The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium

To lie or not to lie: Super-relaxing with myosins

(2021) Suman Nag et al.   eLife

Myosin filament-based regulation of the dynamics of contraction in heart muscle

(2020) Elisabetta Brunello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts

(2020) Kerry S. McDonald et al.   Frontiers in Physiology

Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial

(2020) Adriaan A. Voors et al.   EUROPEAN JOURNAL OF HEART FAILURE

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

(2020) Shane R. Nelson et al.   BIOPHYSICAL JOURNAL

Effects of mavacamten on Ca 2+ sensitivity of contraction as sarcomere length varied in human myocardium

(2020) Peter O. Awinda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2019) James A. Spudich   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Getting into the thick (and thin) of it

(2019) Thomas C. Irving et al.   JOURNAL OF GENERAL PHYSIOLOGY

Force-dependent recruitment from the myosin OFF state contributes to length-dependent activation

(2018) Kenneth S. Campbell et al.   BIOPHYSICAL JOURNAL

Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task

(2018) Gabriella Piazzesi et al.   Frontiers in Physiology

Thick-Filament Extensibility in Intact Skeletal Muscle

(2018) Weikang Ma et al.   BIOPHYSICAL JOURNAL

Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle

(2018) Weikang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inotropic interventions do not change the resting state of myosin motors during cardiac diastole

(2018) Marco Caremani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes

(2017) Rajiv Sankaranarayanan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Myosin filament activation in the heart is tuned to the mechanical task

(2017) Massimo Reconditi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

(2016) Younss Ait-Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic role of ADP and Ca2+in diastolic myocardial stiffness

(2015) Vasco Sequeira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

(2015) Marco Linari et al.   NATURE

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-Bridge Lifetime

(2011) Bradley M. Palmer et al.   BIOPHYSICAL JOURNAL

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

Titin based viscosity in ventricular physiology: An integrative investigation of PEVK–actin interactions

(2011) Charles S. Chung et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myofilament length dependent activation

(2010) Pieter P. de Tombe et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA