Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

Evolutionary conflicts and adverse effects of antiviral factors

(2021) Daniel Sauter et al.   eLife

IFIH1 Contributes to M1 Macrophage Polarization in ARDS

(2021) Shi Zhang et al.   Frontiers in Immunology

Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators

(2021) Jeyun Jo et al.   BIOORGANIC CHEMISTRY

Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

(2021) Yifan Que et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Molecular docking, binding mode analysis, molecular dynamics, and prediction of ADMET/toxicity properties of selective potential antiviral agents against SARS-CoV-2 main protease: an effort toward drug repurposing to combat COVID-19

(2021) Himanshu Rai et al.   MOLECULAR DIVERSITY

Suppressing Cdk5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways

(2021) Ratchaneekorn Reudhabibadh et al.   MOLECULES

Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19

(2021) Charles Ochieng’ Olwal et al.   Frontiers in Immunology

Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?

(2020) Ahmed S. Abouhashem et al.   ANTIOXIDANTS & REDOX SIGNALING

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

(2020) Tommy Tsan-Yuk Lam et al.   NATURE

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

(2020) Frank L van de Veerdonk et al.   eLife

Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection

(2020) Heinz Fischer et al.   Frontiers in Immunology

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

A lesson from a saboteur: High‐MW kininogen impact in coronavirus‐induced disease 2019

(2020) Chiara Colarusso et al.   BRITISH JOURNAL OF PHARMACOLOGY

Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers

(2020) Irena Voinsky et al.   DRUG DEVELOPMENT RESEARCH

New-Onset Diabetes in Covid-19

(2020) Francesco Rubino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

(2020) Hong-Long Ji et al.   PHYSIOLOGICAL REVIEWS

COVID‐19 and human spermatozoa—Potential risks for infertility and sexual transmission?

(2020) Robert John Aitken   Andrology

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation

(2020) Satoshi Wada et al.   Frontiers in Cell and Developmental Biology

Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19

(2020) Joe M. McCord et al.   Antioxidants

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic

(2020) Anil Kumar Rana et al.   CYTOKINE & GROWTH FACTOR REVIEWS

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

(2020) Manvendra Singh et al.   Cell Reports

Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

(2020) Shou Ping Guan et al.   AGEING RESEARCH REVIEWS

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factor

(2020) Zahra Eslamifar et al.   Thrombosis Journal

Influenza infection, SARS, MERS and COVID-19: Cytokine storm – The common denominator and the lessons to be learned

(2020) Varvara A. Ryabkova et al.   CLINICAL IMMUNOLOGY

The role of NO in COVID-19 and potential therapeutic strategies

(2020) Wanyi Fang et al.   FREE RADICAL BIOLOGY AND MEDICINE

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Carnosic Acid Improves Outcome after Repetitive Mild Traumatic Brain Injury

(2019) Mark E. Maynard et al.   JOURNAL OF NEUROTRAUMA

Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates

(2019) Clayton M. Carey et al.   Cell Host & Microbe

MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats

(2019) Abiodun T Kukoyi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies

(2019) Ying Song et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Repression of Nrf2/ARE regulated antioxidant genes and dysregulation of the cellular redox environment by the HIV Transactivator of Transcription

(2019) Ari Simenauer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasminflammation—An Emerging Pathway to Bradykinin Production

(2019) Coen Maas   Frontiers in Immunology

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program

(2019) Emanuel Wyler et al.   Nature Communications

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

(2018) Jonathan A. Kropski et al.   JOURNAL OF CLINICAL INVESTIGATION

Carnosic Acid as a Promising Agent in Protecting Mitochondria of Brain Cells

(2018) Marcos Roberto de Oliveira   MOLECULAR NEUROBIOLOGY

Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells

(2018) Lulu Zhou et al.   Redox Biology

The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells

(2018) Qian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro

(2018) Zheng Jing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease

(2018) Sarah K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

(2018) Chaker El Kalamouni et al.   Viruses-Basel

Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway

(2017) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging

(2017) Mariam El Assar et al.   Journal of the American Medical Directors Association

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms

(2016) Dushani L. Palliyaguru et al.   FREE RADICAL BIOLOGY AND MEDICINE

The status of Nrf2-based therapeutics: current perspectives and future prospects

(2016) IrinaG Gazaryan et al.   Neural Regeneration Research

Reduced Expression of the MDA5 GeneIFIH1Prevents Autoimmune Diabetes

(2015) Pamela J. Lincez et al.   DIABETES

Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a

(2015) Eric J. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

(2015) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation

(2015) Richard M. LoPachin et al.   FREE RADICAL RESEARCH

Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid

(2015) Dongxian Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

(2014) Masahide Funabiki et al.   IMMUNITY

Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking

(2014) A Sato et al.   LEUKEMIA

Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity

(2014) Otis C. Attucks et al.   PLoS One

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

(2014) Ian M. Copple et al.   TOXICOLOGICAL SCIENCES

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

(2014) David Olagnier et al.   PLoS Pathogens

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioavailability of the major bioactive diterpenoids in a rosemary extract: Metabolic profile in the intestine, liver, plasma, and brain of Zucker rats

(2013) María Romo Vaquero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Therapeutic Effect of Lecithinized Superoxide Dismutase on Pulmonary Emphysema

(2011) K.-I. Tanaka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Fibrinogen as a key regulator of inflammation in disease

(2011) Dimitrios Davalos et al.   Seminars in Immunopathology

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice

(2010) R. Pawlinski et al.   BLOOD

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

(2010) James W. Kaspar et al.   FASEB JOURNAL

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

NOS3 PROTECTS AGAINST SYSTEMIC INFLAMMATION AND MYOCARDIAL DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS

(2010) Masahiko Bougaki et al.   SHOCK

Tissue Factor in Coagulation

(2009) Saulius Butenas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls

(2009) Chun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY