Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery

Poly(β-amino ester)-co -poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo

(2018) Umberto Capasso Palmiero et al.   Advanced Healthcare Materials

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

(2018) Kevin J. Kauffman et al.   Molecular Therapy-Nucleic Acids

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA

(2017) Siddharth Patel et al.   NANO LETTERS

Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions

(2017) Jacob S. Brenner et al.   Nanomedicine-Nanotechnology Biology and Medicine

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

(2017) Hao Yin et al.   NATURE BIOTECHNOLOGY

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

(2017) Christiane R Stadler et al.   NATURE MEDICINE

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

(2016) James C. Kaczmarek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures

(2016) Héloïse Ragelle et al.   Expert Opinion on Drug Delivery

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system

(2016) F DeRosa et al.   GENE THERAPY

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress towards the Synthesis of Amino Polyesters via Ring-Opening Polymerization (ROP) of Functional Lactones

(2016) Daniel Siegwart et al.   SYNLETT

Combinatorial Approach to Nanoarchitectonics for Nonviral Delivery of Nucleic Acids

(2015) Mijanur Rahaman Molla et al.   ADVANCED MATERIALS

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

(2015) Jing Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

(2015) Azita J Mahiny et al.   NATURE BIOTECHNOLOGY

Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers

(2015) Martin P. Stewart et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

(2014) Omar F. Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension

(2014) Michael G. Dickinson et al.   CARDIOVASCULAR RESEARCH

Organocatalytic Ring-Opening Polymerization of Morpholinones: New Strategies to Functionalized Polyesters

(2014) Timothy R. Blake et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae

(2014) J. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis

(2013) Zia ur Rehman et al.   ACS Nano

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

(2012) Ahmed A. Eltoukhy et al.   BIOMATERIALS

How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances

(2012) Zia ur Rehman et al.   JOURNAL OF CONTROLLED RELEASE

Targeted siRNA delivery to diseased microvascular endothelial cells-Cellular and molecular concepts

(2011) Piotr S. Kowalski et al.   IUBMB LIFE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

(2011) Jiangbing Zhou et al.   NATURE MATERIALS

Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

(2011) Huayu Tian et al.   PROGRESS IN POLYMER SCIENCE

Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): The first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction

(2010) Monica Taljaard et al.   AMERICAN HEART JOURNAL

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis

(2009) Janie L. Baratta et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

(2008) Jordan J. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆

(2008) C JEROME et al.   ADVANCED DRUG DELIVERY REVIEWS