Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 794, Issue -, Pages 115-124Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2015.07.003
Keywords
N-heterocyclic carbene; Palladium; Platinum
Categories
Funding
- CNRS
- Ministere de l'Enseignement Superieur et de la Recherche
- La Ligue contre le Cancer - Region Grand Est
Ask authors/readers for more resources
A series of platinum(II) and palladium(II) complexes bearing N-heterocyclic carbene ligands functionalized by specific functionalities such as alcohol, nitrile or ester were synthesized. The novel complexes were fully characterized and X-ray diffraction was used for the structure determination of eight derivatives. The reactivity of the functional groups has been studied; for example, Pt and Pd NHC complexes containing tBu ester functions were easily hydrolyzed giving water-soluble NHC complexes. The palladium complex 21 containing dangling COOH group was evaluated in copper-free Sonogashira coupling reaction. In addition, platinum NHC complexes are attractive metal-based systems for the development of anticancer drugs. Preliminary results of the biological effects on various human cancer and non-cancer cells are also reported. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available