Article
Cell Biology
Ruru Wang, Yajing Shang, Bin Chen, Feng Xu, Jie Zhang, Zhaoyang Zhang, Xipeng Zhao, Xiangbo Wan, An Xu, Lijun Wu, Guoping Zhao
Summary: This study found that high expression of PDI increases the risk of metastasis and poor prognosis in colorectal cancer tumors. PDI regulates autophagy signaling to inhibit cell death induced by radiotherapy/chemotherapy. Additionally, PDI interacts with the mitophagy receptor PHB2 in the mitochondria, inhibiting mitophagy signaling.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Valerie Perea, Christian Cole, Justine Lebeau, Vivian Dolina, Kelsey R. Baron, Aparajita Madhavan, Jeffery W. Kelly, Danielle A. Grotjahn, R. Luke Wiseman
Summary: Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are interconnected in the development of various diseases. The PERK signaling pathway, an arm of the unfolded protein response (UPR), plays a significant role in regulating mitochondrial biology during ER stress. This study reveals that PERK activity promotes adaptive remodeling of mitochondrial membrane phosphatidic acid (PA), leading to protective mitochondrial elongation in response to acute ER stress. These findings highlight a novel role for PERK in modulating mitochondrial phospholipids and demonstrate its involvement in adapting organellar shape during ER stress.
Article
Parasitology
Cudjoe Obed, Minmin Wu, Ying Chen, Ran An, Haijian Cai, Qingli Luo, Li Yu, Jie Wang, Fang Liu, Jilong Shen, Jian Du
Summary: Toxoplasma infection can cause ER stress and apoptosis in host cells. The dense granule protein GRA3 plays a role in the virulence of T. gondii, and it induces neural cell apoptosis via the ER stress signaling pathway.
PARASITES & VECTORS
(2022)
Article
Cell Biology
Killian Chaumonnot, Sophie Masson, Hugo Sikner, Alexanne Bouchard, Valentin Baverel, Pierre-Simon Bellaye, Bertrand Collin, Carmen Garrido, Evelyne Kohli
Summary: GRP94, an ER stress protein with dual inflammatory functions, is co-secreted with C3 under ER stress conditions in macrophages, contributing to the pro-inflammatory profile observed in stressed cells.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Lingai Pan, Dongke Yu, Yuan Zhang, Changyu Zhu, Qinan Yin, Yu Hu, Xiaoqin Zhang, Ruiming Yue, Xuan Xiong
Summary: The study shows that PS microplastics can induce ER stress in the liver, leading to apoptosis and oxidative stress in hepatocytes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Cell Biology
Qingyang Shi, Jiahuan Chen, Xiaodong Zou, Xiaochun Tang
Summary: Cholesterol homeostasis is important in understanding various diseases, and this review focuses on cholesterol synthesis, regulation, trafficking, and the role of lipid transfer proteins at organelle contact sites.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Ophthalmology
Shuizhen Shi, Chun Ding, Shuang Zhu, Fan Xia, Seth E. Buscho, Shengguo Li, Massoud Motamedi, Hua Liu, Wenbo Zhang
Summary: In this study, the role of PERK in ischemia-induced retinopathy was investigated using a mouse model of oxygen-induced retinopathy (OIR). The results showed that inhibition of PERK reduced retinal neovascularization and retinal ganglion cell loss, restored astrocyte network, and promoted revascularization. Therefore, PERK inhibition may provide an effective therapeutic intervention for alleviating retinal neovascularization and preventing neuron loss during retinal ischemia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Veronik Lachance, Sara-Maude Belanger, Celia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, Said Kourrich
Summary: In recent years, research on the Sigma-1R (S1R) protein has shown its importance in maintaining cellular homeostasis through modulation of calcium and lipid exchange, ER-stress response, and other mechanisms. Many of these processes have been linked to neuroprotective roles, and using S1R agonists to improve these mechanisms has shown benefits in treating brain disorders. This review article explores the subcellular localization and biological activity of S1R within specific compartments, and discusses how dysregulation of these pathways contributes to neurodegenerative diseases, highlighting key binding partners and cellular mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Article
Multidisciplinary Sciences
Kohji Yamada, Saya Motohashi, Tsunekazu Oikawa, Naoko Tago, Rei Koizumi, Masaya Ono, Toshiaki Tachibana, Ayano Yoshida, Saishu Yoshida, Masayuki Shimoda, Masahiro Oka, Yoshihiro Yoneda, Kiyotsugu Yoshida
Summary: The study reveals the role of E-Syt1 in mediating cytosolic protein secretion at the ER-PM contact sites in liver cancer cells. SEC22B vesicles tethered to the PM via Q-SNAREs for their secretion, while PKC delta secretion and tumorigenicity were regulated by the interaction with E-Syt1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Anthony V. Morante, Daniel Davidnan Baboolal, Xavier Simon, Elizabeth, Mark Cheng-Ying Pan, Patricio I. Meneses
Summary: The amino acid residues 43-DQILQ-47 of the HPV16 L2 protein play a crucial role in the intracellular trafficking of the virus, particularly in trafficking beyond the endoplasmic reticulum.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang, Yang Sun
Summary: Limonin mitigates DSS-induced chronic colitis by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-kappa B signaling, showing potential as an effective drug for IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Chunhua She, Chao Wu, Weihua Guo, Yongjie Xie, Shouyi Li, Weishuai Liu, Chao Xu, Hui Li, Pei Cao, Yanfang Yang, Xiuchao Wang, Antao Chang, Yukuan Feng, Jihui Hao
Summary: This study identifies RUNX1 as a predictive biomarker for gemcitabine-based chemotherapy response in pancreatic ductal adenocarcinoma (PDAC). Inhibition of RUNX1 may represent an effective strategy for overcoming gemcitabine resistance in PDAC cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Zhenyan He, Linh Lieu, Yanbin Dong, Sadia Afrin, Dominic Chau, Anita Kabahizi, Briana Wallace, Jianhong Cao, Eun-Sang Hwang, Ting Yao, Yiru Huang, Jennifer Okolo, Bo Cheng, Yong Gao, Ling Hu, Kevin W. Williams
Summary: The study showed that PERK deficiency in POMC neurons in male mice may protect against diet-induced obesity, while attenuating the improvements in leptin sensitivity and energy balance induced by celastrol.
Review
Cardiac & Cardiovascular Systems
Frank Lezoualc'h, Lina Badimon, Hana Baker, Monique Bernard, Gabor Czibik, Rudolf A. de Boer, Thomas D'Humieres, Micheline Kergoat, Mark Kowala, Jennifer Rieusset, Gemma Vilahur, Maximin Detrait, Chris Watson, Genevieve A. Derumeaux
Summary: Diabetic cardiomyopathy is a distinct, multifactorial disease that leads to ventricular hypertrophy and abnormal myocardial contractility. Animal models provide opportunities to study its mechanisms, but there are limitations when extrapolating findings to humans.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Gastroenterology & Hepatology
Mariana Milashka-Brihay, Mariana Figueiredo, Miguel Pantaleon Sanchez, Clara Yzet, Sophie Collardeau-Frachon, Jerome Rivory, Mathieu Pioche
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Clinical Neurology
Maerit Jensen, Susanne Sehner, Bastian Cheng, Eckhard Schlemm, Fanny Quandt, Ewgenia Barow, Karl Wegscheider, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Goetz Thomalla, Christian Gerloff
Summary: The study found that intravenous alteplase may have a potential benefit for health-related quality of life (HRQoL) beyond its effect on functional outcome.
Review
Cell Biology
Julien Pestel, Ferdinand Blangero, Assia Eljaafari
Summary: Adipose tissue-derived mesenchymal stem cells (ASCs) exhibit both pro-inflammatory and anti-inflammatory properties depending on the microenvironmental stimuli. In pathological contexts like obesity, ASCs can contribute to the development of obesity-related inflammatory diseases. This review aims to highlight the pathogenic role of ASCs in obesity and describe the mechanisms leading to their dysfunctions, involving factors such as adhesion molecules, TLRs, Th17 cells, Th22 cells, gamma delta T cells, and immune checkpoint overexpression.
Letter
Endocrinology & Metabolism
Charles Thivolet, Etienne Larger, Bertrand Cariou, Eric Renard, Helene Hanaire, Pierre -Yves Benhamou, Bruno Guerci, Emilie Mathiotte, Karim Chikh
DIABETES & METABOLISM
(2023)
Review
Geriatrics & Gerontology
Gabriel Antherieu, Mael Heiblig, Gilles Freyer, Herve Ghesquieres, Claire Falandry
Summary: This study found a high incidence of lymphopenia in adult patients treated with PARPi, especially in older patients, through a retrospective cohort study and scoping review analysis. Future work is needed to improve patient follow-up and discuss prophylactic strategies.
Article
Clinical Neurology
Alexandre Bani-Sadr, Laura Mechtouff, Charles De Bourguignon, Aela Mauffrey, Timothe Boutelier, Tae-Hee Cho, Matteo Cappucci, Roxana Ameli, Marc Hermier, Laurent Derex, Norbert Nighoghossian, Yves Berthezene
Summary: This study aimed to investigate the relationship between baseline blood-brain barrier (BBB) permeability and the kinetics of circulating inflammatory markers in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy. It was found that increased BBB permeability was associated with a larger ischemic core and higher levels of inflammatory markers. In patients with symptom onset <6 hours, increased BBB permeability was also associated with higher MMP-9 levels.
Article
Clinical Neurology
Benedikt Frey, Farhad Shenas, Florent Boutitie, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias B. Endres, Jochen Fiebach, Jens Fiehler, Ivana Galinovic, Ewgenia Barow, Alina Koenigsberg, Eckhard Schlemm, Salvador Pedraza, Robin Lemmens, Vincent W. Thijs, Keith Muir, Norbert Z. Nighoghossian, Claus Simonsen, Christian Gerloff, Goetz Thomalla, WAKE-UP Investigators
Summary: This study aimed to evaluate the impact of white matter hyperintensities burden on the efficacy and safety of thrombolysis in stroke patients with unknown onset. The results showed that WMH burden was associated with worse functional outcome, but did not increase the risk of hemorrhagic transformation. In patients with severe WMH, intravenous thrombolysis was associated with a higher likelihood of excellent outcome without a significant increase in the rate of hemorrhagic transformation.
Correction
Geriatrics & Gerontology
Gaetan Gavazzi, Sabine Drevet, Matthieu Debray, Jean Luc Bosson, Fatah Tidadini, Marc Paccalin, Benoit de Wazieres, Thomas Celarier, Marc Bonnefoy, Virginie Vitrat
Review
Oncology
Zoe Daverio, Aneta Balcerczyk, Gilles J. P. Rautureau, Baptiste Panthu
Summary: Lactic acidosis is a crucial factor in the tumor microenvironment and cancer metabolism. This review aims to explore the mechanisms through which lactic acidosis affects cancer cell metabolism and its contribution to the understanding of tumor metabolism. It also highlights the therapeutic potentials of lactic acidosis.
Article
Cardiac & Cardiovascular Systems
Stefana Enachi, Maxime Schleef, Chahr-Eddine Hadjseyd, Simon Leboube, Charles Fauvel, Lucie Daniel, Antoine Jobbe-Duval, Laurent Sebbag, Sandrine Lemoine, Nathan Mewton
Summary: Chronic kidney disease (CKD) is common in patients with heart failure and reduced ejection fraction (HFrEF), and it is a major factor contributing to adverse outcomes. Despite limited data, studies have shown that HFrEF therapies continue to be effective in improving cardiovascular outcomes in patients with CKD. Most HF drugs cause acute renal hemodynamic changes, but these changes stabilize or even improve after the acute phase, without long-term deterioration of renal function. This paper challenges the misconceptions about the pathophysiology of HF that hinder the implementation of disease-modifying therapy in this context and proposes a strategy for titrating HF drugs in patients with moderate, severe, and end-stage CKD.
CURRENT HEART FAILURE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pauline Delage, Berenice Segrestin, Kevin Seyssel, Stephanie Chanon, Aurelie Vieille-Marchiset, Annie Durand, Angeline Nemeth, Sylviane Metairon, Aline Charpagne, Patrick Descombes, Jorg Hager, Martine Laville, Hubert Vidal, Emmanuelle Meugnier
Summary: The adaptive response to overfeeding involves significant changes in gene expression in adipose tissue. This study investigated whether supplementation with polyphenols could affect these molecular adaptations in lean men. The results showed that polyphenol supplementation modulated gene expression in adipose tissue and potentially protected against adipose tissue expansion during weight gain.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Bani-Sadr, Dylan Pavie, Laura Mechtouff, Matteo Cappucci, Marc Hermier, Roxana Ameli, Laurent Derex, Charles De Bourguignon, Tae-Hee Cho, Omer Eker, Norbert Nighoghossian, Yves Berthezene
Summary: The presence of brush sign is associated with infarct growth after successful thrombectomy, while cerebral collateral status is not.
EUROPEAN RADIOLOGY
(2023)
Article
Critical Care Medicine
Tarek Sharshar, Raphael Porcher, Pierre Asfar, Lamiae Grimaldi, Julien Jabot, Laurent Argaud, Christine Lebert, Pierre-Edouard Bollaert, Marie Line Harlay, Patrick Chillet, Eric Maury, Francois Santoli, Pascal Blanc, Romain Sonneville, Vu Dinh Chuyen, Benjamin Rohaut, Aurelien Mazeraud, Jean-Claude Alvarez, Vincent Navarro, Bernard Clair, Herve Outin
Summary: This multicentre, double-blind, randomised controlled trial in 244 adults with GCSE found that adding VPA as a complementary treatment to the recommended strategy did not increase the proportion of patients discharged from hospital by day 15.