Initiation and perpetuation of NLRP3 inflammasome activation and assembly
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Title
Initiation and perpetuation of NLRP3 inflammasome activation and assembly
Authors
Keywords
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Journal
IMMUNOLOGICAL REVIEWS
Volume 265, Issue 1, Pages 35-52
Publisher
Wiley
Online
2015-04-16
DOI
10.1111/imr.12286
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Note: Only part of the references are listed.- Mechanism of NLRP3 inflammasome activation
- (2014) Fayyaz S. Sutterwala et al. Annals of the New York Academy of Sciences
- Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation
- (2014) Xin Cai et al. CELL
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- Structural mechanisms in NLR inflammasome signaling
- (2014) Bernhard C Lechtenberg et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
- (2014) R. Allam et al. EMBO REPORTS
- Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation
- (2014) Alexander Babich et al. IMMUNOLOGICAL REVIEWS
- Keeping the immune system in check: a role for mitophagy
- (2014) Michael Lazarou IMMUNOLOGY AND CELL BIOLOGY
- The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation
- (2014) Masahiro Okada et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1β Production
- (2014) Kuo-Feng Hua et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
- (2014) Mary A. Rodgers et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome
- (2014) M. Kool et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3
- (2014) H. Li et al. JOURNAL OF IMMUNOLOGY
- Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux
- (2014) Luigi Franchi et al. JOURNAL OF IMMUNOLOGY
- The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA–Induced NLRP3 Inflammasome Activation
- (2014) Leiyun Weng et al. JOURNAL OF IMMUNOLOGY
- Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function
- (2014) M. G. Ghonime et al. JOURNAL OF IMMUNOLOGY
- Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
- (2014) Hao Xu et al. NATURE
- RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
- (2014) Xiaqiong Wang et al. NATURE IMMUNOLOGY
- The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
- (2014) Alberto Baroja-Mazo et al. NATURE IMMUNOLOGY
- The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
- (2014) Bernardo S Franklin et al. NATURE IMMUNOLOGY
- The growing landscape of lysine acetylation links metabolism and cell signalling
- (2014) Chunaram Choudhary et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
- (2014) S. M. Man et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy
- (2014) J. Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity
- (2014) S.-C. Cheng et al. SCIENCE
- Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor
- (2014) S M Son et al. Cell Death & Disease
- Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection
- (2014) Marco A. Ataide et al. PLoS Pathogens
- Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5
- (2014) Stephanie Reikine et al. Frontiers in Immunology
- The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
- (2013) Naeha Subramanian et al. CELL
- AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
- (2013) V Sagulenko et al. CELL DEATH AND DIFFERENTIATION
- Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
- (2013) Y-H Wu et al. CELL DEATH AND DIFFERENTIATION
- Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
- (2013) Kairui Mao et al. CELL RESEARCH
- Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
- (2013) Shankar S. Iyer et al. IMMUNITY
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways
- (2013) Sena Kim et al. Innate Immunity
- The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Physiological Roles
- (2013) Maria Patron et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion
- (2013) Robert van der Burgh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- How Metabolism Generates Signals during Innate Immunity and Inflammation
- (2013) Anne F. McGettrick et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation
- (2013) K. Triantafilou et al. JOURNAL OF CELL SCIENCE
- Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
- (2013) M. E. Heid et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome
- (2013) T. Fernandes-Alnemri et al. JOURNAL OF IMMUNOLOGY
- The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity
- (2013) S. Park et al. JOURNAL OF IMMUNOLOGY
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
- (2013) Hideki Hara et al. NATURE IMMUNOLOGY
- Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
- (2013) Takuma Misawa et al. NATURE IMMUNOLOGY
- Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection
- (2013) Christopher Lupfer et al. NATURE IMMUNOLOGY
- Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid
- (2013) Olivier Jalmar et al. PLoS One
- IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
- (2013) K.-M. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
- (2013) T. Ichinohe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rift Valley fever virus infection induces activation of the NLRP3 inflammasome
- (2013) Megan E. Ermler et al. VIROLOGY
- TRPM2 links oxidative stress to NLRP3 inflammasome activation
- (2013) Zhenyu Zhong et al. Nature Communications
- TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis
- (2013) Young-Jun Park et al. PLoS Pathogens
- Cellular localization of NLRP3 inflammasome
- (2013) Yan Wang et al. Protein & Cell
- Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation
- (2013) Hongbin Wang et al. Protein & Cell
- Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
- (2012) Christine M. Oslowski et al. Cell Metabolism
- IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
- (2012) Alana G. Lerner et al. Cell Metabolism
- Cell Volume Regulation Modulates NLRP3 Inflammasome Activation
- (2012) Vincent Compan et al. IMMUNITY
- The NLRP12 Inflammasome Recognizes Yersinia pestis
- (2012) Gregory I. Vladimer et al. IMMUNITY
- An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
- (2012) Sonal Khare et al. IMMUNITY
- Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
- (2012) Olaf Groß et al. IMMUNITY
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
- (2012) Kenichi Shimada et al. IMMUNITY
- Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction
- (2012) Kate Schroder et al. IMMUNOBIOLOGY
- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
- (2012) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
- (2012) Gloria Lopez-Castejon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome
- (2012) E. Hernandez-Cuellar et al. JOURNAL OF IMMUNOLOGY
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- Phosphorylation of NLRC4 is critical for inflammasome activation
- (2012) Yan Qu et al. NATURE
- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- (2012) Geun-Shik Lee et al. NATURE
- MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
- (2012) Karthik Mallilankaraman et al. NATURE CELL BIOLOGY
- Sensing and reacting to microbes through the inflammasomes
- (2012) Luigi Franchi et al. NATURE IMMUNOLOGY
- Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
- (2012) Chong-Shan Shi et al. NATURE IMMUNOLOGY
- Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
- (2012) Mélanie Bruchard et al. NATURE MEDICINE
- STIM proteins: dynamic calcium signal transducers
- (2012) Jonathan Soboloff et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondria as sensors and regulators of calcium signalling
- (2012) Rosario Rizzuto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Critical role for calcium mobilization in activation of the NLRP3 inflammasome
- (2012) T. Murakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evolutionary Diversity of the Mitochondrial Calcium Uniporter
- (2012) A. G. Bick et al. SCIENCE
- ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation
- (2012) N Riteau et al. Cell Death & Disease
- ER stress activates the NLRP3 inflammasome via an UPR-independent pathway
- (2012) P Menu et al. Cell Death & Disease
- Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
- (2012) Manuela Rossol et al. Nature Communications
- NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
- (2011) Eran Elinav et al. CELL
- Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
- (2011) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
- (2011) Nagaraj Kerur et al. Cell Host & Microbe
- Sensing damage by the NLRP3 inflammasome
- (2011) Jaklien C. Leemans et al. IMMUNOLOGICAL REVIEWS
- Caspase-1-induced pyroptotic cell death
- (2011) Edward A. Miao et al. IMMUNOLOGICAL REVIEWS
- Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly
- (2011) Ju Young Bae et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation
- (2011) James Harris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Making heads or tails of phospholipids in mitochondria
- (2011) Christof Osman et al. JOURNAL OF CELL BIOLOGY
- Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation
- (2011) Y. Qu et al. JOURNAL OF IMMUNOLOGY
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
- (2011) Haitao Wen et al. NATURE IMMUNOLOGY
- Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection
- (2011) Kenichi Shimada et al. PLoS One
- Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis
- (2010) Bryan Heit et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Oxidative stress caused by mitochondrial calcium overload
- (2010) Tsung-I Peng et al. Annals of the New York Academy of Sciences
- Human NLRP3 inflammasome activation is Nox1-4 independent
- (2010) R. van Bruggen et al. BLOOD
- Cutting Edge: NLRC5-Dependent Activation of the Inflammasome
- (2010) B. K. Davis et al. JOURNAL OF IMMUNOLOGY
- NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections
- (2010) H. Kumar et al. JOURNAL OF IMMUNOLOGY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- Circulating mitochondrial DAMPs cause inflammatory responses to injury
- (2010) Qin Zhang et al. NATURE
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
- (2010) Kiichi Nakahira et al. NATURE IMMUNOLOGY
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mechanistic Issues of the Interaction of the Hairpin-Forming Domain of tBid with Mitochondrial Cardiolipin
- (2010) François Gonzalvez et al. PLoS One
- Mitochondrial calcium and the permeability transition in cell death
- (2009) John J. Lemasters et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria
- (2009) Maurizio Sorice et al. FEBS LETTERS
- CA-074Me Protection against Anthrax Lethal Toxin
- (2009) Z. L. Newman et al. INFECTION AND IMMUNITY
- Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome
- (2009) Mohamed Lamkanfi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis
- (2009) Gang Li et al. JOURNAL OF CELL BIOLOGY
- Inflammasomes: too big to miss
- (2009) Andrea Stutz et al. JOURNAL OF CLINICAL INVESTIGATION
- Cutting Edge: TNF- Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
- (2009) L. Franchi et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain
- (2009) N. B. Bryan et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome
- (2009) S. Joly et al. JOURNAL OF IMMUNOLOGY
- Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner
- (2009) Jessica Chu et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
- (2009) Olaf Gross et al. NATURE
- The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
- (2009) Beom Seok Park et al. NATURE
- Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
- (2009) Hendrik Poeck et al. NATURE IMMUNOLOGY
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal
- (2009) Catherine Dostert et al. PLoS One
- Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation
- (2008) Veerle Vanderheyden et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
- (2008) X. Liu et al. BLOOD
- The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
- (2008) Luigi Franchi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The NLR Gene Family: A Standard Nomenclature
- (2008) Jenny P.-Y. Ting et al. IMMUNITY
- Cardiolipin provides an essential activating platform for caspase-8 on mitochondria
- (2008) Francois Gonzalvez et al. JOURNAL OF CELL BIOLOGY
- Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals
- (2008) Yi-Ping Rong et al. MOLECULAR CELL
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
- Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
- (2008) Stephanie C. Eisenbarth et al. NATURE
- Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
- (2008) Tatsuya Saitoh et al. NATURE
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- The Nalp3 inflammasome is essential for the development of silicosis
- (2008) Suzanne L. Cassel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1 and IL-18 secretion in an autocrine way
- (2008) A. Piccini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
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