Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

(2020) Jinyun Dong et al.   DRUG RESISTANCE UPDATES

Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells

(2020) Francesca Rolle et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

(2020) Lorenzo Galluzzi et al.   Journal for ImmunoTherapy of Cancer

Natural modulators of the hallmarks of immunogenic cell death

(2019) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Calreticulin in phagocytosis and cancer: opposite roles in immune response outcomes

(2019) Alejandro Schcolnik-Cabrera et al.   APOPTOSIS

An updated patent review on P-glycoprotein inhibitors (2011-2018)

(2019) Marcello Leopoldo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer

(2019) James W. Opzoomer et al.   Frontiers in Immunology

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers

(2019) Elisabetta Teodori et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

G-Quadruplex Binders Induce Immunogenic Cell Death Markers in Aggressive Breast Cancer Cells

(2019) Sarah Di Somma et al.   Cancers

Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

(2018) Lina Al-Akra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma

(2018) Joanna Kopecka et al.   LUNG CANCER

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

(2018) Ilaria Buondonno et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

(2018) Jessica Marinello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma

(2017) Keita Aoto et al.   ONCOLOGY REPORTS

A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway

(2016) A. M. S. Hartz et al.   JOURNAL OF NEUROSCIENCE

P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors

(2016) Joanna Kopecka et al.   Oncotarget

Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein

(2015) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

(2015) Margaret E. Tome et al.   JOURNAL OF NEUROCHEMISTRY

The Role of C/EBP-β LIP in Multidrug Resistance

(2015) Chiara Riganti et al.   JNCI-Journal of the National Cancer Institute

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

(2015) Joanna Kopecka et al.   Oncotarget

The Role of C/EBP-β LIP in Multidrug Resistance

(2015) Chiara Riganti et al.   JNCI-Journal of the National Cancer Institute

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists

(2013) T Yamazaki et al.   CELL DEATH AND DIFFERENTIATION

Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

(2013) Giada Gelsomino et al.   Molecular Cancer

Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition

(2013) Joanna Kopecka et al.   Nanomedicine-Nanotechnology Biology and Medicine

Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

(2013) Chiara Riganti et al.   PLoS One

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

(2013) Yuting Ma et al.   OncoImmunology

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

(2012) Mickaël Michaud et al.   OncoImmunology

H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein

(2010) Ning Wei et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells

(2010) Joanna Kopecka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure–Activity Relationships of Tariquidar Analogs as Multidrug Resistance Modulators

(2009) Ilza K. Pajeva et al.   AAPS Journal

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells

(2009) Sara De Boo et al.   Molecular Cancer

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE