Sepsis: evolving concepts and challenges

A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality

(2018) Rodrigo Serafim et al.   CHEST

Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries

(2018) Kristina E. Rudd et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Accuracy of SOFA, qSOFA, and SIRS scores for mortality in cancer patients admitted to an intensive care unit with suspected infection

(2018) Ramon T. Costa et al.   JOURNAL OF CRITICAL CARE

The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism

(2018) Benjamin A. Fensterheim et al.   JOURNAL OF IMMUNOLOGY

Paradigms of acute kidney injury in the intensive care setting

(2018) John A. Kellum et al.   Nature Reviews Nephrology

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Into the storm : Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life-threatening infections

(2017) James P. O'Gara   ENVIRONMENTAL MICROBIOLOGY

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

qSOFA for Identifying Sepsis Among Patients With Infection

(2017) François Lamontagne et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit

(2017) Eamon P. Raith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department

(2017) Yonathan Freund et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection

(2017) Benjamin A. Fensterheim et al.   JOURNAL OF IMMUNOLOGY

The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study

(2017) Flavia R Machado et al.   LANCET INFECTIOUS DISEASES

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

Expression of genes belonging to the interacting TLR cascades, NADPH-oxidase and mitochondrial oxidative phosphorylation in septic patients

(2017) Laura A. Nucci et al.   PLoS One

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogenesis ofStaphylococcus aureusBloodstream Infections

(2016) Lena Thomer et al.   Annual Review of Pathology-Mechanisms of Disease

CD163 and CD206 expression does not correlate with tolerance and cytokine production in LPS-tolerant human monocytes

(2016) Amanda Barba Alves-Januzzi et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Sepsis and septic shock in low-income and middle-income countries: need for a different paradigm

(2016) Jordi Rello et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

(2016) Manu Shankar-Hari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Sepsis-3 definitions predict ICU mortality in a low–middle-income country

(2016) Bruno Adler Maccagnan Pinheiro Besen et al.   Annals of Intensive Care

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Lactate Measurements in Sepsis-Induced Tissue Hypoperfusion

(2015) Brian Casserly et al.   CRITICAL CARE MEDICINE

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bioenergetics, Mitochondrial Dysfunction, and Oxidative Stress in the Pathophysiology of Septic Encephalopathy

(2013) Fernando A. Bozza et al.   SHOCK

Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury

(2012) Tamás Dolinay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Generation of Nitric Oxide and Reactive Oxygen Species by Neutrophils and Monocytes From Septic Patients and Association With Outcomes

(2012) Sidnéia Sousa Santos et al.   SHOCK

Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During Sepsis

(2012) Reinaldo Salomao et al.   SHOCK

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis

(2010) Jane E. Carré et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human monocytes tolerant to LPS retain the ability to phagocytose bacteria and generate reactive oxygen species

(2010) M.L. Fernandes et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit*

(2010) Andre C. Kalil et al.   CRITICAL CARE MEDICINE

Differential expression of toll-like receptor signaling cascades in LPS-tolerant human peripheral blood mononuclear cells☆

(2010) Marialice Erdelyi Mendes et al.   IMMUNOBIOLOGY

NEUTROPHIL PARALYSIS IN SEPSIS

(2010) José C. Alves-Filho et al.   SHOCK

PATHOPHYSIOLOGICAL ROLES OF PEROXYNITRITE IN CIRCULATORY SHOCK

(2010) Csaba Szabó et al.   SHOCK

Sepsis and Septic Shock: A History

(2009) Duane J. Funk et al.   CRITICAL CARE CLINICS

Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock*

(2009) Mark E. Mikkelsen et al.   CRITICAL CARE MEDICINE

Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients

(2009) Carlos del Fresno et al.   JOURNAL OF IMMUNOLOGY

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Inflammasome mRNA Expression in Human Monocytes during Early Septic Shock

(2008) Ruairi J. Fahy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock*

(2008) Reinaldo Salomao et al.   CRITICAL CARE MEDICINE