Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking
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Title
Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking
Authors
Keywords
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Journal
LEUKEMIA
Volume 29, Issue 1, Pages 145-156
Publisher
Springer Nature
Online
2014-05-05
DOI
10.1038/leu.2014.151
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- Early thrombin generation and impaired fibrinolysis after SCT associate with acute GVHD
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- Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
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- An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
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- Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
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