Review
Developmental Biology
Megumi Andoh, Ryuta Koyama
Summary: Synapses are fundamental structures that transmit information between neurons in neural circuits. Proper synaptic connections shape the basis of brain functions and animal behavior. Microglia play important roles in regulating synaptic function, and the underlying molecular mechanisms have been thoroughly studied.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Neurosciences
Lihuan Lan, Hongxuan Wang, Xiaoni Zhang, Qingyu Shen, Xiangpen Li, Lei He, Xiaoming Rong, Jialing Peng, Jingjing Mo, Ying Peng
Summary: Long-term alcohol intake leads to synapse loss and cognitive impairment. Microglia-mediated synaptic elimination may play a key role in this mechanism.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Senthilkumar Deivasigamani, Mariya T. Miteva, Silvia Natale, Daniel Gutierrez-Barragan, Bernadette Basilico, Silvia Di Angelantonio, Laetitia Weinhard, Dmitry Molotkov, Sukrita Deb, Constantin Pape, Giulia Bolasco, Alberto Galbusera, Hiroki Asari, Alessandro Gozzi, Davide Ragozzino, Cornelius T. Gross
Summary: This study found that mice lacking Complement receptor 3 showed a deficit in the perinatal elimination of neurons in the developing cortex, resulting in increased cortical thickness and enhanced functional connectivity in these regions in adulthood. These findings demonstrate the importance of complement in promoting neuronal elimination in the developing cortex.
Review
Endocrinology & Metabolism
Tongtong Xu, Chang Liu, Shiyu Deng, Lin Gan, Zhijun Zhang, Guo-Yuan Yang, Hengli Tian, Yaohui Tang
Summary: Myelination is a crucial process in the central nervous system, and microglia and astrocytes play important roles in this process. They are involved in development, clearance of degenerated myelin debris, and regulation of remyelination. This review summarizes their roles in the developmental and diseased brain, as well as their interaction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Anesthesiology
Qian Zhai, Ying Zhang, Mao Ye, Shan Zhu, Jianyu Sun, Yue Wang, Bin Deng, Daqing Ma, Qiang Wang
Summary: This study found that sleep deprivation leads to cognitive decline, associated with synapse elimination and complement pathway activation, and dexmedetomidine can protect against these effects. These findings provide a basis for further research on the role of dexmedetomidine in preventing cognitive deficits caused by sleep deprivation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Multidisciplinary Sciences
Johnny E. Elguero, Guangmei Liu, Katherine Tiemeyer, Shruthi Bandyadka, Heena Gandevia, Lauren Duro, Zhenhao Yan, Kimberly Mccall
Summary: This study found that Drosophila mutants lacking the phagocytic receptor Draper have phagocytic defects leading to neurodegenerative diseases. The study also discovered that phagocytic defects cause neurodegeneration through increased immune signaling.
Article
Immunology
Xiaoxiao Hao, Zhaofei Li, Wei Li, Jannet Katz, Suzanne M. Michalek, Scott R. Barnum, Lucas Pozzo-Miller, Takashi Saito, Takaomi C. Saido, Qin Wang, Erik D. Roberson, Ping Zhang
Summary: Periodontitis may worsen the development and severity of Alzheimer's disease (AD), but the mechanism by which it does so remains unclear. Using a mouse model, this study found that oral infection worsened cognitive impairment and accelerated amyloid beta accumulation in AD mice. The study also revealed that periodontal infection complicates the neuroinflammatory status established by AD and amplifies microglial activation, neuroinflammation, and synaptic tagging through brain overactivation of complement C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Akash Shah, Uday Kishore, Abhishek Shastri
Summary: This article discusses how the complement system plays a role in the functioning of the central nervous system, while also contributing to chronic neuroinflammation leading to neurodegenerative disorders like Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pablo J. Lituma, Evan Woo, Bruce F. O'Hara, Pablo E. Castillo, Nicholas E. S. Sibinga, Sayan Nandi
Summary: Growing evidence suggests that Iba1 protein plays a crucial role in regulating synaptic pruning, transmission, and plasticity. Aif1(-/-) mice exhibited deficits in excitatory synapse number, synaptic drive, and behavior, indicating the importance of Iba1 in microglial activity and neuroglial developmental processes. These findings highlight the significant contribution of Iba1 in excitatory synaptic growth and its impact on behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Ying Chen, John Man Tak Chu, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Summary: The complement system plays a crucial role in the central nervous system beyond immunity, impacting neurodevelopment and neurodegenerative diseases. Proper activation of the complement system is essential for maintaining normal brain function, but overactivation or dysregulation may lead to synaptic dysfunction and excessive pro-inflammatory responses. Targeting complement factors shows therapeutic potential for neurodegenerative conditions.
Article
Neurosciences
Xiaoxiang Tan, Jiajia Wang, Juan Yao, Jing Yuan, Yuchen Dai, Menghan Sun, Tianhao Zhang, Jiaojiao Yang, Wenlan Cai, Lili Qiu, Jie Sun
Summary: This study found that elderly patients after surgery are prone to cognitive decline, which may be related to the activation of microglia and the increase of complement protein expression in the hippocampus induced by surgery. The study established a model of cognitive decline in aged mice and showed the involvement of microglia and the complement system in cognitive dysfunction. Suppressing microglia activation and the association between microglia and complement can alleviate cognitive dysfunction.
NEUROSCIENCE LETTERS
(2023)
Article
Medicine, Research & Experimental
Chenchen Li, Bo Liu, Jingyi Xu, Bin Jing, Lijie Guo, Liyong Wang, Milin Wang, Haochen Zhang, Qianqian He, Xin Yu, Yan Zhang, Zhi-Qing David Xu, Yutao Yang
Summary: The study found that PHL can effectively prevent depressive symptoms induced by chronic mild stress, improve the structural and functional abnormalities in the cortex, and display neuroprotective effects by inhibiting the NF-KB-C3 axis and microglia-mediated synaptic engulfment.
Article
Medicine, General & Internal
Feng Xu, Linlin Han, Yafeng Wang, Daling Deng, Yuanyuan Ding, Shuai Zhao, Qingtong Zhang, Lulin Ma, Xiangdong Chen
Summary: Prolonged anesthesia triggers neuroinflammation and complement-mediated microglial synaptic engulfment, leading to the occurrence of postoperative neurocognitive disorders.
Review
Medicine, Research & Experimental
Breeanne M. Soteros, Gek Ming Sia
Summary: Synapse elimination, a critical step in neural circuit maturation during brain development, is regulated by the complement-microglia system through diverse molecular signals. Dysregulation of this system may underlie specific circuit defects in developmental brain disorders, implicating it as a potential therapeutic target.
WIRES MECHANISMS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Gabriela L. Carrillo, Jianmin Su, Mikel L. Cawley, Derek Wei, Simran K. Gill, Ira J. Blader, Michael A. Fox
Summary: The parasitic infection of Toxoplasma gondii can alter neural circuits by selectively removing inhibitory synapses on excitatory pyramidal neurons, leading to central nervous system infection and increased risk for neurological and neuropsychiatric disorders.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Oncology
Huanjun Chen, Qifei Cong, Zhenyun Du, Wenfeng Liao, Lei Zhang, Yanli Yao, Kan Ding
Article
Chemistry, Applied
Wucheng Wang, Huanjun Chen, Lei Zhang, Yi Qin, Qifei Cong, Peipei Wang, Kan Ding
CARBOHYDRATE POLYMERS
(2016)
Article
Biochemistry & Molecular Biology
L. Zhang, P. Wang, Y. Qin, Q. Cong, C. Shao, Z. Du, X. Ni, P. Li, K. Ding
Article
Multidisciplinary Sciences
Breeanne M. Soteros, Qifei Cong, Christian R. Palmer, Gek-Ming Sia
Article
Neurosciences
Qifei Cong, Breeanne M. Soteros, Mackenna Wollet, Jun Hee Kim, Gek-Ming Sia
NATURE NEUROSCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Yang Li, Qiao Yin, Qi Li, An-ran Huo, Ting-ting Shen, Jia-qian Cao, Chun-feng Liu, Tong Liu, Wei-feng Luo, Qi-fei Cong
Summary: In this study, the mechanisms underlying the anti-depressive effect of botulinum neurotoxin A (BoNT/A) in a Parkinson's disease (PD) mouse model were investigated. The results demonstrated that BoNT/A treatment significantly ameliorated depressive-like behaviors and neurochemical changes in the brain. Furthermore, BoNT/A suppressed inflammatory responses mediated by microglia. These findings suggest that BoNT/A may be effective in improving depression by reversing synaptic loss and alleviating inflammation.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Medicine, Research & Experimental
Breeanne M. Soteros, Gek Ming Sia
Summary: Synapse elimination, a critical step in neural circuit maturation during brain development, is regulated by the complement-microglia system through diverse molecular signals. Dysregulation of this system may underlie specific circuit defects in developmental brain disorders, implicating it as a potential therapeutic target.
WIRES MECHANISMS OF DISEASE
(2022)