Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States

Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms

(2021) Weikang Ma et al.   JOURNAL OF GENERAL PHYSIOLOGY

To lie or not to lie: Super-relaxing with myosins

(2021) Suman Nag et al.   eLife

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations

(2020) Alexander J Sparrow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches

(2020) Darshan V. Trivedi et al.   Annual Review of Biochemistry

The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms

(2020) Raúl Padrón et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

(2020) Saswata S. Sarkar et al.   Science Advances

Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy

(2020) Carolyn Y. Ho et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

(2020) Shane R. Nelson et al.   BIOPHYSICAL JOURNAL

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Iacopo Olivotto et al.   LANCET

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

(2019) Christopher N. Toepfer et al.   Science Translational Medicine

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2019) James A. Spudich   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy

(2019) Stephen B. Heitner et al.   ANNALS OF INTERNAL MEDICINE

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

(2019) Arjun S. Adhikari et al.   Nature Communications

228Long-term safety and effectiveness of mavacamten in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients (pts): update from PIONEER open-label extension (PIONEER-OLE) study

(2019) A Wang et al.   EUROPEAN HEART JOURNAL

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

(2018) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle

(2018) Weikang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential

(2018) Anna Á. Rauscher et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

(2018) Julien Robert-Paganin et al.   Nature Communications

Impact of the Myosin Modulator Mavacamten on Force Generation and Cross‐Bridge Behavior in a Murine Model of Hypercontractility

(2018) Ranganath Mamidi et al.   Journal of the American Heart Association

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

(2017) Raja F. Kawas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

(2017) Thomas Kampourakis et al.   JOURNAL OF PHYSIOLOGY-LONDON

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels

(2017) Wanjian Tang et al.   Frontiers in Physiology

2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update

(2017) Jill Trewhella et al.   Acta Crystallographica Section D-Structural Biology

BioXTAS RAW: improvements to a free open-source program for small-angle X-ray scattering data reduction and analysis

(2017) Jesse Bennett Hopkins et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

(2017) D. Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

(2016) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

(2016) Arjun S. Adhikari et al.   Cell Reports

Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 A resolution

(2016) Z. Hu et al.   Science Advances

A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

(2016) Joshua A. Stern et al.   PLoS One

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

para-Nitroblebbistatin, the Non-Cytotoxic and Photostable Myosin II Inhibitor

(2014) Miklós Képiró et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle

(2014) Clyde Wilson et al.   BIOPHYSICAL JOURNAL

X-Ray Solution Scattering of Squid Heavy Meromyosin: Strengthening the Evidence for an Ancient Compact off State

(2013) Richard E. Gillilan et al.   PLoS One

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke

(2010) B. Takacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of Helical Order in the Thick Filaments by Blebbistatin: Further Evidence of Coexisting Multiple Conformations of Myosin

(2009) Sengen Xu et al.   BIOPHYSICAL JOURNAL

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

(2008) Fa-Qing Zhao et al.   BIOPHYSICAL JOURNAL

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution

(2008) H. S. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA