The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

(2019) Christopher N. Toepfer et al.   Science Translational Medicine

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2019) James A. Spudich   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

(2019) James W. McNamara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

(2019) Arjun S. Adhikari et al.   Nature Communications

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level

(2018) Chao Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

(2018) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level

(2018) Chao Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke

(2018) Michael S. Woody et al.   Nature Communications

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

(2018) Julien Robert-Paganin et al.   Nature Communications

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

(2017) Thomas Kampourakis et al.   JOURNAL OF PHYSIOLOGY-LONDON

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

20 years of the SMART protein domain annotation resource

(2017) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

(2017) Masataka Kawana et al.   Science Advances

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

(2016) Julian R. Homburger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

(2016) Arjun S. Adhikari et al.   Cell Reports

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy

(2015) Christopher Semsarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

(2015) Tural Aksel et al.   Cell Reports

Contractility parameters of human  -cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

(2015) S. Nag et al.   Science Advances

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Structure and Interactions of Myosin-binding Protein C Domain C0

(2011) Joyce Ratti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular mechanisms of cardiomyopathy

(2011) Pamela A. Harvey et al.   JOURNAL OF CELL BIOLOGY

Genetics of hypertrophic cardiomyopathy

(2010) Tetsuo Konno et al.   CURRENT OPINION IN CARDIOLOGY

Binding of the N-terminal fragment C0–C2 of cardiac MyBP-C to cardiac F-actin

(2010) Robert W. Kensler et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner

(2009) Justin F. Shaffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA