To lie or not to lie: Super-relaxing with myosins

Modumodulation by Inotropic Interventions of the Regulatory State of the Cardiac Thick Filament in Diastole

(2020) Marco Caremani et al.   BIOPHYSICAL JOURNAL

Decoupling the Interacting Head Motif and the Super Relaxed State of Myosin in Reconstituted Cardiac Bipolar Thick Filaments

(2020) Sampath K. Gollapudi et al.   BIOPHYSICAL JOURNAL

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

(2020) Christopher N. Toepfer et al.   CIRCULATION

Ablation of the N terminus of cardiac essential light chain promotes the super‐relaxed state of myosin and counteracts hypercontractility in hypertrophic cardiomyopathy mutant mice

(2020) Yoel H. Sitbon et al.   FEBS Journal

Myosin filament-based regulation of the dynamics of contraction in heart muscle

(2020) Elisabetta Brunello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

(2020) Saswata S. Sarkar et al.   Science Advances

Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent

(2020) Lien A. Phung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

(2020) Shane R. Nelson et al.   BIOPHYSICAL JOURNAL

Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, disease, and mavacamten-treated cardiac systems

(2020) Sampath K. Gollapudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the shutdown state of myosin-2

(2020) Charlotte A. Scarff et al.   NATURE

Cryo-EM structure of the inhibited (10S) form of myosin II

(2020) Shixin Yang et al.   NATURE

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

(2019) Christopher N. Toepfer et al.   Science Translational Medicine

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2019) James A. Spudich   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

(2019) James W. McNamara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation

(2019) Marco Caremani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Abstract 340: Myosin Regulatory Light Chain: A Major Player in Defining the ‘OFF’ State of Cardiac Myosin

(2019) Na Sa et al.   CIRCULATION RESEARCH

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

(2018) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

(2018) Kyoung Hwan Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thick-Filament Extensibility in Intact Skeletal Muscle

(2018) Weikang Ma et al.   BIOPHYSICAL JOURNAL

Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle

(2018) Weikang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice

(2018) Lien A. Phung et al.   PLoS One

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piperine, an alkaloid inhibiting the super-relaxed state of myosin, binds to the myosin regulatory light chain

(2018) Dmitri Tolkatchev et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phosphomimetic-mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain

(2018) Sunil Yadav et al.   FEBS Journal

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

(2017) Thomas Kampourakis et al.   JOURNAL OF PHYSIOLOGY-LONDON

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

(2017) Vicente J. Planelles-Herrero et al.   Nature Communications

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives

(2016) Haiyang Yu et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

(2016) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle

(2016) Leonardo Nogara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

(2016) Julian R. Homburger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle

(2016) Leonardo Nogara et al.   PLoS One

The myosin super-relaxed state is disrupted by estradiol deficiency

(2015) Brett A. Colson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Conformation of Myosin Heads in Relaxed Skeletal Muscle: Implications for Myosin-Based Regulation

(2015) Luca Fusi et al.   BIOPHYSICAL JOURNAL

Genetic advances in sarcomeric cardiomyopathies: state of the art

(2015) C. Y. Ho et al.   CARDIOVASCULAR RESEARCH

Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain

(2015) Piyali Guhathakurta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle

(2014) Clyde Wilson et al.   BIOPHYSICAL JOURNAL

Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats

(2014) Parim BrahmaNaidu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice

(2013) Seoyoon Choi et al.   FOOD CHEMISTRY

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

(2013) Christopher Toepfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications

(2013) J. L. Woodhead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin superfamily at a glance

(2012) M. A. Hartman et al.   JOURNAL OF CELL SCIENCE

Piperidine alkaloids from Piper retrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase

(2011) Kyung Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction

(2011) Priya Muthu et al.   FASEB JOURNAL

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Stabilization of Helical Order in the Thick Filaments by Blebbistatin: Further Evidence of Coexisting Multiple Conformations of Myosin

(2009) Sengen Xu et al.   BIOPHYSICAL JOURNAL

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice

(2009) Theodore P. Abraham et al.   CARDIOVASCULAR RESEARCH

The Role of the N-Terminus of the Myosin Essential Light Chain in Cardiac Muscle Contraction

(2009) Katarzyna Kazmierczak et al.   JOURNAL OF MOLECULAR BIOLOGY

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

(2008) Fa-Qing Zhao et al.   BIOPHYSICAL JOURNAL

Myosin Regulatory Light Chain Phosphorylation Attenuates Cardiac Hypertrophy

(2008) Jian Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution

(2008) H. S. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA