Mouse models for liver cancer

Conflicting Roles of Molecules in Hepatocarcinogenesis: Paradigm or Paradox

(2012) Gen-Sheng Feng   CANCER CELL

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Prospects for Prophylactic and Therapeutic Vaccines Against Hepatitis C Virus

(2012) Stephen M. Feinstone et al.   CLINICAL INFECTIOUS DISEASES

Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice

(2012) Gui Jie Feng et al.   GASTROENTEROLOGY

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis

(2012) Wen-Lung Ma et al.   HEPATOLOGY

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional role of peroxisome-proliferator-activated receptor γ in hepatocellular carcinoma

(2012) Chung-Wah Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Consumption of high-fat diet induces tumor progression and epithelial–mesenchymal transition of colorectal cancer in a mouse xenograft model

(2012) Feng-Yao Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans

(2012) Ann-Marie Mallon et al.   MAMMALIAN GENOME

The mammalian gene function resource: the international knockout mouse consortium

(2012) Allan Bradley et al.   MAMMALIAN GENOME

The changing therapeutic landscape for hepatitis C

(2012) Gregory J Dore   MEDICAL JOURNAL OF AUSTRALIA

Hepatocarcinogenesis in FXR−/−Mice Mimics Human HCC Progression That Operates through HNF1α Regulation of FXR Expression

(2012) Nian Liu et al.   MOLECULAR ENDOCRINOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

Genomic landscape of liver cancer

(2012) Zemin Zhang   NATURE GENETICS

Production of avian retroviruses and tissue-specific somatic retroviral gene transfer in vivo using the RCAS/TVA system

(2012) Alexander von Werder et al.   Nature Protocols

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis

(2012) Masahito Shimizu et al.   Seminars in Immunopathology

Animal models for the study of hepatitis C virus infection and replication

(2012) Kristin L MacArthur   WORLD JOURNAL OF GASTROENTEROLOGY

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

(2011) Prem K. Premsrirut et al.   CELL

Targeted Therapies for Hepatocellular Carcinoma

(2011) Augusto Villanueva et al.   GASTROENTEROLOGY

Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury

(2011) Tarek Moustafa et al.   GASTROENTEROLOGY

The role of JNK in the development of hepatocellular carcinoma

(2011) Madhumita Das et al.   GENES & DEVELOPMENT

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Combined Serum and Tissue Proteomic Study Applied to a c-Myc Transgenic Mouse Model of Hepatocellular Carcinoma Identified Novel Disease Regulated Proteins Suitable for Diagnosis and Therapeutic Intervention Strategies

(2011) Maria Stella Ritorto et al.   JOURNAL OF PROTEOME RESEARCH

Cre recombinase resources for conditional mouse mutagenesis

(2011) Damian Smedley et al.   METHODS

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

A resource of vectors and ES cells for targeted deletion of microRNAs in mice

(2011) Haydn M Prosser et al.   NATURE BIOTECHNOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Hepatocellular carcinoma: insight from animal models

(2011) Yan Li et al.   Nature Reviews Gastroenterology & Hepatology

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

(2011) D R McGivern et al.   ONCOGENE

Gene Signatures Derived from a c-MET-Driven Liver Cancer Mouse Model Predict Survival of Patients with Hepatocellular Carcinoma

(2011) Irena Ivanovska et al.   PLoS One

Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure

(2011) Hanno Ehlken et al.   PLoS One

Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis

(2010) Mahwish Khan et al.   ARCHIVES OF VIROLOGY

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models

(2010) D. K. Broz et al.   CARCINOGENESIS

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

The worldwide impact of vaccination on the control and protection of viral hepatitis B

(2010) Luisa Romano' et al.   DIGESTIVE AND LIVER DISEASE

Proteomic mining in the dysplastic liver of WHV/c-myc mice - insights and indicators for early hepatocarcinogenesis

(2010) Yansheng Liu et al.   FEBS Journal

Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and Inhibits Hepatocellular Carcinoma

(2010) Neeraj K. Saxena et al.   GASTROENTEROLOGY

Sorafenib: Where do we go from here?

(2010) Abby B. Siegel et al.   HEPATOLOGY

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair

(2010) Keigo Machida et al.   HEPATOLOGY

Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro

(2010) Jun Yu et al.   HEPATOLOGY

Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice

(2010) Kristina Aleksic et al.   HEPATOLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Animal model for study of human hepatitis viruses

(2010) Kazuaki Chayama et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage

(2010) Victoria Tovar et al.   JOURNAL OF HEPATOLOGY

Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old

(2010) Dilek Colak et al.   Molecular Cancer

Gender Disparity of Hepatocellular Carcinoma: The Roles of Sex Hormones

(2010) Shiou-Hwei Yeh et al.   ONCOLOGY

Stress and Sex Versus Immunity and Inflammation

(2010) G. P. Chrousos   Science Signaling

Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad

(2010) Kari Nichole Nejak-Bowen et al.   SEMINARS IN CANCER BIOLOGY

The Spectrum of Liver Diseases Related toABCB4Gene Mutations: Pathophysiology and Clinical Aspects

(2010) Anne Davit-Spraul et al.   SEMINARS IN LIVER DISEASE

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis

(2009) P. Kaposi-Novak et al.   CANCER RESEARCH

Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17

(2009) Stephanie E.-M. Peychal et al.   CARCINOGENESIS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Integrative oncogenomic approaches for accelerated cancer-gene discovery

(2009) Lars Zender et al.   CURRENT OPINION IN ONCOLOGY

Mouse Models of Human Cancers Consortium (MMHCC) from the NCI

(2009) C. Marks   Disease Models & Mechanisms

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens

(2009) J G Fox et al.   GUT

Diet-induced hepatocellular carcinoma in genetically predisposed mice

(2009) A. E. Hill-Baskin et al.   HUMAN MOLECULAR GENETICS

Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis

(2009) Takeharu Asano et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

Androgen Receptor Is a New Potential Therapeutic Target for the Treatment of Hepatocellular Carcinoma

(2008) Weng–Lung Ma et al.   GASTROENTEROLOGY

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

(2008) Kirk J. Wangensteen et al.   HEPATOLOGY

Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

(2008) Cédric Coulouarn et al.   HEPATOLOGY

Two-dimensional differential gel electrophoresis/analysis of diethylnitrosamine induced rat hepatocellular carcinoma

(2008) Yanting Qi et al.   INTERNATIONAL JOURNAL OF CANCER

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts

(2008) Martha R. Watson et al.   JOURNAL OF HEPATOLOGY

Experimental models of hepatocellular carcinoma

(2008) Philippa Newell et al.   JOURNAL OF HEPATOLOGY

Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma

(2008) Taro Yamashita et al.   JOURNAL OF HEPATOLOGY

Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment

(2008) C. Cheung et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

(2008) K. R. Reed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective

(2008) Mariana Lazo et al.   SEMINARS IN LIVER DISEASE

Role of sex steroid receptors in pathobiology of hepatocellular carcinoma

(2008) Mamta Kalra et al.   WORLD JOURNAL OF GASTROENTEROLOGY