N-Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds

Recent progress in silver(I)-, gold(I)/(III)- and palladium(II)-N-heterocyclic carbene complexes: A review towards biological perspectives

(2019) Sunusi Y. Hussaini et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction

(2019) Sébastien Harlepp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and structural characterization of benzyl-functionalized N-heterocyclic carbene platinum complexes: Dramatic substituent effect on anti-cancer activity

(2019) Georges Dahm et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Anticancer metal-N-heterocyclic carbene complexes of gold, platinum and palladium

(2018) Taotao Zou et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New insights in Au-NHCs complexes as anticancer agents

(2018) Marina Porchia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring diversity in platinum(iv) N-heterocyclic carbene complexes: synthesis, characterization, reactivity and biological evaluation

(2018) Mathilde Bouché et al.   DALTON TRANSACTIONS

N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact

(2018) May Wantz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, Structure and Antitumoural Activity of Triazole-Functionalised NHC-Metal Complexes

(2017) Marco Monticelli et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Synthesis and structural characterization of alkyne-functionalized N-heterocyclic carbene complexes of ruthenium, palladium and rhodium

(2017) Edith Chardon et al.   INORGANICA CHIMICA ACTA

N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy

(2016) Neila Chekkat et al.   BIOCONJUGATE CHEMISTRY

Linking of Antitumor trans NHC-Pt(II) Complexes to G-Quadruplex DNA Ligand for Telomeric Targeting

(2016) Jean-François Betzer et al.   BIOCONJUGATE CHEMISTRY

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

(2016) Wukun Liu et al.   COORDINATION CHEMISTRY REVIEWS

Platinum(iv) anticancer prodrugs – hypotheses and facts

(2016) Dan Gibson   DALTON TRANSACTIONS

Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity

(2016) M. Bouché et al.   DALTON TRANSACTIONS

The Platin-X series: activation, targeting, and delivery

(2016) Uttara Basu et al.   DALTON TRANSACTIONS

Selective Formation of cis-N-Heterocyclic Carbene-PtII-Pnictogen Complexes and in vitro Evaluation of Their Cytotoxic Activities toward Cancer Cells

(2016) Mathilde Bouché et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold

(2016) Florian Schmitt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Post-functionalization of platinum–NHC complexes by oxime ligation for ligand targeted therapy

(2016) Etienne Borré et al.   NEW JOURNAL OF CHEMISTRY

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

(2015) Oleksandr Koniev et al.   CHEMICAL SOCIETY REVIEWS

A Chemoselective and Modular Post-Synthetic Multi-Functionalization of NHC-Platinum Complexes

(2015) Georges Dahm et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group

(2015) Julienne K. Muenzner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structural characterization and in vitro anti-cancer activity of functionalized N-heterocyclic carbene platinum and palladium complexes

(2015) Georges Dahm et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Post-functionalization of metal–NHC complexes: A useful toolbox for bioorganometallic chemistry (and beyond)?

(2015) Federico Cisnetti et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

The divergent effects of strong NHC donation in catalysis

(2015) Justin A. M. Lummiss et al.   Chemical Science

Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture

(2015) Agla J. Fridriksdottir et al.   Nature Communications

Role of transporters in the distribution of platinum-based drugs

(2015) Saliha Harrach et al.   Frontiers in Pharmacology

Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents

(2014) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Group 1 and 2 and Early Transition Metal Complexes Bearing N-Heterocyclic Carbene Ligands: Coordination Chemistry, Reactivity, and Applications

(2014) Stéphane Bellemin-Laponnaz et al.   CHEMICAL REVIEWS

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

(2014) Wen Tang et al.   CHEMICAL SOCIETY REVIEWS

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

(2014) Craig S. McKay et al.   CHEMISTRY & BIOLOGY

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

(2014) Nasma D. Eljack et al.   Metallomics

Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin

(2014) Sarah Spreckelmeyer et al.   MOLECULES

Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid

(2013) Stijn M. Agten et al.   CHEMBIOCHEM

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

(2013) Prakasam Thirumurugan et al.   CHEMICAL REVIEWS

Exploring Nitrogen Ligand Diversity intrans-N-Heterocyclic Carbene-Amine Platinum Complexes : Synthesis, Characterization, and Application to Fluorescence

(2013) Edith Chardon et al.   Chemistry-An Asian Journal

Transition metal bioconjugates with an organometallic link between the metal and the biomolecular scaffold

(2013) Angèle Monney et al.   COORDINATION CHEMISTRY REVIEWS

Antitumor trans-N-Heterocyclic Carbene–Amine–Pt(II) Complexes: Synthesis of Dinuclear Species and Exploratory Investigations of DNA Binding and Cytotoxicity Mechanisms

(2013) Mélanie Chtchigrovsky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of liposomal formulations: From concept to clinical investigations

(2013) Yuchen Fan et al.   Asian Journal of Pharmaceutical Sciences

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

(2012) Wukun Liu et al.   CHEMICAL SOCIETY REVIEWS

Genetic polymorphism of copper transporter protein 1 is related to platinum resistance in Chinese non-small cell lung carcinoma patients

(2012) Xiaojing Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Harnessing chemoselective imine ligation for tethering bioactive molecules to platinum(iv) prodrugs

(2012) Daniel Yuan Qiang Wong et al.   DALTON TRANSACTIONS

Platinum(ii) and platinum(iv) complexes stabilized by abnormal/mesoionic C4-bound dicarbenes

(2012) Vsevolod Khlebnikov et al.   DALTON TRANSACTIONS

Au(i)- and Pt(ii)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures, electrochemistry and cytotoxicity studies

(2012) Sirsendu Das Adhikary et al.   NEW JOURNAL OF CHEMISTRY

CuAAC Functionalization of Azide-Tagged Copper(I)-NHCs Acting as Catalyst and Substrate

(2012) Clémentine Gibard et al.   ORGANOMETALLICS

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Derivatization of Preformed Platinum N-Heterocyclic Carbene Complexes with Amino Acid and Peptide Ligands and Cytotoxic Activities toward Human Cancer Cells

(2012) Edith Chardon et al.   ORGANOMETALLICS

Easy Derivatisation of Group 10 N-Heterocyclic Carbene Complexes and In Vitro Evaluation of an Anticancer Oestradiol Conjugate

(2012) Edith Chardon et al.   ChemPlusChem

Direct functionalisation of group 10 N-heterocyclic carbene complexes for diversity enhancement

(2011) Edith Chardon et al.   CHEMICAL COMMUNICATIONS

Synthetic Routes to N-Heterocyclic Carbene Precursors

(2011) Laure Benhamou et al.   CHEMICAL REVIEWS

Advances in metal–carbene complexes as potent anti-cancer agents

(2011) Arnaud Gautier et al.   Metallomics

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

Bringing chemistry to life

(2011) Michael Boyce et al.   NATURE METHODS

Acetal-Functionalized RAPTA Complexes for Conjugation and Labeling

(2011) Yu Qian Tan et al.   ORGANOMETALLICS

One-step synthesis of composite vesicles: Direct polymerization and in situ over-oxidation of thiophene

(2011) Hang Sun et al.   Chemical Science

Selectively targeting estrogen receptors for cancer treatment

(2010) Erin K. Shanle et al.   ADVANCED DRUG DELIVERY REVIEWS

Beyond catalysis: N-heterocyclic carbene complexes as components for medicinal, luminescent, and functional materials applications

(2010) Laszlo Mercs et al.   CHEMICAL SOCIETY REVIEWS

New frontiers in protein bioconjugation

(2010) Matthew B Francis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

N-heterocyclic carbene tethered amido complexes of palladium and platinum

(2010) Warren B. Cross et al.   DALTON TRANSACTIONS

Novel platinum-N-heterocyclic carbene complex is more cardiotoxic than cis-platin in rats

(2010) Osman Ciftci et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

(2010) Myriem Skander et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Platinum(IV) Complexes with Chelating N-Heterocyclic Carbene Ligands

(2010) Dirk Meyer et al.   ORGANOMETALLICS

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Satraplatin: leading the new generation of oral platinum agents

(2009) Ashish Bhargava et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Platinum(II) Catalysts for Highly Enantioselective 1,6-Enyne Cycloisomerizations. Synthetic, Structural, and Catalytic Studies

(2009) Delphine Brissy et al.   ORGANIC LETTERS

Hydrolytic Stability of Hydrazones and Oximes

(2008) Jeet Kalia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Ruthenium-Catalyzed Azide−Alkyne Cycloaddition: Scope and Mechanism

(2008) Brant C. Boren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paul Ehrlich: founder of chemotherapy

(2008) Stefan H. E. Kaufmann   NATURE REVIEWS DRUG DISCOVERY

Platinum(II) Complexes Featuring Chiral Diphosphines and N-Heterocyclic Carbene Ligands: Synthesis and Evaluation as Cycloisomerization Catalysts

(2008) Delphine Brissy et al.   ORGANOMETALLICS

Systemic Delivery of DNA or siRNA Mediated by Linear Polyethylenimine (L-PEI) Does Not Induce an Inflammatory Response

(2008) Marie-Elise Bonnet et al.   PHARMACEUTICAL RESEARCH