C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex

Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses

(2021) Jungjoo Park et al.   EMBO JOURNAL

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

(2021) Xin Ding et al.   Nature Communications

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

(2020) Tao Li et al.   EMBO JOURNAL

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

(2020) Qifei Cong et al.   NATURE NEUROSCIENCE

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

(2020) Nicole D. Schartz et al.   Journal of Neuroinflammation

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

(2020) Melis Yilmaz et al.   NATURE NEUROSCIENCE

Neuron-Glia Signaling in Synapse Elimination

(2019) Daniel K. Wilton et al.   Annual Review of Neuroscience

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

(2019) Georgia Gunner et al.   NATURE NEUROSCIENCE

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

(2019) Sebastian Werneburg et al.   IMMUNITY

Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q

(2019) Christina A. Welsh et al.   JOURNAL OF NEUROSCIENCE

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

(2019) Sabrina Reinehr et al.   Frontiers in Pharmacology

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene

(2018) Breeanne M. Soteros et al.   PLoS One

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Microglia and the Brain: Complementary Partners in Development and Disease

(2018) Timothy R. Hammond et al.   Annual Review of Cell and Developmental Biology

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

The microglial fractalkine receptor is not required for activity-dependent plasticity in the mouse visual system

(2017) Rebecca L. Lowery et al.   GLIA

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1

(2017) Rachel W. Schecter et al.   JOURNAL OF NEUROSCIENCE

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

(2017) Jeffrey M. Harder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors

(2016) C M Sellgren et al.   MOLECULAR PSYCHIATRY

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Sculpting Neural Circuits by Axon and Dendrite Pruning

(2015) Martin M. Riccomagno et al.   Annual Review of Cell and Developmental Biology

Specification of synaptic connectivity by cell surface interactions

(2015) Joris de Wit et al.   NATURE REVIEWS NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Activity dependent mechanisms of visual map formation - From retinal waves to molecular regulators

(2014) Ahlem Assali et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue

(2014) Milosz P. Kawa et al.   Journal of Immunology Research

Remodeling of dendrites and spines in theC1qknockout model of genetic epilepsy

(2013) Yunyong Ma et al.   EPILEPSIA

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Comparing development of synaptic proteins in rat visual, somatosensory, and frontal cortex

(2013) Joshua G. A. Pinto et al.   Frontiers in Neural Circuits

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

(2011) M. E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Genetics and Cell Biology of Building Specific Synaptic Connectivity

(2010) Kang Shen et al.   Annual Review of Neuroscience

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Mechanisms Underlying Development of Visual Maps and Receptive Fields

(2008) Andrew D. Huberman et al.   Annual Review of Neuroscience