An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer

HMGB1-induced ILC2s activate dendritic cells by producing IL-9 in mice asthma

(2020) Jie Wan et al.   CELLULAR IMMUNOLOGY

Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

(2020) Zhuo Yu et al.   ACS Nano

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

(2020) Zhiqin Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prodrug‐Based Versatile Nanomedicine for Enhancing Cancer Immunotherapy by Increasing Immunogenic Cell Death

(2020) Shuang Bai et al.   Small

Cell death induced by cytotoxic CD8+T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

(2020) Paula Jaime-Sanchez et al.   Journal for ImmunoTherapy of Cancer

Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma

(2020) Hiroaki Kinoh et al.   ACS Nano

MnO x Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

(2020) Binbin Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PlatinER: a Highly Potent Anticancer Platinum(II) Complex that induces Endoplasmic Reticulum Stress‐driven Immunogenic Cell Death

(2020) Max Jing Rui Tham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances of iridium(III) metallophosphors for health-related applications

(2020) Po-Yu Ho et al.   COORDINATION CHEMISTRY REVIEWS

Clinically Relevant Chemotherapeutics Have the Ability to Induce Immunogenic Cell Death in Non-Small Cell Lung Cancer

(2020) Tal Flieswasser et al.   Cells

Pt(IV) Bifunctional Prodrug Containing 2-(2-Propynyl)octanoato Axial Ligand: Induction of Immunogenic Cell Death on Colon Cancer

(2019) Maurizio Sabbatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted photoredox catalysis in cancer cells

(2019) Huaiyi Huang et al.   Nature Chemistry

Photothermal-Chemotherapy Integrated Nanoparticles with Tumor Microenvironment Response Enhanced the Induction of Immunogenic Cell Death for Colorectal Cancer Efficient Treatment

(2019) Yayu Wen et al.   ACS Applied Materials & Interfaces

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

(2019) Chao Chen et al.   ADVANCED MATERIALS

FerriIridium: A Lysosome-Targeting Iron(III)-Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells

(2019) Shi Kuang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy

(2018) Na Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

(2018) Samuel M. Meier-Menches et al.   CHEMICAL SOCIETY REVIEWS

Oncosis-inducing cyclometalated iridium(iii) complexes

(2018) Ruilin Guan et al.   Chemical Science

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

(2018) Martijn Kerkhofs et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Stimuli-Responsive Therapeutic Metallodrugs

(2018) Xiaohui Wang et al.   CHEMICAL REVIEWS

Metal Drugs and the Anticancer Immune Response

(2018) Bernhard Englinger et al.   CHEMICAL REVIEWS

Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16

(2018) Sanjeev Kumar Sagwal et al.   Cell Death & Disease

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Organelle-targeting metal complexes: From molecular design to bio-applications

(2017) Kangqiang Qiu et al.   COORDINATION CHEMISTRY REVIEWS

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma

(2016) Robert Z. Orlowski et al.   CANCER

Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial

(2016) William D Tap et al.   LANCET

Dexrazoxane improves cardiac autonomic function in epirubicin-treated breast cancer patients with type 2 diabetes

(2016) Fangyi Sun et al.   MEDICINE

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Multifunctional platinum-based nanoparticles for biomedical applications

(2016) Qinqin Cheng et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

eIF2α phosphorylation as a biomarker of immunogenic cell death

(2015) Oliver Kepp et al.   SEMINARS IN CANCER BIOLOGY

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

(2015) Abhishek D. Garg et al.   Oncotarget

Functionalization of cyclometalated iridium(iii) polypyridine complexes for the design of intracellular sensors, organelle-targeting imaging reagents, and metallodrugs

(2015) Kenneth Kam-Wing Lo et al.   Inorganic Chemistry Frontiers

Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: A large-scale meta-analysis

(2015) Abhishek D. Garg et al.   OncoImmunology

Survival, Efficacy, and Safety of Small Versus Large Doxorubicin Drug-Eluting Beads TACE Chemoembolization in Patients With Unresectable HCC

(2014) Hasmukh J. Prajapati et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma

(2014) Edwin Choy et al.   CANCER

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Long-term cardiac safety and outcomes of dose-dense doxorubicin and cyclophosphamide followed by paclitaxel and trastuzumab with and without lapatinib in patients with early breast cancer

(2013) Patrick G. Morris et al.   CANCER

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

5-Year Outcome of a Randomized Prospective Study Comparing bacillus Calmette-Guérin with Epirubicin and Interferon-α2b in Patients with T1 Bladder Cancer

(2013) Tammer Hemdan et al.   JOURNAL OF UROLOGY

Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE