Stress-responsive regulation of extracellular proteostasis

Endoplasmic Reticulum-Associated Biomarkers for Molecular Phenotyping of Rare Kidney Disease

(2021) Chuang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction

(2021) Xin Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis

(2021) Sandeep Satapathy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion

(2021) Bibiana Rius et al.   Blood Advances

Progranulin in Neurodegenerative Dementia

(2021) Xiao‐Ming Wang et al.   JOURNAL OF NEUROCHEMISTRY

Acute-phase protein synthesis: a key feature of innate immune functions of the liver

(2021) Christian Ehlting et al.   BIOLOGICAL CHEMISTRY

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology

(2021) M. Mahafuzur Rahman et al.   Molecular Neurodegeneration

Expanding the Family of Extracellular Chaperones: Identification of Human Plasma Proteins with Chaperone Activity

(2021) Nicholas J Geraghty et al.   PROTEIN SCIENCE

Identifying new molecular players in extracellular proteostasis

(2021) Sandeep Satapathy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Endoplasmic Reticulum Chaperones in Viral Infection: Therapeutic Perspectives

(2021) Evelyne Kohli et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

(2021) Jennifer West et al.   Science Advances

Heparan sulfate is a clearance receptor for aberrant extracellular proteins

(2020) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease

(2020) Nihad Tousson-Abouelazm et al.   LABORATORY INVESTIGATION

The Positive Side of the Alzheimer’s Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1

(2020) Lidia Ciccone et al.   MOLECULES

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-to-Cell Transmission of Tau and α-Synuclein

(2020) Norihito Uemura et al.   TRENDS IN MOLECULAR MEDICINE

Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease

(2020) Isabelle C. Romine et al.   BIOCHEMICAL JOURNAL

Role of S100 proteins in health and disease

(2020) Laura L. Gonzalez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increased expression and retention of the secretory chaperone proSAAS following cell stress

(2020) Manita Shakya et al.   CELL STRESS & CHAPERONES

The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin

(2020) Qin Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular proteostasis prevents aggregation during pathogenic attack

(2020) Ivan Gallotta et al.   NATURE

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

(2020) Julia M. D. Grandjean et al.   Nature Chemical Biology

Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

(2020) Richard M. Giadone et al.   Stem Cell Reports

Trophic activities of endoplasmic reticulum proteins CDNF and MANF

(2020) Maria Jӓntti et al.   CELL AND TISSUE RESEARCH

Secreted Chaperones in Neurodegeneration

(2020) Kriti Chaplot et al.   Frontiers in Aging Neuroscience

ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart

(2020) Bianca A. Meyer et al.   Cells

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

(2019) Isabelle C. Romine et al.   Scientific Reports

Mild heat stress induces transcription of the β‐casein gene via unfolded protein response‐activated XBP1 signaling in undifferentiated mammary epithelial cells

(2019) Moeko Mizusawa et al.   ANIMAL SCIENCE JOURNAL

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

Causes of AA amyloidosis: a systematic review

(2019) Anne Floor Brunger et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein

(2019) Ken Hanafusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aging and Alzheimer's disease pathology

(2019) Renpei Sengoku   NEUROPATHOLOGY

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway

(2018) Daniel Hughes et al.   FEBS Journal

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

(2018) Carrie R. Sowers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates

(2018) Lina Nilsson et al.   JOURNAL OF MOLECULAR BIOLOGY

A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease

(2018) Yannis Gerakis et al.   NEUROBIOLOGY OF AGING

PERK-mediated translational control is required for collagen secretion in chondrocytes

(2018) Satoshi Hisanaga et al.   Scientific Reports

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

(2018) Ryan Paxman et al.   eLife

Short-term administration of iso-α-acids increases transthyretin transcription in the hippocampus

(2018) Takafumi Fukuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HSF1 as a Cancer Biomarker and Therapeutic Target

(2018) Richard L. Carpenter et al.   CURRENT CANCER DRUG TARGETS

The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends

(2018) Kristine Faye R. Pobre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the ER stress-response protein PERK in rhodopsin retinitis pigmentosa

(2017) Dimitra Athanasiou et al.   HUMAN MOLECULAR GENETICS

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of curli assembly andEscherichia colibiofilm formation by the human systemic amyloid precursor transthyretin

(2017) Neha Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

(2017) Joseph D. Schonhoft et al.   Science Translational Medicine

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

(2017) Lars Plate et al.   TRENDS IN CELL BIOLOGY

Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System

(2017) Joel N. Buxbaum et al.   Frontiers in Neuroscience

Clusterin protects neurons against intracellular proteotoxicity

(2017) Jenna M. Gregory et al.   Acta Neuropathologica Communications

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

(2016) Michelle C. Bell et al.   Current Alzheimer Research

Polymers of Z α1-antitrypsin are secreted in cell models of disease

(2016) Annamaria Fra et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic amyloidosis

(2016) Ashutosh D Wechalekar et al.   LANCET

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

(2016) Payam Emami Khoonsari et al.   PLoS One

Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling

(2016) Joo Yeun Lee et al.   PLoS Genetics

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

(2016) Lars Plate et al.   eLife

Amyloidogenic lysozymes accumulate in the endoplasmic reticulum accompanied by the augmentation of ER stress signals

(2015) Yoshiki Kamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

(2014) Lisa M. Ryno et al.   ACS Chemical Biology

ERdj3 Is an Endoplasmic Reticulum Degradation Factor for Mutant Glucocerebrosidase Variants Linked to Gaucher’s Disease

(2014) Yun Lei Tan et al.   CHEMISTRY & BIOLOGY

ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein

(2014) John J. Chen et al.   CHEMISTRY & BIOLOGY

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis

(2014) J. C. Genereux et al.   EMBO JOURNAL

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

The Systemic Amyloid Precursor Transthyretin (TTR) Behaves as a Neuronal Stress Protein Regulated by HSF1 in SH-SY5Y Human Neuroblastoma Cells and APP23 Alzheimer's Disease Model Mice

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Mesencephalic astrocyte-derived neurotrophic factor prevents neuron loss via inhibiting ischemia-induced apoptosis

(2014) Wen Yang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

(2014) C. B. Cooley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

(2014) Fan Zhang et al.   Nature Communications

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

Systemic Amyloidoses

(2013) Luis M. Blancas-Mejía et al.   Annual Review of Biochemistry

Age-Related Oxidative Modifications of Transthyretin Modulate Its Amyloidogenicity

(2013) Lei Zhao et al.   BIOCHEMISTRY

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Protogenin prevents premature apoptosis of rostral cephalic neural crest cells by activating the α5β1-integrin

(2013) Y-C Wang et al.   Cell Death & Disease

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

The heat shock response in FAP: the role of the extracellular chaperone clusterin

(2012) Joana Magalhães et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Why are some amyloidoses systemic? Does hepatic “chaperoning at a distance” prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis?

(2012) Joel N. Buxbaum et al.   FASEB JOURNAL

Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion

(2012) Christopher C. Glembotski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Extracellular Chaperones in Amyloidosis

(2012) Amy R. Wyatt et al.   JOURNAL OF MOLECULAR BIOLOGY

GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer

(2012) N Li et al.   ONCOGENE

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activating Transcription Factor 6 Limits Intracellular Accumulation of Mutant α1-Antitrypsin Z and Mitochondrial Damage in Hepatoma Cells

(2011) Steven E. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin and COMMD1 Independently Regulate Degradation of the Mammalian Copper ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Production of Transthyretin in Human and Murine Alzheimer's Disease: Is It Protective?

(2011) X. Li et al.   JOURNAL OF NEUROSCIENCE

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

(2011) Daniel W. Neef et al.   NATURE REVIEWS DRUG DISCOVERY

Protogenin Defines a Transition Stage during Embryonic Neurogenesis and Prevents Precocious Neuronal Differentiation

(2010) Y.-H. Wong et al.   JOURNAL OF NEUROSCIENCE

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

(2010) Daniel W. Neef et al.   PLOS BIOLOGY

Interaction and functional association of protein disulfide isomerase with αVβ3 integrin on endothelial cells

(2008) Maria Swiatkowska et al.   FEBS Journal

A critical role for extracellular protein disulfide isomerase during thrombus formation in mice

(2008) Jaehyung Cho et al.   JOURNAL OF CLINICAL INVESTIGATION