Article
Engineering, Biomedical
Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani, Satyabrata Kar
Summary: Native PLGA nanoparticles show therapeutic potential in the treatment of Alzheimer's disease by suppressing aggregation of beta-amyloid peptides, triggering their disassembly, reducing phosphorylation of tau protein, enhancing neuronal viability, and attenuating memory deficits and A beta levels in animal models of AD.
BIOACTIVE MATERIALS
(2022)
Article
Neurosciences
Carolina Castillo, Gaston Bravo-Arrepol, Aline Wendt, Francisco Saez-Orellana, Camila Millar, Carlos F. Burgos, Javiera Gavilan, Carla Pacheco, Ramon Ahumada-Rudolph, Mariola Napiorkowska, Claudia Perez, Jose Becerra, Jorge Fuentealba, Jaime R. Cabrera-Pardo
Summary: Alzheimer's disease is characterized by cognitive impairment and memory loss due to the accumulation of amyloid-beta peptide. This study found that the compound Eu extracted from conifers has neuroprotective effects against A beta Os-induced synaptic failure.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Takako Niikura
Summary: This review provides an overview of the actions of Humanin in AD-related conditions, highlighting its anti-cell death effects and antagonistic role against various AD-associated pathomechanisms, offering insights into its potential contribution to AD treatments.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biotechnology & Applied Microbiology
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar
Summary: The study found that native PLGA can inhibit the aggregation of A beta peptides and disassemble existing aggregates, protecting neurons from toxicity associated with Alzheimer's disease pathology at temperatures outside the physiological range. These findings support the unique therapeutic potential of PLGA nanoparticles in the treatment of AD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Muhammad Ikram, Myeung Hoon Jo, Kyonghwan Choe, Amjad Khan, Sareer Ahmad, Kamran Saeed, Min Woo Kim, Myeong Ok Kim
Summary: Cycloastragenol demonstrated positive effects against oxidative stress, neurogenic dysfunction, MAP kinase activation, mitochondrial apoptosis, and memory impairment in an A beta-induced mouse model of Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study evaluated the protective effect of genistein against Aβ(1-42)-induced cognitive impairment and elucidated some possible mechanisms involved in its neuroprotective effects in the hippocampus, including attenuation of synaptotoxicity, prevention of Tau hyperphosphorylation, and inactivation of ERK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar
Summary: The study showed that surface-functionalized gold nanoparticles with mimosine can inhibit Aβ aggregation and stabilize it in its monomeric state, reducing neuronal toxicity associated with AD. Additionally, MimoAuNPs can trigger the disassembly of mature Aβ fibers, presenting a potential therapeutic effect on AD-related pathologies.
BIOACTIVE MATERIALS
(2021)
Article
Geriatrics & Gerontology
Xiangwei Song, Yingqi Sun, Zhun Wang, Yingying Su, Yangkun Wang, Xueli Wang
Summary: Exendin-4 attenuates the toxicity of A beta (1-42) in Alzheimer's disease through multiple mechanisms, including reducing its expression and accumulation, and enhancing the activity of superoxide dismutase. It exhibits neuroprotective effects and has potential therapeutic implications for AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Zi-Xuan Tan, Fang Dong, Lin-Yu Wu, Ya-Shuo Feng, Feng Zhang
Summary: Alzheimer's disease is a major burden on global healthcare systems, and effective treatments are needed. Accumulation of neurotoxic beta-amyloid peptide (A beta) is a feature of AD, but medications targeting its reduction have yet to prove effective. Physical exercise has benefits for AD, including reducing A beta deposition to alleviate symptoms.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentina Latina, Anna Atlante, Francesca Malerba, Federico La Regina, Bijorn Omar Balzamino, Alessandra Micera, Annabella Pignataro, Egidio Stigliano, Sebastiano Cavallaro, Pietro Calissano, Giuseppina Amadoro
Summary: In addition to deficits in hippocampal-dependent episodic memory, Alzheimer's Disease (AD) is characterized by sensory impairment in visual cognition due to extensive neuropathology in the retina. A monoclonal antibody called 12A12 has been found to specifically neutralize the harmful tau fragments associated with AD without affecting the normal protein. When administered to a mouse model of AD, 12A12 successfully reduces the accumulation of these tau fragments in the brain and retina, improving the associated symptoms. This study also reveals that 12A12 downregulates the expression of proteins involved in the production of amyloid beta, leading to a decrease in its accumulation in both the hippocampus and retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hongtao Du, Jinzhi Song, Fang Ma, Hongxin Gao, Xinyan Zhao, Renjun Mao, Xiaolong He, Yan Yan
Summary: This study synthesised and characterised a series of novel harmine derivatives as potential ligands for AD treatment. Compounds 13 and 17d showed exceptional neuroprotective effects and potent inhibition against AChE and A beta aggregation. Kinetic studies and molecular modelling confirmed the interaction of compound 13 with both CAS and PAS of AChE.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim
Summary: Caffeic acid has the potential to be used as a therapeutic agent for Alzheimer's disease due to its antioxidant and cognitive-enhancing effects. It reduces oxidative stress, regulates the expression of related proteins, decreases inflammation markers, enhances synaptic markers, and reduces the expression of Alzheimer's disease-related proteins.
Article
Clinical Neurology
Hideomi Hamasaki, Masahiro Shijo, Ayaka Nakamura, Hiroyuki Honda, Yuichi Yamada, Masanao Oda, Tomoyuki Ohara, Toshiharu Ninomiya, Toru Iwaki
Summary: This study investigated the relationship between degenerative changes of the brain and heart, with reference to AD pathologies, ATTR deposition, and cardiac fibrosis in a Japanese population. It found that cardiac ATTR deposition correlated with AD brain pathology among older adults aged 90 or below.
Article
Biochemistry & Molecular Biology
Lorena Saelices, Lisa M. Johnson, Wilson Y. Liang, Michael R. Sawaya, Duilio Cascio, Piotr Ruchala, Julian Whitelegge, Lin Jiang, Roland Riek, David S. Eisenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Lorena Saelices, Rocio Robles-Rengel, Francisco J. Florencio, M. Isabel Muro-Pastor
MOLECULAR MICROBIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
David Pantoja-Uceda, Jose L. Neira, Lorena Saelices, Rocio Robles-Rengel, Francisco J. Florencio, M. Isabel Muro-Pastor, Jorge Santoro
Article
Biochemistry & Molecular Biology
Pascal Krotee, Sarah L. Griner, Michael R. Sawaya, Duilio Cascio, Jose A. Rodriguez, Dan Shi, Stephan Philipp, Kevin Murray, Lorena Saelices, Ji Lee, Paul Seidler, Charles G. Glabe, Lin Jiang, Tamir Gonen, David S. Eisenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Lorena Saelices, Kevin Chung, Ji H. Lee, Whitaker Cohn, Julian P. Whitelegge, Merrill D. Benson, David S. Eisenberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Lorena Saelices, Stuart A. Sievers, Michael R. Sawaya, David S. Eisenberg
Article
Biochemistry & Molecular Biology
Lorena Saelices, Carla V. Galmozzi, Francisco J. Florencio, M. Isabel Muro-Pastor, Jose L. Neira
Article
Microbiology
Carla V. Galmozzi, Lorena Saelices, Francisco J. Florencio, M. Isabel Muro-Pastor
JOURNAL OF BACTERIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Lorena Saelices, Carla V. Galmozzi, Francisco J. Florencio, M. Isabel Muro-Pastor
MOLECULAR MICROBIOLOGY
(2011)
Article
Neurosciences
Lorena Saelices, Malgorzata Pokrzywa, Katarzyna Pawelek, David S. Eisenberg
NEUROBIOLOGY OF DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Lorena Saelices, Binh A. Nguyen, Kevin Chung, Yifei Wang, Alfredo Ortega, Ji H. Lee, Teresa Coelho, Johan Bijzet, Merrill D. Benson, David S. Eisenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Qin Cao, David R. Boyer, Michael R. Sawaya, Romany Abskharon, Lorena Saelices, Binh A. Nguyen, Jiahui Lu, Kevin A. Murray, Fouad Kandeel, David S. Eisenberg
Summary: Human islet amyloid polypeptide (hIAPP) is commonly aggregated in the islet cells of individuals with type II diabetes. New structures of fibrils seeded with patient-derived material show a diverse repertoire of structures, some of which may resemble those appearing in vivo.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marfa del Carmen Fernandez Ramfrez, Shumaila Afrin, Lorena Saelices
Summary: Amyloidoses are fatal diseases characterized by the aggregation of proteins into amyloid fibrils, leading to systemic and/or local deposition. The underlying mechanism of protein aggregation and deposition is not fully understood, making these diseases incurable. However, recent advances in structural biology have allowed the study of protein structures and conformations associated with amyloidosis. This has led to the development of targeted therapeutic strategies focused on specific protein conformations.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lorena Saelices, Loubna Youssar, Iris Holdermann, Salim Al-Babili, Javier Avalos
MOLECULAR GENETICS AND GENOMICS
(2007)