Structural basis of the super- and hyper-relaxed states of myosin II

Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing

(2021) Marco Caremani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms

(2021) Weikang Ma et al.   JOURNAL OF GENERAL PHYSIOLOGY

To lie or not to lie: Super-relaxing with myosins

(2021) Suman Nag et al.   eLife

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

(2021) Manuel Schmid et al.   Biology Open

Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine

(2021) Matthew J. Daniels et al.   CIRCULATION

The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium

(2021) Weikang Ma et al.   CIRCULATION RESEARCH

Molecular-scale visualization of sarcomere contraction within native cardiomyocytes

(2021) Laura Burbaum et al.   Nature Communications

Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States

(2021) Sampath K. Gollapudi et al.   JOURNAL OF MOLECULAR BIOLOGY

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

(2020) Christopher N. Toepfer et al.   CIRCULATION

The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches

(2020) Darshan V. Trivedi et al.   Annual Review of Biochemistry

Hummingbird torpor in context: duration, more than temperature, is the key to nighttime energy savings

(2020) Anusha Shankar et al.   JOURNAL OF AVIAN BIOLOGY

Myosin filament-based regulation of the dynamics of contraction in heart muscle

(2020) Elisabetta Brunello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms

(2020) Raúl Padrón et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

(2020) Saswata S. Sarkar et al.   Science Advances

Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent

(2020) Lien A. Phung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An extreme cold event leads to community-wide convergence in lower temperature tolerance in a lizard community

(2020) James T. Stroud et al.   Biology Letters

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

(2020) Shane R. Nelson et al.   BIOPHYSICAL JOURNAL

Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, disease, and mavacamten-treated cardiac systems

(2020) Sampath K. Gollapudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the shutdown state of myosin-2

(2020) Charlotte A. Scarff et al.   NATURE

Cryo-EM structure of the inhibited (10S) form of myosin II

(2020) Shixin Yang et al.   NATURE

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

(2019) Christopher N. Toepfer et al.   Science Translational Medicine

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2019) James A. Spudich   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Getting into the thick (and thin) of it

(2019) Thomas C. Irving et al.   JOURNAL OF GENERAL PHYSIOLOGY

Response to: Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components

(2019) Weikang Ma et al.   BIOPHYSICAL JOURNAL

Myosin: Formation and maintenance of thick filaments

(2019) Koichi Ojima   ANIMAL SCIENCE JOURNAL

Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies

(2019) Raquel Yotti et al.   Annual Review of Genomics and Human Genetics

Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

(2019) James W. McNamara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

(2019) Arjun S. Adhikari et al.   Nature Communications

The central role of the tail in switching off 10S myosin II activity

(2019) Shixin Yang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation

(2019) Marco Caremani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

(2018) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inotropic interventions do not change the resting state of myosin motors during cardiac diastole

(2018) Marco Caremani et al.   JOURNAL OF GENERAL PHYSIOLOGY

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

(2017) Robert W. Kensler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

X-ray diffraction analysis of the effects of myosin regulatory light chain phosphorylation and butanedione monoxime on skinned skeletal muscle fibers

(2016) Maki Yamaguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

(2016) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

An approach to improve the resolution of helical filaments with a large axial rise and flexible subunits

(2016) Shixin Yang et al.   JOURNAL OF STRUCTURAL BIOLOGY

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 A resolution

(2016) Z. Hu et al.   Science Advances

The Conformation of Myosin Heads in Relaxed Skeletal Muscle: Implications for Myosin-Based Regulation

(2015) Luca Fusi et al.   BIOPHYSICAL JOURNAL

Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chainin Vivo

(2015) Audrey N. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

(2015) Marco Linari et al.   NATURE

An invertebrate smooth muscle with striated muscle myosin filaments

(2015) Guidenn Sulbarán et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle

(2014) Clyde Wilson et al.   BIOPHYSICAL JOURNAL

Rapid short-term cooling following the Chicxulub impact at the Cretaceous-Paleogene boundary

(2014) J. Vellekoop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Head Environments in Tarantula Thick Filaments Support a Cooperative Activation Process

(2013) Guidenn Sulbarán et al.   BIOPHYSICAL JOURNAL

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

(2013) Christopher Toepfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications

(2013) J. L. Woodhead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin interacting-heads motif is present in the relaxed thick filament of the striated muscle of scorpion

(2012) Antonio Pinto et al.   JOURNAL OF STRUCTURAL BIOLOGY

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments

(2012) M. J. Previs et al.   SCIENCE

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy

(2011) Houman Ashrafian et al.   CIRCULATION RESEARCH

A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments

(2011) Reicy Brito et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Stabilization of Helical Order in the Thick Filaments by Blebbistatin: Further Evidence of Coexisting Multiple Conformations of Myosin

(2009) Sengen Xu et al.   BIOPHYSICAL JOURNAL

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

(2008) Fa-Qing Zhao et al.   BIOPHYSICAL JOURNAL

Understanding the Organisation and Role of Myosin Binding Protein C in Normal Striated Muscle by Comparison with MyBP-C Knockout Cardiac Muscle

(2008) Pradeep K. Luther et al.   JOURNAL OF MOLECULAR BIOLOGY

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Head–Head Interaction Characterizes the Relaxed State of Limulus Muscle Myosin Filaments

(2008) Fa-Qing Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA