapy for hepatocellular carcinoma

(2013) Martin F. Sprinzl et al.   JOURNAL OF HEPATOLOGY

Antitumor trans-N-Heterocyclic Carbene–Amine–Pt(II) Complexes: Synthesis of Dinuclear Species and Exploratory Investigations of DNA Binding and Cytotoxicity Mechanisms

(2013) Mélanie Chtchigrovsky et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2013) Latifa Bakiri et al.   Molecular Oncology

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

(2012) Carlo Schneider et al.   GUT

Synthesis, Characterization, and in Vitro Studies of Bis[1,3-diethyl-4,5-diarylimidazol-2-ylidene]gold(I/III) Complexes

(2012) Wukun Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma

(2011) E. J. Lipson et al.   CLINICAL CANCER RESEARCH

Synthesis and biological studies of silver N-heterocyclic carbene complexes derived from 4,5-diarylimidazole

(2011) Wukun Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NHC Gold Halide Complexes Derived from 4,5-Diarylimidazoles: Synthesis, Structural Analysis, and Pharmacological Investigations as Potential Antitumor Agents

(2011) Wukun Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential of immunotherapy for hepatocellular carcinoma

(2010) Ekaterina Breous et al.   JOURNAL OF HEPATOLOGY

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

(2008) Ogyi Park et al.   HEPATOLOGY