Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19
出版年份 2021 全文链接
标题
Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19
作者
关键词
Nrf2, PB125, Carnosic acid, SARS-CoV-2, Coronavirus, COVID-19, Cytokines, Interferon, Endothelium
出版物
FREE RADICAL BIOLOGY AND MEDICINE
Volume 175, Issue -, Pages 56-64
出版商
Elsevier BV
发表日期
2021-05-28
DOI
10.1016/j.freeradbiomed.2021.05.033
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
- (2021) Xin Yin et al. Cell Reports
- Evolutionary conflicts and adverse effects of antiviral factors
- (2021) Daniel Sauter et al. eLife
- IFIH1 Contributes to M1 Macrophage Polarization in ARDS
- (2021) Shi Zhang et al. Frontiers in Immunology
- Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators
- (2021) Jeyun Jo et al. BIOORGANIC CHEMISTRY
- Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality
- (2021) Yifan Que et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Molecular docking, binding mode analysis, molecular dynamics, and prediction of ADMET/toxicity properties of selective potential antiviral agents against SARS-CoV-2 main protease: an effort toward drug repurposing to combat COVID-19
- (2021) Himanshu Rai et al. MOLECULAR DIVERSITY
- Suppressing Cdk5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways
- (2021) Ratchaneekorn Reudhabibadh et al. MOLECULES
- Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19
- (2021) Charles Ochieng’ Olwal et al. Frontiers in Immunology
- Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?
- (2020) Ahmed S. Abouhashem et al. ANTIOXIDANTS & REDOX SIGNALING
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins
- (2020) Tommy Tsan-Yuk Lam et al. NATURE
- Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
- (2020) Frank L van de Veerdonk et al. eLife
- Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection
- (2020) Heinz Fischer et al. Frontiers in Immunology
- TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
- (2020) Ruochen Zang et al. Science Immunology
- A lesson from a saboteur: High‐MW kininogen impact in coronavirus‐induced disease 2019
- (2020) Chiara Colarusso et al. BRITISH JOURNAL OF PHARMACOLOGY
- Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers
- (2020) Irena Voinsky et al. DRUG DEVELOPMENT RESEARCH
- New-Onset Diabetes in Covid-19
- (2020) Francesco Rubino et al. NEW ENGLAND JOURNAL OF MEDICINE
- Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility
- (2020) Hong-Long Ji et al. PHYSIOLOGICAL REVIEWS
- COVID‐19 and human spermatozoa—Potential risks for infertility and sexual transmission?
- (2020) Robert John Aitken Andrology
- Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
- (2020) Jeong Seok Lee et al. Science Immunology
- Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation
- (2020) Satoshi Wada et al. Frontiers in Cell and Developmental Biology
- Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
- (2020) Joe M. McCord et al. Antioxidants
- Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
- (2020) Jin Wei et al. CELL
- Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
- (2020) Anil Kumar Rana et al. CYTOKINE & GROWTH FACTOR REVIEWS
- SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
- (2020) David Olagnier et al. Nature Communications
- A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors
- (2020) Manvendra Singh et al. Cell Reports
- Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?
- (2020) Shou Ping Guan et al. AGEING RESEARCH REVIEWS
- Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
- (2020) Rajendra Karki et al. CELL
- Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factor
- (2020) Zahra Eslamifar et al. Thrombosis Journal
- Influenza infection, SARS, MERS and COVID-19: Cytokine storm – The common denominator and the lessons to be learned
- (2020) Varvara A. Ryabkova et al. CLINICAL IMMUNOLOGY
- The role of NO in COVID-19 and potential therapeutic strategies
- (2020) Wanyi Fang et al. FREE RADICAL BIOLOGY AND MEDICINE
- TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection
- (2019) Naoko Iwata-Yoshikawa et al. JOURNAL OF VIROLOGY
- Carnosic Acid Improves Outcome after Repetitive Mild Traumatic Brain Injury
- (2019) Mark E. Maynard et al. JOURNAL OF NEUROTRAUMA
- Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates
- (2019) Clayton M. Carey et al. Cell Host & Microbe
- MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats
- (2019) Abiodun T Kukoyi et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner
- (2019) Dong-Dong Huang et al. EXPERIMENTAL GERONTOLOGY
- Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies
- (2019) Ying Song et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Repression of Nrf2/ARE regulated antioxidant genes and dysregulation of the cellular redox environment by the HIV Transactivator of Transcription
- (2019) Ari Simenauer et al. FREE RADICAL BIOLOGY AND MEDICINE
- Plasminflammation—An Emerging Pathway to Bradykinin Production
- (2019) Coen Maas Frontiers in Immunology
- Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
- (2019) Emanuel Wyler et al. Nature Communications
- RIG-I and Other RNA Sensors in Antiviral Immunity
- (2018) Kwan T. Chow et al. Annual Review of Immunology
- Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
- (2018) Jonathan A. Kropski et al. JOURNAL OF CLINICAL INVESTIGATION
- Carnosic Acid as a Promising Agent in Protecting Mitochondria of Brain Cells
- (2018) Marcos Roberto de Oliveira MOLECULAR NEUROBIOLOGY
- Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells
- (2018) Lulu Zhou et al. Redox Biology
- The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells
- (2018) Qian Zuo et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro
- (2018) Zheng Jing et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease
- (2018) Sarah K. Baker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus
- (2018) Chaker El Kalamouni et al. Viruses-Basel
- Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway
- (2017) Narayana Komaravelli et al. FREE RADICAL BIOLOGY AND MEDICINE
- Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging
- (2017) Mariam El Assar et al. Journal of the American Medical Directors Association
- Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
- (2016) Rudragouda Channappanavar et al. Cell Host & Microbe
- Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms
- (2016) Dushani L. Palliyaguru et al. FREE RADICAL BIOLOGY AND MEDICINE
- The status of Nrf2-based therapeutics: current perspectives and future prospects
- (2016) IrinaG Gazaryan et al. Neural Regeneration Research
- Reduced Expression of the MDA5 GeneIFIH1Prevents Autoimmune Diabetes
- (2015) Pamela J. Lincez et al. DIABETES
- Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a
- (2015) Eric J. Smith et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative stress response and Nrf2 signaling in aging
- (2015) Hongqiao Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Molecular basis of the Keap1–Nrf2 system
- (2015) Takafumi Suzuki et al. FREE RADICAL BIOLOGY AND MEDICINE
- Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2
- (2015) Narayana Komaravelli et al. FREE RADICAL BIOLOGY AND MEDICINE
- Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation
- (2015) Richard M. LoPachin et al. FREE RADICAL RESEARCH
- Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid
- (2015) Dongxian Zhang et al. JOURNAL OF NEUROCHEMISTRY
- Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5
- (2014) Masahide Funabiki et al. IMMUNITY
- Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking
- (2014) A Sato et al. LEUKEMIA
- Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity
- (2014) Otis C. Attucks et al. PLoS One
- Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids
- (2014) Ian M. Copple et al. TOXICOLOGICAL SCIENCES
- Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells
- (2014) David Olagnier et al. PLoS Pathogens
- Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
- (2013) Takumi Satoh et al. FREE RADICAL BIOLOGY AND MEDICINE
- Bioavailability of the major bioactive diterpenoids in a rosemary extract: Metabolic profile in the intestine, liver, plasma, and brain of Zucker rats
- (2013) María Romo Vaquero et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Therapeutic Effect of Lecithinized Superoxide Dismutase on Pulmonary Emphysema
- (2011) K.-I. Tanaka et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
- (2011) Brooks M. Hybertson et al. MOLECULAR ASPECTS OF MEDICINE
- Fibrinogen as a key regulator of inflammation in disease
- (2011) Dimitrios Davalos et al. Seminars in Immunopathology
- Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice
- (2010) R. Pawlinski et al. BLOOD
- Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression
- (2010) James W. Kaspar et al. FASEB JOURNAL
- Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes
- (2010) Kate Downes et al. PLoS One
- NOS3 PROTECTS AGAINST SYSTEMIC INFLAMMATION AND MYOCARDIAL DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS
- (2010) Masahiko Bougaki et al. SHOCK
- Tissue Factor in Coagulation
- (2009) Saulius Butenas et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls
- (2009) Chun Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro
- (2009) Yiu-Wing Kam et al. PLoS One
- The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
- (2008) M. Kobayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1
- (2007) Takumi Satoh et al. JOURNAL OF NEUROCHEMISTRY
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