A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity

(2015) Ahmed A. Alfares et al.   GENETICS IN MEDICINE

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

(2015) Tural Aksel et al.   Cell Reports

Contractility parameters of human  -cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

(2015) S. Nag et al.   Science Advances

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

(2014) Danos C. Christodoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of mechanical stress on fibroblast–myocyte interactions in mammalian heart

(2014) Denis V. Abramochkin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Characterization of a Phenotype-Based Genetic Test Prediction Score for Unrelated Patients With Hypertrophic Cardiomyopathy

(2014) J. Martijn Bos et al.   MAYO CLINIC PROCEEDINGS

Early Changes in Apical Rotation in Genotype Positive Children with Hypertrophic Cardiomyopathy Mutations without Hypertrophic Changes on Two-Dimensional Imaging

(2013) Jonathan Forsey et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Constitutive Modeling of Mouse Carotid Arteries Using Experimentally Measured Microstructural Parameters

(2012) William Wan et al.   BIOPHYSICAL JOURNAL

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

(2012) Roberto Spoladore et al.   EUROPEAN HEART JOURNAL

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

(2010) Polakit Teekakirikul et al.   JOURNAL OF CLINICAL INVESTIGATION