GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation

The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure

(2015) Na Xu et al.   JOURNAL OF PATHOLOGY

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

(2014) Melkam A. Kebede et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Actions of Rab3 and Rab27 GTPases on Late Stages of Exocytosis of Insulin

(2014) Victor A. Cazares et al.   TRAFFIC

MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic β-Cell Dysfunction

(2013) Yunxia Zhu et al.   DIABETES

Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection

(2013) Xiu-Xing Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

(2013) Mitsunori Fukuda   TRAFFIC

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes

(2012) Matilde Masini et al.   ACTA DIABETOLOGICA

First Phase Insulin Secretion and Type 2 Diabetes

(2012) K. Cheng et al.   CURRENT MOLECULAR MEDICINE

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

Critical Role of Egr Transcription Factors in Regulating Insulin Biosynthesis, Blood Glucose Homeostasis, and Islet Size

(2012) Isabelle Müller et al.   ENDOCRINOLOGY

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells

(2012) Daleep K. Arora et al.   Islets

Cigarette Smoke–Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling

(2011) Ning Shen et al.   AMERICAN JOURNAL OF PATHOLOGY

GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation

(2011) Ning Shen et al.   AMERICAN JOURNAL OF PATHOLOGY

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice

(2011) Xiao Yu et al.   EMBO JOURNAL

An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism

(2011) Ning Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

(2010) Kazuma Kaneko et al.   Cell Metabolism

Small G Proteins in Islet β-Cell Function

(2010) Anjaneyulu Kowluru   ENDOCRINE REVIEWS

Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells

(2010) Miho Tsuchiya et al.   ENDOCRINOLOGY

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells

(2010) Veronica Dominguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Mevalonate Pathway for Improved Anticancer Therapy

(2009) G. Fritz   CURRENT CANCER DRUG TARGETS

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY