Specification of synaptic connectivity by cell surface interactions

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms

(2015) Marc V. Fuccillo et al.   NEURON

Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

(2015) Wataru Kakegawa et al.   NEURON

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

The classic cadherins in synaptic specificity

(2015) Raunak Basu et al.   Cell Adhesion & Migration

The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells

(2015) Séverine M. Sigoillot et al.   Cell Reports

Quantitative isoform-profiling of highly diversified recognition molecules

(2015) Dietmar Schreiner et al.   eLife

Cellular and Molecular Mechanisms of Synaptic Specificity

(2014) Shaul Yogev et al.   Annual Review of Cell and Developmental Biology

Single-Cell Identity Generated by Combinatorial Homophilic Interactions between α, β, and γ Protocadherins

(2014) Chan Aye Thu et al.   CELL

Molecular Profiling of Neurons Based on Connectivity

(2014) Mats I. Ekstrand et al.   CELL

Type II Cadherins Guide Assembly of a Direction-Selective Retinal Circuit

(2014) Xin Duan et al.   CELL

Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1

(2014) Takatoshi Iijima et al.   JOURNAL OF CELL BIOLOGY

Netrin-G/NGL Complexes Encode Functional Synaptic Diversification

(2014) H. Matsukawa et al.   JOURNAL OF NEUROSCIENCE

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis

(2014) Jeffrey N Savas et al.   Nature Protocols

Regional Diversity and Developmental Dynamics of the AMPA-Receptor Proteome in the Mammalian Brain

(2014) Jochen Schwenk et al.   NEURON

Neuronal Ig/Caspr Recognition Promotes the Formation of Axoaxonic Synapses in Mouse Spinal Cord

(2014) Soha Ashrafi et al.   NEURON

Dendrite Self-Avoidance Requires Cell-Autonomous Slit/Robo Signaling in Cerebellar Purkinje Cells

(2014) Daniel A. Gibson et al.   NEURON

Targeted Combinatorial Alternative Splicing Generates Brain Region-Specific Repertoires of Neurexins

(2014) Dietmar Schreiner et al.   NEURON

Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing

(2014) Barbara Treutlein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of neural circuit formation by leucine-rich repeat proteins

(2014) Joris de Wit et al.   TRENDS IN NEUROSCIENCES

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures

(2014) Naoko H. Tomioka et al.   Nature Communications

Synaptic Laminae in the Visual System: Molecular Mechanisms Forming Layers of Perception

(2013) Herwig Baier   Annual Review of Cell and Developmental Biology

The Molecular Basis of Self-Avoidance

(2013) S. Lawrence Zipursky et al.   Annual Review of Neuroscience

An Extracellular Interactome of Immunoglobulin and LRR Proteins Reveals Receptor-Ligand Networks

(2013) Engin Özkan et al.   CELL

Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking

(2013) Jason Aoto et al.   CELL

The cell biology of synaptic specificity during development

(2013) Ryan Christensen et al.   CURRENT OPINION IN NEUROBIOLOGY

Clustered protocadherins

(2013) W. V. Chen et al.   DEVELOPMENT

In situ sequencing for RNA analysis in preserved tissue and cells

(2013) Rongqin Ke et al.   NATURE METHODS

The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development

(2013) Katherine L. Pettem et al.   NEURON

The Neuron Identity Problem: Form Meets Function

(2013) Gord Fishell et al.   NEURON

Unbiased Discovery of Glypican as a Receptor for LRRTM4 in Regulating Excitatory Synapse Development

(2013) Joris de Wit et al.   NEURON

An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells

(2013) Tabrez J. Siddiqui et al.   NEURON

On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms

(2013) L. O. Sun et al.   SCIENCE

Teneurin-3 Specifies Morphological and Functional Connectivity of Retinal Ganglion Cells in the Vertebrate Visual System

(2013) Paride Antinucci et al.   Cell Reports

Cadherins and neuropsychiatric disorders

(2012) Christoph Redies et al.   BRAIN RESEARCH

Assembly of synaptic laminae by axon guidance molecules

(2012) Estuardo Robles et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses

(2012) Dilja D Krueger et al.   CURRENT OPINION IN NEUROBIOLOGY

High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex

(2012) Antony A. Boucard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala

(2012) Nicole Hertel et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular and Functional Interaction between Protocadherin- C5 and GABAA Receptors

(2012) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Expanding the Ig Superfamily Code for Laminar Specificity in Retina: Expression and Role of Contactins

(2012) M. Yamagata et al.   JOURNAL OF NEUROSCIENCE

Teneurins instruct synaptic partner matching in an olfactory map

(2012) Weizhe Hong et al.   NATURE

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons

(2012) Jeremy N. Kay et al.   NATURE

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system

(2012) Julie L. Lefebvre et al.   NATURE

Getting neural circuits into shape with semaphorins

(2012) R. Jeroen Pasterkamp   NATURE REVIEWS NEUROSCIENCE

NGL-2 Regulates Input-Specific Synapse Development in CA1 Pyramidal Neurons

(2012) Laura A. DeNardo et al.   NEURON

γ-Protocadherins Control Cortical Dendrite Arborization by Regulating the Activity of a FAK/PKC/MARCKS Signaling Pathway

(2012) Andrew M. Garrett et al.   NEURON

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

(2012) Matthew L. O'Sullivan et al.   NEURON

Sonic Hedgehog Expression in Corticofugal Projection Neurons Directs Cortical Microcircuit Formation

(2012) Corey C. Harwell et al.   NEURON

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Cadherins in Brain Morphogenesis and Wiring

(2012) Shinji Hirano et al.   PHYSIOLOGICAL REVIEWS

Elfn1 Regulates Target-Specific Release Probability at CA1-Interneuron Synapses

(2012) E. L. Sylwestrak et al.   SCIENCE

Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems

(2012) Keizo Hirano et al.   Frontiers in Molecular Neuroscience

Role of Leucine-Rich Repeat Proteins in the Development and Function of Neural Circuits

(2011) Joris de Wit et al.   Annual Review of Cell and Developmental Biology

SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1

(2011) Takatoshi Iijima et al.   CELL

Retinal Ganglion Cells with Distinct Directional Preferences Differ in Molecular Identity, Structure, and Central Projections

(2011) J. N. Kay et al.   JOURNAL OF NEUROSCIENCE

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina

(2011) Ryota L. Matsuoka et al.   NATURE

Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate

(2011) Jeremy N Kay et al.   NATURE NEUROSCIENCE

Temporally matched subpopulations of selectively interconnected principal neurons in the hippocampus

(2011) Yuichi Deguchi et al.   NATURE NEUROSCIENCE

Cadherin-9 Regulates Synapse-Specific Differentiation in the Developing Hippocampus

(2011) Megan E. Williams et al.   NEURON

The role of neurexins in schizophrenia and autistic spectrum disorder

(2011) A.C. Reichelt et al.   NEUROPHARMACOLOGY

Non-clustered protocadherin

(2011) Soo-Young Kim et al.   Cell Adhesion & Migration

Development of Axon-Target Specificity of Ponto-Cerebellar Afferents

(2011) Anna Kalinovsky et al.   PLOS BIOLOGY

High-throughput identification of transient extracellular protein interactions

(2010) Gavin J. Wright et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chemoaffinity Revisited: Dscams, Protocadherins, and Neural Circuit Assembly

(2010) S. Lawrence Zipursky et al.   CELL

Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

(2010) Takeshi Uemura et al.   CELL

Synaptic organizing complexes

(2010) Tabrez J Siddiqui et al.   CURRENT OPINION IN NEUROBIOLOGY

Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo

(2010) George W. Huntley et al.   HIPPOCAMPUS

Synaptic and nonsynaptic localization of protocadherin-γC5 in the rat brain

(2010) Yanfang Li et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers

(2010) H. Tawarayama et al.   JOURNAL OF NEUROSCIENCE

LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development

(2010) T. J. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Construction of a Large Extracellular Protein Interaction Network and Its Resolution by Spatiotemporal Expression Profiling

(2010) Stephen Martin et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular Mechanisms of Synaptic Specificity in Developing Neural Circuits

(2010) Megan E. Williams et al.   NEURON

SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning

(2010) Elissa M. Robbins et al.   NEURON

Neurexins Physically and Functionally Interact with GABAA Receptors

(2010) Chen Zhang et al.   NEURON

Design Principles of Insect and Vertebrate Visual Systems

(2010) Joshua R. Sanes et al.   NEURON

Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level

(2010) K. Krishna-K et al.   NEUROSCIENCE

Combinatorial homophilic interaction between  -protocadherin multimers greatly expands the molecular diversity of cell adhesion

(2010) D. Schreiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many Paths to Synaptic Specificity

(2009) Joshua R. Sanes et al.   Annual Review of Cell and Developmental Biology

Proteomics Analysis Reveals Overlapping Functions of Clustered Protocadherins

(2009) Meng-Hsuan Han et al.   MOLECULAR & CELLULAR PROTEOMICS

Specificity of sensory–motor connections encoded by Sema3e–Plxnd1 recognition

(2009) Eline Pecho-Vrieseling et al.   NATURE

LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

(2009) Joris de Wit et al.   NEURON

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

(2009) Jaewon Ko et al.   NEURON

A cell surface interaction network of neural leucine-rich repeat receptors

(2009) Christian Söllner et al.   GENOME BIOLOGY

Dscam-Mediated Cell Recognition Regulates Neural Circuit Formation

(2008) Daisuke Hattori et al.   Annual Review of Cell and Developmental Biology

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

Layer-Specific Expression of Multiple Cadherins in the Developing Visual Cortex (V1) of the Ferret

(2008) Krishna-K et al.   CEREBRAL CORTEX

Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans

(2008) Milica A Margeta et al.   CURRENT OPINION IN NEUROBIOLOGY

Large-scale screening for novel low-affinity extracellular protein interactions

(2008) K. M. Bushell et al.   GENOME RESEARCH

A cadherin-based code for the divisions of the mouse basal ganglia

(2008) Nicole Hertel et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina

(2008) Masahito Yamagata et al.   NATURE

A Screen of Cell-Surface Molecules Identifies Leucine-Rich Repeat Proteins as Key Mediators of Synaptic Target Selection

(2008) Mitsuhiko Kurusu et al.   NEURON

Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway

(2007) Iddil H. Bekirov et al.   HIPPOCAMPUS